<p>Hormonal Function Responses to Moderate Aerobic Exercise in Older Adults with Depression</p>

Abstract

Background: Poor daily life physical activities among older people were related to depressive mood especially memory loss. In addition to that, the change in physical ability is significantly associated with the score of depression among older age. Objective: The present study aimed to evaluate the effects of a supervised aerobic training program with moderate intensity for 12 weeks on mood profiles and hormonal levels of the hypothalamus-pituitary-adrenal axis (HPA axis) of older adults. Methods: A total of 80 individuals of both gender (90 males, 110 females) of ages ranged between 65 and 95 years were recruited for this study. Based upon the profile of mood states (POMS) analysis, the participants were classified into two groups: control group (n=30) and depressive group (n=50). Leisure-time physical activity (LTPA), adrenal hormones such as ACTH, corticosterone (CORT), cortisol, DHEA/S, and cortisol:DHEA/S ratio were measured at baseline and post-intervention of moderate aerobic exercise for 12 weeks. Results: Older adults with higher depressive scores showed a remarkable change in the level of adrenal hormones compared to control. There was a significant increase in the level of ACTH, CORT, cortisol, and cortisol:DHEA/S ratio, and decrease in DHEA/S. Compared to females, males showed an improvement in depressive mood score along with an increase in LPTA, DHEA/S and decrease in ACTH, CORT, cortisol, cortisol:DHEA/S ratio following 12 weeks of supervised aerobic training, respectively. Conclusion: The findings of this study showed that 12 weeks of supervised exercise interventions are promising non-drug therapeutic strategies in improving depression among older adults. The potential performance in a psychological state occurs physiologically via optimizing the levels of the hormones of the HPA axis.

Mechanisms linking physical activity with psychiatric symptoms across lifespan: A systematic review

“…The copyright holder for this preprint this version posted July 15, 2022. ; https://doi.org/10.1101/2022.07.13.22277479 doi: medRxiv preprint [36]. Three intervention studies did not have a control group; all participants had to participate in the same training program [34,43,47]. Session duration ranged from 30 minutes [36] to 60 minutes [43,44,47].…”

Effects of Lifestyle Factors on Cognition in Minority Population of Older Adults: A Review

“…In addition to cognition, PA is related to several mood parameters ( 71 – 74 ). Among healthy older adults, 10–12 weeks of physical activity was shown to reduce depression and improve vigor ( 71 , 72 ).…”

“…In addition to cognition, PA is related to several mood parameters ( 71 – 74 ). Among healthy older adults, 10–12 weeks of physical activity was shown to reduce depression and improve vigor ( 71 , 72 ). The effectiveness of physical activity to reduce depression has even been shown among community dwelling older adults, who are known to have high rates of depression ( 73 , 74 ).…”

“…The effectiveness of physical activity to reduce depression has even been shown among community dwelling older adults, who are known to have high rates of depression ( 73 , 74 ). Furthermore, moderate intensity exercise training over 12 weeks significantly lowered depression, anger, fatigue, and tension in older adults with pre-intervention depression ( 71 ). This is relevant, as depression itself is a potential contributor to cognitive decline and dementia ( 12 ).…”

Using Online Information Support to Decrease Stress, Anxiety, and Depression

“…In lay usage, depression means occasional sadness and gloom [18]. It refers to feelings that can be enough to have negative influences on human mood and change social daily life [19]. Depression causes feelings of sadness and leads to life problems.…”