&lt;p&gt;Identification of Novel Biomarkers for Predicting Kidney Injury Due to Drugs Using “Omic” Strategies&lt;/p&gt;

Awdishu, Linda; Atilano-Roque, Amandla; Tuey, Stacey; Joy, Melanie S.

doi:10.2147/pgpm.s239471

Cited by 9 publications

(6 citation statements)

References 89 publications

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“…The analyses of traditionally used biomarkers, such as serum creatinine and blood urea nitrogen, do not provide high sensitivity and specificity or appropriate timeliness for identifying drug-induced kidney damage. The development of novel biomarkers is currently in progress, and metabolomics holds promise for the early and sensitive detection of kidney damage [ 28 ]. However, this strategy needs to be confirmed by further studies.…”

Section: Discussionmentioning

confidence: 99%

Surufatinib-induced renal thrombotic microangiopathy: first case report and review of literature

et al. 2023

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Angiogenesis inhibitors such as tyrosine kinase inhibitors (TKIs) are common therapeutics currently used to treat oncologic disease. Surufatinib is a novel, small-molecule multiple receptor TKI approved by the National Medical Products Administration (NMPA) for the treatment of progressive, advanced, and well-differentiated pancreatic and extrapancreatic neuroendocrine tumours (NETs). Thrombotic microangiopathy (TMA) is a well-documented complication of TKIs targeting the VEGF-A/VEGFR2 signalling pathway. Here, we describe a 43-year-old female patient with biopsy-proven TMA and nephrotic syndrome due to surufatinib treatment for adenoid cystic carcinoma. Histological lesions included glomerular endothelial swelling, widening of subendothelial spaces, mesangiolysis, and double contour, which caused nephrotic proteinuria. Effective management was achieved by drug withdrawal and oral anti-hypertensive regents. The management of surufatinib-related nephrotoxicity without compromising its anticancer effects is challenging. Hypertension and proteinuria must be closely monitored during drug use to reduce or stop the dose in a timely manner before severe nephrotoxicity occurs.

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Section: Discussionmentioning

confidence: 99%

Surufatinib-induced renal thrombotic microangiopathy: first case report and review of literature

et al. 2023

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“… 153–155 Furthermore, multi-omics for predicting drug-induced kidney injury will likely become a central topic. 156 Increased interest from the industry to save drug development costs will require computational strategies for drug repurposing, a cost-effective way of developing new targets for existing drugs. 157 Fortunately, the kidney disease field can utilize approaches from other fields, such as oncology.…”

Section: Ev Multi-omics To Understand Mechanisms Of Therapeutic Activ...mentioning

confidence: 99%

Systems Approaches to Cell Culture-Derived Extracellular Vesicles for Acute Kidney Injury Therapy: Prospects and Challenges

Lundy,

Szomolay,

Liao

2024

Function

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Acute kidney injury (AKI) is a heterogeneous syndrome, comprising diverse aetiologies of kidney insults which result in high mortality and morbidity if not well-managed. Although great efforts have been made to investigate underlying pathogenic mechanisms of AKI, there are limited therapeutic strategies available. Extracellular vesicles (EV) are membrane-bound vesicles secreted by various cell types which can serve as cell-free therapy through transfer of bioactive molecules. In this review, we first overview the AKI syndrome and EV biology, with a particular focus on the technical aspects and therapeutic application of cell culture-derived EVs. Secondly, we illustrate how multi-omic approaches to EV miRNA, protein and genomic cargo analysis can yield new insights into their mechanisms of action and address unresolved questions in the field. We then summarise major experimental evidence regarding the therapeutic potential of EVs in AKI, which we subdivide into stem cell and non-stem cell-derived EVs. Finally, we highlight the challenges and opportunities related to clinical translation of animal studies into human patients.

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“…Drug-induced precision nephrotoxicity is characterized by alterations in the expression of mRNAs and miRNAs in human primary renal cells or patientderived renal cells (i.e., USCs), which can influence the development and progression of the disease, as well as play protective roles [100]. The regulation of the transcriptome is modulated through a variety of pathways, including transcriptional initiation, RNA processing and post-translational modification, which can affect the expression of genes involved in the pathological or recovery processes of drug induced kidney disease (DIKD).…”

Section: Exploring the Mechanisms Of Drug-induced Precision Nephrotox...mentioning

confidence: 99%

Precision nephrotoxicity testing using 3D in vitro models

Yu,

Zhu,

Bosholm

et al. 2023

Cell Biosci

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Nephrotoxicity is a significant concern during the development of new drugs or when assessing the safety of chemicals in consumer products. Traditional methods for testing nephrotoxicity involve animal models or 2D in vitro cell cultures, the latter of which lack the complexity and functionality of the human kidney. 3D in vitro models are created by culturing human primary kidney cells derived from urine in a 3D microenvironment that mimics the fluid shear stresses of the kidney. Thus, 3D in vitro models provide more accurate and reliable predictions of human nephrotoxicity compared to existing 2D models. In this review, we focus on precision nephrotoxicity testing using 3D in vitro models with human autologous urine-derived kidney cells as a promising approach for evaluating drug safety.

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<p>Identification of Novel Biomarkers for Predicting Kidney Injury Due to Drugs Using “Omic” Strategies</p>

Cited by 9 publications

References 89 publications

Surufatinib-induced renal thrombotic microangiopathy: first case report and review of literature

Surufatinib-induced renal thrombotic microangiopathy: first case report and review of literature

Systems Approaches to Cell Culture-Derived Extracellular Vesicles for Acute Kidney Injury Therapy: Prospects and Challenges

Precision nephrotoxicity testing using 3D in vitro models

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