<p>In-situ Electrospinning for Intestinal Hemostasis</p>

Abstract

Introduction: During routine surgery, rapid hemostasis, especially the rapid hemostasis of internal organs, is very important. The emergence of in-situ electrospinning technology has fundamentally solved this problem. It exhibits a high speed of hemostasis, and no bleeding occurs after surgery. Thus, it is of great significance. The use of sutures in some human organs, such as the intestines and bladder, is inadequate because fluid leakage occurs due to the presence of pinholes. Methods: Three types of large intestine wounds with an opening of about 1 cm were investigated. They were untreated, treated by needle and threaded, and treated by hand-held electrospinning, respectively. Results: The results show that hand-held electrospinning technique effectively prevented the exudation of fluids in the intestinal tract. The average diameter of the nanofibrous membrane was about 0.5 μm with hole of several micrometers. It can be elongated 90% without breakage. The hand-held electrospinning device could be used with nitrile gloves, preventing the risk of infection caused by exposed hands. Discussion: This work can provide a reference for future animal experiments and clinical experiments. However, safety should be investigated before application.

Hybrid Bioactive Hydrogel Promotes Liver Regeneration through the Activation of Kupffer Cells and ECM Remodeling After Partial Hepatectomy

“…The advancements in hemostatic techniques have played a pivotal role in enabling surgeons to perform increasingly intricate procedures using minimally invasive approaches. [41,42] The dopamine grafted to hyaluronic acid gives hydrogels strong wet tissue adhesion. The hydrogel adheres to the tissue and becomes a strong physical wall against blood leakage.…”

Electrospun Nanofibers Revisited: An Update on the Emerging Applications in Nanomedicine

“…In addition, the resulting matrices are bulky with possible inadequate stability restricting their ease of transportation and storage, accounting for a higher risk of degradation. Portable ES devices, on the other hand, are easily assembled using completely available off-shelf materials while producing highly efficient fibers for point of need application [ 188 ], mainly implemented in wound dressings with skin regenerating qualities [ 189 , 190 , 191 ] and rapid hemostasis [ 192 ] either in minimally invasive surgeries [ 193 ] or outdoor settings [ 194 ].…”

“…Zhou et al, 2020 proposed that it is was possible to use a portable ES device for in situ simultaneous application of PCL ES fibers in rapid intestinal hemostasis, as shown in Figure 11 . The generated fiber matrices had strong adsorptive forces to wound exudates and were able to resist hydrostatic pressure; additionally, they had an overall good sealing effect [ 192 ].…”

“…Furthermore, the interest in using in situ fiber in mildly invasive surgeries over the conventional methods is increasing. However, this technology is in the early phase of its applications in clinical studies [ 192 ]. The problem with the approach is that the human body’s conductive nature could precipitate short circuits and creepage.…”

Nanofabrication of Janus Fibers through Side-by-Side Electrospinning - A Mini Review

“…An active ingredient and a polymer are co-dissolved into a solvent or a solvent mixture to form an electrospinnable working fluid. The working fluid is transferred into a solid nanofiber mat with the active ingredient highly homogeneously distributed all over the polymeric matrix [26][27][28][29]. Then, the active ingredient is able to take advantage of the huge surface area of electrospun nanofiber mat for exerting its functional performances such as catalysis, drug release, absorbing, separation, and so on.…”