&lt;p&gt;In vitro and in vivo Study of a Novel Liposome-Mediated Dual Drug Delivery for Synergistic Lung Cancer Therapy via Oral Administration&lt;/p&gt;

Zhou, Qi; Fu, Zhiqiang

doi:10.2147/ott.s276837

Cited by 8 publications

(2 citation statements)

References 27 publications

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“…At the molecular level, the effect was achieved by downregulating EGFR and blocking the interaction of Sp1 and HADC1 [ 102 ]. More recently, the increased efficacy of this treatment in this cancer has been reported through the use of a liposome-based co-delivery system [ 107 ].…”

Section: The Combination Of Curcumin and Chemotherapy Drugs In Cancer...mentioning

confidence: 99%

An Overview of the Enhanced Effects of Curcumin and Chemotherapeutic Agents in Combined Cancer Treatments

Cacciola,

Cuciniello,

Petillo

et al. 2023

IJMS

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Due to the progressive ageing of the human population, the number of cancer cases is increasing. For this reason, there is an urgent need for new treatments that can prolong the lives of cancer patients or ensure them a good quality of life. Although significant progress has been made in the treatment of cancer in recent years and the survival rate of patients is increasing, limitations in the use of conventional therapies include the frequent occurrence of side effects and the development of resistance to chemotherapeutic agents. These limitations are prompting researchers to investigate whether combining natural agents with conventional drugs could have a positive therapeutic effect in cancer treatment. Several natural bioactive compounds, especially polyphenols, have been shown to be effective against cancer progression and do not exert toxic effects on healthy tissues. Many studies have investigated the possibility of combining polyphenols with conventional drugs as a novel anticancer strategy. Indeed, this combination often has synergistic benefits that increase drug efficacy and reduce adverse side effects. In this review, we provide an overview of the studies describing the synergistic effects of curcumin, a polyphenol that has been shown to have extensive cytotoxic functions against cancer cells, including combined treatment. In particular, we have described the results of recent preclinical and clinical studies exploring the pleiotropic effects of curcumin in combination with standard drugs and the potential to consider it as a promising new tool for cancer therapy.

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Section: The Combination Of Curcumin and Chemotherapy Drugs In Cancer...mentioning

confidence: 99%

An Overview of the Enhanced Effects of Curcumin and Chemotherapeutic Agents in Combined Cancer Treatments

Cacciola,

Cuciniello,

Petillo

et al. 2023

IJMS

View full text Add to dashboard Cite

show abstract

“…Co-delivery is the delivery of two substances with different functions together to achieve synergistic effects. Zhou et al reported the co-delivery of gefitinib (GFT) and curcumin loaded in liposomes with PEGylated phospholipids and soybean phosphatidylcholine (PC) [57]. GFT is an inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase activity in diverse tumors.…”

Section: Liposomes and Phytosomesmentioning

confidence: 99%

Advanced Delivery System of Polyphenols for Effective Cancer Prevention and Therapy

Kim

Min

et al. 2023

Antioxidants

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Polyphenols from plants such as fruits and vegetables are phytochemicals with physiological and pharmacological activity as potential drugs to modulate oxidative stress and inflammation associated with cardiovascular disease, chronic disease, and cancer. However, due to the limited water solubility and bioavailability of many natural compounds, their pharmacological applications have been limited. Researchers have made progress in the development of nano- and micro-carriers that can address these issues and facilitate effective drug delivery. The currently developed drug delivery systems maximize the fundamental effects in various aspects such as absorption rate, stability, cellular absorption, and bioactivity of polyphenols. This review focuses on the antioxidant and anti-inflammatory effects of polyphenols enhanced by the introduction of drug delivery systems, and ultimately discusses the inhibition of cancer cell proliferation, growth, and angiogenesis.

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Liposome-based curcumin delivery systems as cancer therapeutics

Mostajeran,

Alavizadeh,

Gheybi

et al. 2024

Curcumin-Based Nanomedicines as Cancer Therapeutics

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<p>In vitro and in vivo Study of a Novel Liposome-Mediated Dual Drug Delivery for Synergistic Lung Cancer Therapy via Oral Administration</p>

Cited by 8 publications

References 27 publications

An Overview of the Enhanced Effects of Curcumin and Chemotherapeutic Agents in Combined Cancer Treatments

An Overview of the Enhanced Effects of Curcumin and Chemotherapeutic Agents in Combined Cancer Treatments

Advanced Delivery System of Polyphenols for Effective Cancer Prevention and Therapy

Liposome-based curcumin delivery systems as cancer therapeutics

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