&lt;p&gt;Incidence and Risk Factors for Suicide Attempts in Patients Diagnosed with Major Depressive Disorder&lt;/p&gt;

Peter, Angélica Gonçalves; Molina, Mariane Lopez; Cardoso, Taiane de Azevedo; Mondin, Thaíse Campos; Silva, Ricardo Azevedo da; Jansen, Karen; Barros, M M D; Santos, Érico Nobre dos; Aguiar, Kyara Rodrigues de; Souza, Luciano Dias de Mattos

doi:10.2147/prbm.s274769

Cited by 5 publications

(1 citation statement)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Risk for STBs is also elevated after exposure to early-life stress such as trauma, abuse, neglect, or bullying experiences in childhood or adolescence (Barzilay et al, 2021;Chen et al, 2021;Duprey, Handley, Manly, Cicchetti, & Toth, 2021;Gonçalves Peter et al, 2020;Lebowitz, Blumberg, & Silverman, 2019;Roh et al, 2015;Saint Onge, Cepeda, Lee King, & Valdez, 2013;Sewall et al, 2020). Stress experiences during development are thought to shape brain development in multiple ways, including through alterations in synaptic pruning of neuronal networks (Johnson, Fields, & Bluett, 2020).…”

Section: Introductionmentioning

confidence: 99%

Elevated cognitive rumination and adverse life events are associated with lower cortical surface area and suicidal ideation in adolescents with major depressive disorder

Dauvermann¹,

Schmaal²,

Čolić³

et al. 2022

Preprint

View full text Add to dashboard Cite

Introduction. Suicide is the second most common cause of death among young people. Structural brain alterations, psychological functioning, and early-life stress (ELS) contribute to suicidal thoughts and behaviors (STBs).Methods. Here, we employed structural equation modeling (SEM) to examine the unique and combined relationships of these risk factors with STBs in a sample of young people with major depressive disorder (MDD) from the Magnetic Resonance-Improving Mood with Psychoanalytic and Cognitive Therapies (MR-IMPACT) study (N = 67, mean age = 15.90). Results. When covaried for depressive symptoms, we found that ruminative functioning was independently associated with lower surface area of brain regions known to be involved in both STBs and rumination, including prefrontal, parietal, and temporal regions. However, when the risk factors for STBs were examined together, only rumination was associated with suicidal ideation.Limitations. We emphasize that these findings from this secondary analysis are hypothesis-forming and preliminary in nature given the small sample size for SEM analyses.Conclusion. Our findings suggest that both ELS and higher ruminations may be linked to lower surface area of brain regions to specifically increase suicidal ideation in young people with MDD.

show abstract

Section: Introductionmentioning

confidence: 99%

Elevated cognitive rumination and adverse life events are associated with lower cortical surface area and suicidal ideation in adolescents with major depressive disorder

Dauvermann¹,

Schmaal²,

Čolić³

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

Elevated cognitive rumination and adverse life events are associated with lower cortical surface area and suicidal ideation in adolescents with major depressive disorder

Dauvermann

Schmaal

Čolić

et al. 2023

Journal of Affective Disorders

View full text Add to dashboard Cite

Genome-wide methylome-based molecular pathologies associated with depression and suicide

Dwivedi,

Roy,

Korla

2024

Neuropsychopharmacol.

View full text Add to dashboard Cite

Major depressive disorder (MDD) is a debilitating disorder. Suicide attempts are 5-times higher in MDD patients than in the general population. Interestingly, not all MDD patients develop suicidal thoughts or complete suicide. Thus, it is important to study the risk factors that can distinguish suicidality among MDD patients. The present study examined if DNA methylation changes can distinguish suicidal behavior among depressed subjects. Genome-wide DNA methylation was examined in the dorsolateral prefrontal cortex of depressed suicide (MDD+S; n = 15), depressed non-suicide (MDD−S; n = 17), and nonpsychiatric control (C; n = 16) subjects using 850 K Infinium Methylation EPIC BeadChip. The significantly differentially methylated genes were used to determine the functional enrichment of genes for ontological clustering and pathway analysis. Based on the number of CpG content and their relative distribution from specific landmark regions of genes, 32,958 methylation sites were identified across 12,574 genes in C vs. MDD+/−S subjects, 30,852 methylation sites across 12,019 genes in C vs. MDD−S, 41,648 methylation sites across 13,941 genes in C vs. MDD+S, and 49,848 methylation sites across 15,015 genes in MDD−S vs. MDD+S groups. A comparison of methylation sites showed 33,129 unique methylation sites and 5451 genes in the MDD−S group compared to the MDD+S group. Functional analysis suggested oxytocin, GABA, VGFA, TNFA, and mTOR pathways associated with suicide in the MDD group. Altogether, our data show a distinct pattern of DNA methylation, the genomic distribution of differentially methylated sites, gene enrichment, and pathways in MDD suicide compared to non-suicide MDD subjects.

show abstract

<p>Incidence and Risk Factors for Suicide Attempts in Patients Diagnosed with Major Depressive Disorder</p>

Cited by 5 publications

References 39 publications

Elevated cognitive rumination and adverse life events are associated with lower cortical surface area and suicidal ideation in adolescents with major depressive disorder

Elevated cognitive rumination and adverse life events are associated with lower cortical surface area and suicidal ideation in adolescents with major depressive disorder

Elevated cognitive rumination and adverse life events are associated with lower cortical surface area and suicidal ideation in adolescents with major depressive disorder

Genome-wide methylome-based molecular pathologies associated with depression and suicide

Contact Info

Product

Resources

About