&lt;p&gt;Incidence, clinical features, and risk factors of fluoroquinolone-induced acute liver injury: a case-control study&lt;/p&gt;

Yang, Hongyi; Guo, Dai-Hong; Jia, Wangping; Zhu, Man; Xu, Yuanjie; Wang, Xiaoyu

doi:10.2147/tcrm.s195802

Cited by 13 publications

(17 citation statements)

References 37 publications

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“…Liver dysfunction is a rare adverse effect of fluoroquinolone, but serious. Although the mechanism of fluoroquinolone‐induced liver dysfunction is still unknown, many reports indicated that this adverse effect may be because of the immunoallergic reaction 50 . Also, DM is one of the diseases that is associated with electrolyte abnormalities 51 .…”

Section: Discussionmentioning

confidence: 99%

Effect of ciprofloxacin vs levofloxacin on QTc‐interval and dysglycemia in diabetic and non‐diabetic patients

Saad

Elberry

Matar

et al. 2021

Int. J. Clin. Pract.

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Fluoroquinolones represent an important class of antibacterial drugs and they are used worldwide because they have many advantages as a broad spectrum of activity, oral and intravenous formulations, high potency, high serum levels, large distribution volume, and good bioavailability. 1,2 However, fluoroquinolones may cause several side effects as tendon rupture, central nervous toxicity, cardiovascular toxicity, gastrointestinal toxicity, phototoxicity, disrupted glucose metabolism, skin disorders, and hypersensitivity. 3 The US Food and Drug Administration (FDA) suggested that the risk and benefits ratio of fluoroquinolones should be taken into consideration. 4 Cardiac side effects as the corrected QT interval (QTc) prolongation and torsade de pointes (Tdp) were the cause that some agents of fluoroquinolones were withdrawn from the market. However, still in clinical practice, there are agents of fluoroquinolones associated with these side effects as ciprofloxacin and levofloxacin. 5 Besides, several reports proved that fluoroquinolones may cause dysglycemic events in diabetic and non-diabetic patients. 6 Hyperglycemia events are more common with fluoroquinolones than with other classes of antibiotics. 7 In addition, FDA confirmed the current warning regarding the high risk of developing hypoglycemic events with fluoroquinolones may cause a decrease in blood sugar especially in diabetic patients. 8 When fluoroquinolones are used in diabetic patients, should monitor the blood glucose level continuously. 9 Besides, Diabetes mellitus (DM) is a major risk factor for cardiovascular diseases as QTc prolongation. 10,11 The QT interval represents both the depolarisation and repolarisation phase of the action potential of the

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Section: Discussionmentioning

confidence: 99%

Effect of ciprofloxacin vs levofloxacin on QTc‐interval and dysglycemia in diabetic and non‐diabetic patients

Saad

Elberry

Matar

et al. 2021

Int. J. Clin. Pract.

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“…The system is an adverse event warning system independently developed by our hospital that can automatically retrieve and alert the staff about suspected patients according to condition settings to improve work efficiency. The stability and accuracy of the system have been verified many times 6,8,9 . The researchers then screened the suspected patients.…”

Section: Methodsmentioning

confidence: 99%

Incidence, characteristics and risk factors for drug‐induced liver injury in hospitalized patients: A matched case‐control study

Kong

Guo

Liu

et al. 2021

Brit J Clinical Pharma

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The diagnosis of drug-induced liver injury (DILI) is relatively complex and involves a wide variety of drugs. The purpose of this study was to use algorithms to quickly screen DILI patients, determine its incidence and identify risk factors. Methods:The Adverse Drug Events Active Surveillance and Assessment System-2 was used to extract the data of patients hospitalized in 2019 according to the set standards and the Roussel Uclaf Causality Assessment Method was used to evaluate patients who met the standards. A retrospective case-control study was conducted according to suspected drugs, length of hospital stay and height-and weightmatched controls, and logistic regression was used to identify risk factors.Results: Among the 156 570 hospitalized patients, 480 patients (499 cases) with DILI were confirmed and the incidence of DILI was 0.32%. Anti-infective agents, antineoplastic agents and nonsteroidal anti-inflammatory drugs were the major categories of drugs causing DILI, and the highest incidence of DILI was due to voriconazole. The latency period and hospital stay of patients with cholestasis were both relatively long.Patients with hyperlipidaemia (adjusted odds ratio [AOR] 1.884), cardiovascular disease (AOR 1.465), pre-existing liver disease (AOR 1.827) and surgical history (AOR 1.312) were at higher risk for DILI. Conclusions:The incidence of DILI in hospitalized patients was uncommon (0.32%) and its pathogenic drugs were widely distributed. The incidence of DILI for many drugs has been seriously underestimated. It is recommended to focus on patients with hyperlipidaemia, cardiovascular disease, pre-existing liver disease and surgical history.

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“…The ADE-ASAS is based on trigger technology and text recognition technology, which can be connected to the HIS to extract patient information. Intelligent active surveillance of a single drug in multiple ADR modules can be accomplished [ 14 , 15 ]. The accuracy of this system has been evaluated in multiple studies, with a positive predictive value reaching 69.4% [ 15 , 16 ].…”

Section: Methodsmentioning

confidence: 99%

Clinical Characteristics of Hospitalized Patients with Drug-Induced Acute Kidney Injury and Associated Risk Factors: A Case-Control Study

Guo

Yan

et al. 2020

BioMed Research International

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Background. Drug-induced acute kidney injury (D-AKI) is increasingly common and can extend the hospital length of stay and increase mortality. This study is aimed at analyzing the clinical characteristics of hospitalized patients with D-AKI and the associated risk factors in a multidrug environment. Methods. A retrospective study among hospitalized patients was conducted in July 2019 based on the Adverse Drug Events Active Surveillance and Assessment System-2 developed by the authors. Four controls were matched with each case according to the matching criteria. The risk factors for D-AKI were identified by binary multivariate logistic regression. Results. A total of 23,073 patients were hospitalized in July 2019, 21,131 of whom satisfied the inclusion criteria. The independent risk factors for D-AKI consisted of alcohol abuse (odds ratio (OR), 2.05; 95% confidence interval (CI), 1.04-4.07), nonsteroidal anti-inflammatory drug (NSAID) use (OR, 2.39; 95% CI, 1.25-4.58), diuretic use (OR, 2.64; 95% CI, 1.42-4.92), prior anemia (OR, 4.10; 95% CI, 1.94-8.67), and prior chronic kidney disease (OR, 2.33; 95% CI, 1.07-5.08). Conclusions. The occurrence of D-AKI in hospitalized patients had significant associations with alcohol abuse, combination therapy with NSAIDs or diuretics, and prior anemia or chronic kidney disease. Clinicians should meticulously follow patients with the above characteristics.

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<p>Incidence, clinical features, and risk factors of fluoroquinolone-induced acute liver injury: a case-control study</p>

Cited by 13 publications

References 37 publications

Effect of ciprofloxacin vs levofloxacin on QTc‐interval and dysglycemia in diabetic and non‐diabetic patients

Effect of ciprofloxacin vs levofloxacin on QTc‐interval and dysglycemia in diabetic and non‐diabetic patients

Incidence, characteristics and risk factors for drug‐induced liver injury in hospitalized patients: A matched case‐control study

Clinical Characteristics of Hospitalized Patients with Drug-Induced Acute Kidney Injury and Associated Risk Factors: A Case-Control Study

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