&lt;p&gt;Integrin α5/ITGA5 Promotes The Proliferation, Migration, Invasion And Progression Of Oral Squamous Carcinoma By Epithelial–Mesenchymal Transition&lt;/p&gt;

Deng, Yanfei; Wan, Quan; Yan, Wangxiang

doi:10.2147/cmar.s223201

Cited by 45 publications

(36 citation statements)

References 25 publications

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“…11 Altered expression of ITGA5 has been demonstrated in certain cancers, including colorectal, breast, and oral cancers. [12][13][14] In this study, we confirmed that miR-27b was significantly downregulated while ITGA5 was significantly upregulated in TSCC. Then, we showed that miR-27b inhibited the proliferation, migration, and invasion of TSCC cells in vitro and suppressed tumor growth in vivo.…”

Section: Introductionsupporting

confidence: 74%

<p>miR-27b Suppresses Tongue Squamous Cell Carcinoma Epithelial–Mesenchymal Transition by Targeting ITGA5</p>

Li¹,

Wu²,

Liu³

et al. 2020

OTT

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Section: Introductionsupporting

confidence: 74%

<p>miR-27b Suppresses Tongue Squamous Cell Carcinoma Epithelial–Mesenchymal Transition by Targeting ITGA5</p>

Li¹,

Wu²,

Liu³

et al. 2020

OTT

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“…These genes have also been relevant in other tumor types. For example, ITGA5, an integrin that promotes tumor invasion 70 , has been correlated with lower survival of lung cancer patients 71 , and it also functions as a receptor for FN1 72 , 73 , which was also upregulated in our coculture. IL4R induces a prometastatic phenotype in epithelial tumors.…”

Section: Discussionmentioning

confidence: 79%

Adipose-derived mesenchymal stem cells promote the malignant phenotype of cervical cancer

Castro-Oropeza

Vázquez-Santillán

Díaz-Gastelum

et al. 2020

Sci Rep

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Epidemiological studies indicate that obesity negatively affects the progression and treatment of cervical-uterine cancer. Recent evidence shows that a subpopulation of adipose-derived stem cells can alter cancer properties. In the present project, we described for the first time the impact of adipose-derived stem cells over the malignant behavior of cervical cancer cells. The transcriptome of cancer cells cultured in the presence of stem cells was analyzed using RNA-seq. Changes in gene expression were validated using digital-PCR. Bioinformatics tools were used to identify the main transduction pathways disrupted in cancer cells due to the presence of stem cells. In vitro and in vivo assays were conducted to validate cellular and molecular processes altered in cervical cancer cells owing to stem cells. Our results show that the expression of 95 RNAs was altered in cancer cells as a result of adipose-derived stem cells. Experimental assays indicate that stem cells provoke an increment in migration, invasion, angiogenesis, and tumorigenesis of cancer cells; however, no alterations were found in proliferation. Bioinformatics and experimental analyses demonstrated that the NF-kappa B signaling pathway is enriched in cancer cells due to the influence of adipose-derived stem cells. Interestingly, the tumor cells shift their epithelial to a mesenchymal morphology, which was reflected by the increased expression of specific mesenchymal markers. In addition, stem cells also promote a stemness phenotype in the cervical cancer cells. In conclusion, our results suggest that adipose-derived stem cells induce cervical cancer cells to acquire malignant features where NF-kappa B plays a key role.

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“…University and was conducted following the Declaration of Helsinki (certi cation no. Quick-PJ 2020- [11][12][13][14]. All patients provided written informed consent.…”

Section: Discussionmentioning

confidence: 99%

“…This work was approved by the Academic Committee of The First A liated Hospital of Anhui Medical University (certi cation no. Quick-PJ 2020- [11][12][13][14] and was conducted following the Declaration of Helsinki.…”

Section: Clinical Tissue Specimensmentioning

confidence: 99%

ITGA5 is a Prognostic Biomarker and Correlated with Immune Infiltration in Gastrointestinal Cancers

Zhu

Wang

Zhu

et al. 2020

Preprint

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Background: Integrin Subunit Alpha 5 (ITGA5), belongs to the integrin alpha chain family, is vital for promoting cancer cell invasion, metastasis. However, the correlation between ITGA5 expression and immune infiltration in gastrointestinal (GI) tumors remain unclear.Methods: The expression level of ITGA5 was detected by Oncomine and Tumor Immune Estimation Resource (TIMER). The association between ITGA5 and prognosis of patients was identified by Kaplan–Meier plotter, Gene Expression Profiling Interactive Analysis 2(GEPIA2) and PrognoScan. We evaluated the correlation between ITGA5 expression and immune infiltrating level via TIMER. Besides, TIMER, immunohistochemistry (IHC) staining and western blot were used to explore correlations between ITGA5 expression and markers of immune infiltrates cells. Furthermore, we constructed protein-protein interaction (PPI) network and performed functional enrichment by GeneMANIA and Metascape.Results: ITGA5 was generally overexpressed and correlated with worse prognosis in multiple types of GI tumors. In addition, ITGA5 expression levels was significantly associated with tumor purity and immune infiltration levels of different immune cells in GI tumors. Interestingly, immune markers for monocytes, tumor - associated macrophages (TAMs), macrophages 2 (M2) cells and T-helper 2 (Th2) cells were found to be significantly and positively correlated with ITGA5 expression levels in colon and gastric cancer. Results from IHC staining and western blot further proved that markers of Th2 and M2 cell were significantly increased in gastric cancer patients with high ITGA5 expression levels. Lastly, interaction network and function enrichment analysis revealed ITGA5 was mainly involved in “integrin mediated signaling pathway”, “leukocyte migration”, “cell-substrate adhesion”.Conclutions: Our study demonstrated that ITGA5 may act as an essential regulator of tumor immune cell infiltration and a valuable prognostic biomarker in GI tumors. Additional work is needed to fully elucidate the underlying mechanisms behind these observations.

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<p>Integrin α5/ITGA5 Promotes The Proliferation, Migration, Invasion And Progression Of Oral Squamous Carcinoma By Epithelial–Mesenchymal Transition</p>

Cited by 45 publications

References 25 publications

<p>miR-27b Suppresses Tongue Squamous Cell Carcinoma Epithelial–Mesenchymal Transition by Targeting ITGA5</p>

<p>miR-27b Suppresses Tongue Squamous Cell Carcinoma Epithelial–Mesenchymal Transition by Targeting ITGA5</p>

Adipose-derived mesenchymal stem cells promote the malignant phenotype of cervical cancer

ITGA5 is a Prognostic Biomarker and Correlated with Immune Infiltration in Gastrointestinal Cancers

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