&lt;p&gt;Interactive Network Platform Improves Compliance and Efficacy of Subcutaneous Immunotherapy for Patients with Allergic Rhinitis&lt;/p&gt;

Shen, Zhao; Tan, Guolin; Zhong, Zhuqing; Wang, Fang

doi:10.2147/ppa.s235711

Cited by 9 publications

(5 citation statements)

References 26 publications

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“…Epidemiological studies showed that AR affected at least half a billion people worldwide, and more than half of them were moderate to severe [ 3 ]. In China, the prevalence of AR even rises to 34.3% of the general population, and rates still continue to increase [ 4 , 5 ]. Although not life threatening, AR exhibits a negative influence on people's quality of life and their work production and brings about a high medical cost on individuals and society.…”

Section: Introductionmentioning

confidence: 99%

Identification of Novel Biomarkers for Evaluating Disease Severity in House-Dust-Mite-Induced Allergic Rhinitis by Serum Metabolomics

et al. 2021

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The aim of this study was to identify differences in serum metabolomics profiles of house-dust-mite (HDM)-induced allergic rhinitis (AR) patients compared to controls and to explore novel biomarkers reflecting disease severity. Serum samples were collected from 29 healthy controls and HDM-induced 72 AR patients, including 30 mild patients (MAR) and 42 moderate to severe AR patients (MSAR). Metabolomics detection was performed, and orthogonal partial least square discriminate analysis was applied to assess the differences between AR patients and controls and for subgroups based on disease severity. These analysis results successfully revealed distinct metabolite signatures which distinguished MAR patients and MSAR patients from controls. MSAR patients also could be discriminated from MAR patients based on their metabolic fingerprints. Most observed metabolite changes were related to glycine, serine, and threonine metabolism, pyrimidine metabolism, sphingolipid metabolism, arginine and proline metabolism, and fatty acid metabolism. Levels of sarcosine, sphingosine-1-phosphate, cytidine, and linoleic acid significantly correlated with the total nasal symptom score and visual analogue scale in AR patients. These results suggest that metabolomics profiling may provide novel insights into the pathophysiological mechanisms of HDM-induced AR and contribute to its evaluation of disease severity.

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Section: Introductionmentioning

confidence: 99%

Identification of Novel Biomarkers for Evaluating Disease Severity in House-Dust-Mite-Induced Allergic Rhinitis by Serum Metabolomics

et al. 2021

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“…A mean posttreatment difference of –1.5 (95% CI, –2.4 to –0.5; P = .002) was demonstrated for the EpSS and –1.7 (95% CI, –2.1 to –1.2; P < .00001) for the PSQI. Twenty-two studies 26-47 informed on the sleep domain of the RQLQ, while 14 studies 26,29-31,33,35-38,41-43,45,48 reported the total RQLQ after treatment. A mean posttreatment difference of –1.1 (95% CI, –1.2 to –0.9; P < .00001) was calculated for the RQLQ sleep domain and –1.4 (95% CI, –1.6 to –1.1; P < .00001) for RQLQ total.…”

Section: Resultsmentioning

confidence: 99%

“…00001) for the PSQI. Twenty‐two studies 26–47 informed on the sleep domain of the RQLQ, while 14 studies 26,29–31,33,35–38,41–43,45,48 reported the total RQLQ after treatment. A mean posttreatment difference of –1.1 (95% CI, –1.2 to –0.9; P <.…”

Section: Resultsmentioning

confidence: 99%

Impact of Treatment for Nasal Cavity Disorders on Sleep Quality: Systematic Review and Meta‐analysis

Fried

Yuen

Zhang

et al. 2021

Otolaryngol.--head neck surg.

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Objective To determine the impact of treatment for patients with nasal obstruction secondary to allergic rhinitis (AR) and nasal septal deviation (NSD) on sleep quality. Data Sources Primary studies were identified though PubMed, Scopus, Cochrane Library, and Web of Science. Review Methods A systematic review was performed by querying databases for articles published through August 2020. Studies were included that reported on objective sleep parameters (apnea-hypopnea index) and sinonasal and sleep-specific patient-reported outcome measures: Rhinoconjunctivitis Quality of Life Questionnaire, Nasal Obstruction Symptom Evaluation, Epworth Sleepiness Scale (EpSS), and Pittsburgh Sleep Quality Index (PSQI). Results The database search yielded 1414 unique articles, of which 28 AR and 7 NSD studies were utilized for meta-analysis. A total of 9037 patients (8515 with AR, 522 with NSD) were identified with a mean age of 35.0 years (35.3 for AR, 34.0 for NSD). Treatment for AR and NSD significantly improved subjective sleep quality. For AR, the EpSS mean difference was −1.5 (95% CI, –2.4 to –0.5; P = .002) and for the PSQI, –1.7 (95% CI, –2.1 to –1.2; P < .00001). For NSD, the EpSS mean difference was −3.2 (95% CI, –4.2 to –2.2; P < .00001) and for the PSQI, –3.4 (95% CI, –6.1 to –0.6; P = .02). Conclusion Subjective sleep quality significantly improved following treatment for AR and NSD. There were insufficient data to demonstrate that objective metrics of sleep quality similarly improved.

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“…In recent years, a study showed that self-media management can markedly improve the compliance of SLIT patients ( 18 ). At the same time, some studies illustrated that Internet-based interactive and mobile platforms can improve compliance with subcutaneous immunotherapy ( 19 , 20 ). Therefore, our team decided to use the mobile medical APP and WeChat to follow-up SLIT patients; compared with patients who received telephone follow-up in the past, we found that Internet follow-up can significantly improve the compliance of SLIT patients.…”

Section: Discussionmentioning

confidence: 99%

Internet follow-up can improve the compliance of sublingual immunotherapy in children with allergic rhinitis: a retrospective cohort study

Li¹,

Chen²,

Sun³

et al. 2023

Transl Pediatr

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Background: Sublingual immunotherapy (SLIT) is an effective approach for treating allergic rhinitis in children. Although the curative effect of SLIT is significant, the compliance of patients is poor because of the long treatment time. How to improve patients' compliance with SLIT is an important clinical problem faced by otolaryngology clinicians. At present, there are few studies on SLIT compliance. The present study aimed to analyze the related factors affecting SLIT compliance in children with AR.Methods: In total, 153 patients with AR who received SLIT were selected as the study objects. 17 patients were excluded from this study.The patients' demographic, follow-up methods, complications efficacy, compliance data, etc. were collected, and all patients were followed-up regularly. Patients were considered to have poor compliance when they stop taking medication of SLIT. Univariate and multivariable regression analyses were performed to analyze the independent factors influencing SLIT compliance. The odds ratios (ORs) and 95% confidence intervals (CIs) were computed by logistic regression.Results: A total of 136 patients were enrolled in this study. The baseline clinical factors of the two groups of follow-up methods were balanced and comparable. Among these, 35 patients (25.7%) ceased SLIT. There was a significant difference in compliance between the Internet follow-up group and the traditional follow-up group (P<0.001). Univariate logistic regression analysis showed that SLIT compliance was significantly related to residence (P<0.001), the caregiver's education level (P<0.001), follow-up methods (P<0.001), and whether the patient also had asthma (P<0.002). In the multivariate regression analysis, it was found that the follow-up methods (OR =7.60, 95% CI: 2.20-26.21, P=0.001) and caregiver's education level (OR =8.54, 95% CI: 3.04-23.95, P<0.001) were independent factors influencing SLIT compliance after adjusting for residence and whether the patient also had asthma.Conclusions: Our study found that the follow-up methods and the education level of caregivers were independent factors affecting SLIT compliance in children with AR. This study suggested that we should use the Internet follow-up method for children treated with SLIT in the future, and provides a basis for how to improve the compliance of SLIT in children with AR.

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<p>Interactive Network Platform Improves Compliance and Efficacy of Subcutaneous Immunotherapy for Patients with Allergic Rhinitis</p>

Cited by 9 publications

References 26 publications

Identification of Novel Biomarkers for Evaluating Disease Severity in House-Dust-Mite-Induced Allergic Rhinitis by Serum Metabolomics

Identification of Novel Biomarkers for Evaluating Disease Severity in House-Dust-Mite-Induced Allergic Rhinitis by Serum Metabolomics

Impact of Treatment for Nasal Cavity Disorders on Sleep Quality: Systematic Review and Meta‐analysis

Internet follow-up can improve the compliance of sublingual immunotherapy in children with allergic rhinitis: a retrospective cohort study

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