&lt;p&gt;Investigating the Potential of Phosphatidylcholine-Based Nano-Sized Carriers in Boosting the Oto-Topical Delivery of Caroverine: in vitro Characterization, Stability Assessment and ex vivo Transport Studies&lt;/p&gt;

Farrah, Amira Yousry; Al-mahallawi, Abdulaziz Mohsen; Basalious, Emad B.; Nesseem, Demiana I.

doi:10.2147/ijn.s259172

Cited by 11 publications

(5 citation statements)

References 24 publications

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“…During the last few years, researchers have studied nano-sized vesicles such as transfersomes and ethosomes for dermal/transdermal drug delivery. Transferosomes are flexible vesicles and the presence of a phospholipid bilayer and edge activator in the framework helps to promote drug permeation through the skin [50][51][52]. The phospholipid bilayer is destabilized and becomes more flexible with the help of edge activators.…”

Section: Resultsmentioning

confidence: 99%

Preparation and Characterization of Transethosome Formulation for the Enhanced Delivery of Sinapic Acid

Bin Jardan,

Ahad,

Raish

et al. 2023

Pharmaceutics

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Sinapic acid (SA) is a bioactive phenolic acid; its diverse properties are its anti-inflammatory, antioxidant, anticancer, and antibacterial activities. The bioactive compound SA is poorly soluble in water. Our goal was to formulate SA-transethosomes using thin-film hydration. The prepared formulations were examined for various parameters. In addition, the optimized formulation was evaluated for surface morphology, in-vitro penetration studies across the Strat M®, and its antioxidant activity. The optimized formulation (F5) exhibited 74.36% entrapment efficacy. The vesicle size, zeta potential, and polydispersity index were found to be 111.67 nm, −7.253 mV, and 0.240, respectively. The surface morphology showed smooth and spherical vesicles of SA-transethosomes. In addition, the prepared SA-transethosomes exhibited enhanced antioxidant activity. The SA-transethosomes demonstrated considerably greater penetration across the Strat M® membrane during the study. The flux of SA and SA-transethosomes through the Strat M® membrane was 1.03 ± 0.07 µg/cm2/h and 2.93 ± 0.16 µg/cm2/h. The enhancement ratio of SA-transethosomes was 2.86 ± 0.35 compared to the control. The SA-transethosomes are flexible nano-sized vesicles and are able to penetrate the entrapped drug in a higher concentration. Hence, it was concluded that SA-transethosome-based approaches have the potential to be useful for accentuating the penetrability of SA across the skin.

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Section: Resultsmentioning

confidence: 99%

Preparation and Characterization of Transethosome Formulation for the Enhanced Delivery of Sinapic Acid

Bin Jardan,

Ahad,

Raish

et al. 2023

Pharmaceutics

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“…The physical stability of the optimal PC was investigated to monitor the extent of vesicles’ growth, drug leakage or any other physical change. The optimal formula was stored at room temperature for 3 months and its stability was then evaluated by measuring and comparing the PS, PDI and EE% of the stored formula with the freshly prepared one (Farrah et al., 2020 ). In addition, the system was visually inspected for any particle aggregation or sedimentation.…”

Section: Methodsmentioning

confidence: 99%

Utilization of PEGylated cerosomes for effective topical delivery of fenticonazole nitrate: in-vitro characterization, statistical optimization, and in-vivo assessment

et al. 2020

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“…In the treatment of tinnitus, the study of Farrah et al [ 41 ] showed that a potential nano-scale carrier can be used to enhance the non-invasive transmission of the outer ear, providing a method for the treatment of tinnitus. Nano-carriers provide convenience for various drugs to enter the inner ear.…”

Section: Application Of Nanoparticles In Drug Carriermentioning

confidence: 99%

Nanomaterials for Inner Ear Diseases: Challenges, Limitations and Opportunities

Luo

Lin

et al. 2022

Materials

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The inner ear is located deep in the temporal bone and has a complex anatomy. It is difficult to observe and obtain pathological tissues directly. Therefore, the diagnosis and treatment of inner ear diseases have always been a major clinical problem. The onset of inner ear disease can be accompanied by symptoms such as hearing loss, dizziness and tinnitus, which seriously affect people’s lives. Nanoparticles have the characteristics of small size, high bioavailability and strong plasticity. With the development of related research on nanoparticles in inner ear diseases, nanoparticles have gradually become a research hotspot in inner ear diseases. This review briefly summarizes the research progress, opportunities and challenges of the application of nanoparticles in inner ear diseases.

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<p>Investigating the Potential of Phosphatidylcholine-Based Nano-Sized Carriers in Boosting the Oto-Topical Delivery of Caroverine: in vitro Characterization, Stability Assessment and ex vivo Transport Studies</p>

Cited by 11 publications

References 24 publications

Preparation and Characterization of Transethosome Formulation for the Enhanced Delivery of Sinapic Acid

Preparation and Characterization of Transethosome Formulation for the Enhanced Delivery of Sinapic Acid

Utilization of PEGylated cerosomes for effective topical delivery of fenticonazole nitrate: in-vitro characterization, statistical optimization, and in-vivo assessment

Nanomaterials for Inner Ear Diseases: Challenges, Limitations and Opportunities

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