&lt;p&gt;Juvenile-Onset Recurrent Respiratory Papillomatosis Diagnosis and Management – A Developing Country Review&lt;/p&gt;

Seedat, Riaz Y.

doi:10.2147/phmt.s200186

Cited by 31 publications

(38 citation statements)

References 85 publications

(167 reference statements)

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“…Diagnostics of RRP was based on the following criteria: (1) patients' complaints about permanent or recurrent hoarseness, (2) typical clinical signs of papillomas revealed during video laryngostroboscopy and direct microlaryngoscopy (exophytic, “cauliflower” shape appearing, sessile or pedunculated growths—pale pink with grayish tint, friable that tend to bleed at the least touch), 11‐13 and (3) histological identification of multiple “fronds” or finger‐like structures with a central vascular–connective core covered with stratified squamous epithelium and an intact basement membrane 11,21 . The final diagnosis of RRP was confirmed after histological examination of removed tissues at the Department of Pathology of LUHS.…”

Section: Methodsmentioning

confidence: 99%

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An Experimental Model of Human Recurrent Respiratory Papillomatosis: A Bridge to Clinical Insights

et al. 2020

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Objectives/Hypothesis To investigate the growth pattern of recurrent respiratory papilloma (RRP) implants on chicken embryo chorioallantoic membranes (CAMs) and to evaluate possible associations between the clinical course of the disease and the behavior of experimentally implanted RRP tumors. Study Design Experimental study. Methods Fresh 172 RRP tissue samples from 12 patients were implanted onto chick embryo CAMs. Morphological and morphometric analysis of the experimental CAM and chorionic epithelium was performed. The microvascular network of the CAM with the RRP implant was investigated under the effect of fluoresceinated anionic dextran. The peculiarities of the clinical course of the disease were evaluated. Results The implanted RRP tissue samples survived on CAMs in 86% of cases, retaining their essential morphologic characteristics and proliferative capacity of the original tumor. Implants induced thickening of both the CAM and the chorionic epithelium, but none of the RRP implants crossed the basement membrane of the hosting CAM. A “crawling film” of acellular material with newly formed papilloma sprouts located on the outer chorionic epithelium of the CAM was detected. Direct association between a recurrence rate of RRP and the number of newly formed papilloma sprouts around the implanted tumor on CAMs was revealed. Conclusion The chicken embryo CAM‐based model is appropriate for investigations of RRP and facilitates the understanding of tumor biology and the clinical course of the disease, thus providing the basis for further research and acceleration of the identification and development of new specific therapeutic compounds that limit the spread and recurrence of RRP. Level of Evidence N/A Laryngoscope, 131:E914–E920, 2021

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Section: Methodsmentioning

confidence: 99%

“…Currently, there is no curative treatment for RRP, and therefore, the main treatment option for RRP is surgical intervention primarily focused on maintaining airway patency and voice quality; often, multiple surgeries over a short period of time are required 11‐13 …”

Section: Introductionmentioning

confidence: 99%

An Experimental Model of Human Recurrent Respiratory Papillomatosis: A Bridge to Clinical Insights

et al. 2020

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“…Implementation of HPV vaccination programs in countries within the developing world may have the most profound effect on RRP eradication due to a higher incidence of JO RRP in low resource nations 34 . Despite the higher incidence of disease burden, many low income and middle‐income countries have not introduced the HPV vaccine as part of their national routine vaccination schedule 35 .…”

Section: Preventionmentioning

confidence: 99%

Recurrent respiratory papillomatosis: A 2020 perspective

Benedict

Derkay

2021

Laryngoscope Investig Oto

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Objective Despite recent advancement recurrent respiratory papillomatosis (RRP) remains a rare but challenging benign airway neoplasm. In recent years there has been significant shifts in incidence of this disease due to changes in vaccination and prevention for human papilloma virus (HPV) and its related pathology. This review will highlight the epidemiology, prevention and treatment of RRP. Methods The PubMed database was searched using relevant MeSH terms including “recurrent respiratory papillomatosis.” The titles and abstracts were reviewed to assess relevance and unrelated articles were excluded. A full‐text review for select articles was performed, the data and discussions were interpreted and synthesized to create a concise update on the management of RRP. Results With the increasing utilization of the 9‐valent and quadrivalent HPV vaccine in Australia, we have seen a significant decrease in the incidence of RRP. Preliminary data in the US shows a similar trend of decreased incidence after implementation of vaccination. Single dose Gardasil in developing countries has shown sustained immunization for at least 7 years. Preliminary clinical trials and retrospective studies have shown the HPV vaccine may have benefit as a treatment method in addition to prevention for HPV related diseases. Bevacizumab (Avastin), a VEGF monoclonal antibody, has shown promise as a systemic treatment for RRP. The Corona Virus Disease 2019 (COVID‐19) pandemic has affected perioperative management of RRP. Conclusion RRP continues to decline in incidence since the implementation of HPV vaccination. Advancement in the medical management including Bevacizumab show promise as an additional option for the management of RRP.

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“…Laryngeal papillomatosis is one of the global problems in the field of laryngology, since the exact etiopathogenesis of the disease is still not known. It is believed that about 10-60% of the world's population is infected with the human papillomavirus (HPV) latently, but not all get laryngeal papillomatosis, the causative agent of which is type 11 and 16 of this virus [1]. Juvenile respiratory laryngeal papillomatosis suggests that infection occurs secondarily, through the natural birth canal of the mother.…”

Section: Introductionmentioning

confidence: 99%

“…Only 3.3% of cases had lung damage. At the same time, the incidence of lung cancer among these patients was 16% [1]. It is also very rare to detect isolated papillomatosis of the trachea and lungs without involving the larynx [5].…”

Section: Introductionmentioning

confidence: 99%

A Patient with Juvenile Recurrent Respiratory Papillomatosis Complicated by Laryngeal Stenosis after Laryngeal Microsurgery: A Clinical Case

Turayeva

Papulova

Mukhamadiyeva

et al. 2022

Open Access Maced J Med Sci

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BACKGROUND: The relevance of the problem of juvenile respiratory papillomatosis lies in the recurrent course of the disease in young children. This can lead to the development of respiratory stenosis, requiring repeated, in some cases, monthly surgical treatments for endolaryngeal removal of papillomas, which sometimes leads to persistent scar stenosis of the larynx. We present clinical case of achieving remission of recurrent juvenile papillomatosis of the larynx. CLINICAL CASE: Patient, 5 years old, who applied in February 2016, was hospitalized in the ENT department with severe dyspnea, laryngoscopy revealed laryngeal papillomatosis with 3–4 grade stenosis. Over the past 10 months, the patient has undergone laryngeal surgery 6 times using cold instruments and a CO2 laser due to papillomatosis. Taking into account the recurrent nature of the course of the disease, the patient is administered to consult an allergist-immunologist. Based on the anamnesis and the results of the tests, the immunologist-allergist diagnosed: Primary immunodeficiency, unspecified (insufficiency in the production of specific antibodies), persistent allergic rhinitis, in the stage of incomplete remission and prescribed treatment. The patient was operated twice from 2017 to 2018 for a developed post-operative complication – cicatricial stenosis of the larynx. With these surgical repairs, no recurrence of laryngeal papillomatosis was detected. Furthermore, in 2021, according to endovideolaryngoscopy, remission was confirmed. R In this clinical case, we managed to achieve remission of laryngeal papillomatosis in a patient after surgery and treatment by an immunologist. Allergen elimination and immunocorrection helped us achieve deep remission. Surgical treatment eliminated laryngeal stenosis, recovering breathing and voice quality. Furthermore, this clinical case demonstrates the importance of studying the immune status in patients with laryngeal papillomatosis. CONCLUSION: The results obtained by us show the need for the use of immunomodulators in these patients. All children with prolonged hoarseness should undergo laryngoscopy, which will allow diagnosing laryngeal papillomatosis at earlier uncomplicated stages of the disease. Treatment of laryngeal papillomatosis should be comprehensive and in addition to surgical treatment should include differential immune correction. RESULTS AND DISCUSSION: In the above clinical case, we managed to achieve remission of laryngeal papillomatosis in a patient after surgery and treatment by an immunologist. Allergen elimination and immunocorrection helped us achieve deep remission. Surgical treatment eliminated laryngeal stenosis, recovering breathing and voice quality. Furthermore, this clinical case demonstrates the importance of studying the immune status in patients with laryngeal papillomatosis. The results obtained by us show the need for the use of immunomodulators in these patients. All children with prolonged hoarseness should undergo laryngoscopy, which will allow diagnosing laryngeal papillomatosis at earlier uncomplicated stages of the disease. Treatment of laryngeal papillomatosis should be comprehensive and in addition to surgical treatment should include differential immune correction.

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<p>Juvenile-Onset Recurrent Respiratory Papillomatosis Diagnosis and Management – A Developing Country Review</p>

Cited by 31 publications

References 85 publications

An Experimental Model of Human Recurrent Respiratory Papillomatosis: A Bridge to Clinical Insights

An Experimental Model of Human Recurrent Respiratory Papillomatosis: A Bridge to Clinical Insights

Recurrent respiratory papillomatosis: A 2020 perspective

A Patient with Juvenile Recurrent Respiratory Papillomatosis Complicated by Laryngeal Stenosis after Laryngeal Microsurgery: A Clinical Case

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