&lt;p&gt;Lack of association between &lt;em&gt;ALOX5AP&lt;/em&gt; genetic polymorphisms and risk of ischemic stroke: evidence from meta-analyses&lt;/p&gt;

Zheng, Jinghui; Ning, Guilan; Xu, Wenhua; Wu, Xiaoyun; Ma, Xianlei

doi:10.2147/ndt.s182674

Cited by 5 publications

(1 citation statement)

References 41 publications

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“…In addition, genetic variation in the ALOX5AP gene contributes to the risk of coronary heart disease (CHD) in patients with familial hypercholesterolemia [ 66 ]. It should be noted that analysis of ALOX5AP polymorphisms showed different evidence for associations with the risk of ischemic stroke [ 67 , 68 , 69 , 70 , 71 , 72 ].…”

Section: Genetic Contribution Of the Lipoxygenase Pathwaymentioning

confidence: 99%

Genetic and Epigenetic Regulation of Lipoxygenase Pathways and Reverse Cholesterol Transport in Atherogenesis

Kotlyarov

2022

Genes

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Atherosclerosis is one of the most important medical and social problems of modern society. Atherosclerosis causes a large number of hospitalizations, disability, and mortality. A considerable amount of evidence suggests that inflammation is one of the key links in the pathogenesis of atherosclerosis. Inflammation in the vascular wall has extensive cross-linkages with lipid metabolism, and lipid mediators act as a central link in the regulation of inflammation in the vascular wall. Data on the role of genetics and epigenetic factors in the development of atherosclerosis are of great interest. A growing body of evidence is strengthening the understanding of the significance of gene polymorphism, as well as gene expression dysregulation involved in cross-links between lipid metabolism and the innate immune system. A better understanding of the genetic basis and molecular mechanisms of disease pathogenesis is an important step towards solving the problems of its early diagnosis and treatment.

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Section: Genetic Contribution Of the Lipoxygenase Pathwaymentioning

confidence: 99%

Genetic and Epigenetic Regulation of Lipoxygenase Pathways and Reverse Cholesterol Transport in Atherogenesis

Kotlyarov

2022

Genes

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ALOX5AP is a new prognostic indicator in acute myeloid leukemia

Chen,

Wen,

Zhao

et al. 2023

Discov Onc

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Background The overexpression of ALOX5AP has been observed in many types of cancer and has been identified as an oncogene. However, its role in acute myeloid leukemia (AML) has not been extensively studied. This study aimed to identify the expression and methylation patterns of ALOX5AP in bone marrow (BM) samples of AML patients, and further explore its clinical significance. Methods Eighty-two de novo AML patients and 20 healthy donors were included in the study. Meanwhile, seven public datasets from Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) were included to confirm the alteration of ALOX5AP. Receiver operating characteristic (ROC) curve analysis was applied to determine the discriminative capacity of ALOX5AP expression to discriminate AML. The prognostic value of ALOX5AP was identified by the Kaplan–Meier method and log-rank test. It was further validated in four independent cohorts (n = 1186). Significantly different genes associated with ALOX5AP expression were subsequently compared by LinkedOmics, and Metascape database. Results The level of ALOX5AP expression was significantly increased in bone marrow cells of AML patients compared with healthy donors (P < 0.05). ROC curve analysis suggested that ALOX5AP expression might be a potential biomarker to discriminate AML from controls. ALOX5AP overexpression was associated with decreased overall survival (OS) in AML according to the TCGA data (P = 0.006), which was validated by other four independent cohorts. DNA methylation levels of ALOX5AP were significantly lower in AML patients compared to normal samples (P < 0.05), as confirmed in the Diseasemeth database and the independent cohort GSE63409. ALOX5AP level was positively associated with genes with proleukemic effects such as PAX2, HOX family, SOX11, H19, and microRNAs that act as oncogenes in leukemia, such as miR125b, miR-93, miR-494, miR-193b, while anti-leukemia-related genes and tumor suppressor microRNAs such as miR-582, miR-9 family and miR-205 were negatively correlated. Conclusion ALOX5AP overexpression, associated with its hypomethylation, predicts poorer prognosis in AML.

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