&lt;p&gt;lncRNA FLVCR-AS1 promotes osteosarcoma growth by targeting miR381-3p/CCND1&lt;/p&gt;

Yang, Guang; He, Fei; Duan, Hao; Shen, Jianlin; Dong, Qirong

doi:10.2147/ott.s214813

Cited by 11 publications

(8 citation statements)

References 44 publications

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“…Recent studies demonstrated that lncRNAs play an important role in the development of tumors. Relevant studies have detected abnormal lncRNA expression in many cancer types, which is closely related to cancer progression [ 22 , 23 , 24 ]. Therefore, specific lncRNAs can be used as independent diagnostic and prognostic markers in cancer.…”

Section: Discussionmentioning

confidence: 99%

Four long noncoding RNAs act as biomarkers in lung adenocarcinoma

Zhang

Yang

et al. 2021

Open Medicine

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Introduction Lung adenocarcinoma (LUAD) is currently one of the most common malignant tumors worldwide. However, there is a lack of long noncoding RNA (lncRNA)-based effective markers for predicting the prognosis of LUAD patients. We identified four lncRNAs that can effectively predict the prognosis of LUAD patients. Methods We used data gene expression profile for 446 patients from The Cancer Genome Atlas database. The patients were randomly divided into a training set and a test set. Significant lncRNAs were identified by univariate regression. Then, multivariate regression was used to identify lncRNAs significantly associated with the survival rate. We constructed four-lncRNA risk formulas for LUAD patients and divided patients into high-risk and low-risk groups. Identified lncRNAs subsequently verified in the test set, and the clinical independence of the lncRNA model was evaluated by stratified analysis. Then mutated genes were identified in the high-risk and low-risk groups. Enrichment analysis was used to determine the relationships between lncRNAs and co-expressed genes. Finally, the accuracy of the model was verified using external database. Results A four-lncRNA signature (AC018629.1, AC122134.1, AC119424.1, and AL138789.1) has been verified in the training and test sets to be significantly associated with the overall survival of LUAD patients. Conclusions The present study demonstrated that identified four-lncRNA signature can be used as an independent prognostic biomarker for the prediction of survival of LUAD patients.

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Section: Discussionmentioning

confidence: 99%

Four long noncoding RNAs act as biomarkers in lung adenocarcinoma

Zhang

Yang

et al. 2021

Open Medicine

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“…20 A few lncRNAs involved in the tumorigenesis of osteosarcoma have been identified. [21][22][23][24] For instance, lncRNA PCAT6 could sponge miR-185-5p to promote tumor progression of osteosarcoma through TGFβpathway, 25 LINC01278 could favor the progression of osteosarcoma via miR-133a-3p/PTHR1 pathway. 26 In this study, we focused on the specific tumorigenesis mechanism induced by lncRNA 691 and its ceRNA, miR-9-5p in osteosarcoma.…”

Section: Discussionmentioning

confidence: 99%

<p>Long Non-Coding RNA 691 Regulated PTEN/PI3K/AKT Signaling Pathway in Osteosarcoma Through miRNA-9-5p</p>

Yao¹,

Ni²,

Liu³

2020

OTT

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Background: Large amounts of researches indicate that non-coding RNAs play a crucial role in many malignancies. However, the potential mechanisms of non-coding RNAs involved in osteosarcoma tumorigenesis remain elusive. Materials and Methods: The expression of long non-protein coding RNA 691 (lncRNA 691) in cell lines and paired osteosarcoma tissues was compared by qRT-PCR assay. Then, we explored the tumor suppressor function of lncRNA 691 with MTS and colony formation assay. Flow cytometry results showed lncRNA 691 can enhance cell apoptosis. Then, we predicted and verified the negative regulation relationship with miRNA and the miRNA's target gene. Lastly, we revealed the tumorigenesis function of lncRNA-691/miRNA/target gene axis in osteosarcoma. Results: In our study, we disclosed that lncRNA 691 had low expression levels in osteosarcoma cell lines and tissues. Overexpression of lncRNA 691 could suppress the cell proliferation and induce cell apoptosis in MG-63 cell line. Then, bioinformatics analyses were performed and miR-9-5p was found to negatively regulate the lncRNA 691 expression and promote the osteosarcoma tumorigenesis in vitro. PTEN was predicted as the target gene of miR-9-5p. Luciferase reporter assay and RIP assay demonstrated the regulatory network of lncRNA 691/miR-9-5p/PTEN. We revealed that PTEN was downregulated by the overexpression of miR-9-5p and upregulated by the overexpression of lncRNA 691. At last, the apoptosis-associated protein of the lncRNA 691/miR-9-5p/PTEN/PI3K/AKT was further demonstrated. Conclusion: LncRNA 691/miR-9-5p could regulate the tumorigenesis by regulating the PTEN/PI3K/AKT signal pathway in osteosarcoma.

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“…Previous studies suggested that miR-381 had a great effect on cell growth, migration or apoptosis (Jin et al, 2020;Yang et al, 2020;Fang et al, 2021). To determine the role that miR-381 plays in RPCs, we first evaluated the endogenous expression levels of miR-381-3p during RPCs differentiation.…”

Section: Endogenous Expression Levels Of Mir-381-3p and Hes1 In The P...mentioning

confidence: 99%

miR-381-3p Cooperated With Hes1 to Regulate the Proliferation and Differentiation of Retinal Progenitor Cells

Wang

Sun

et al. 2022

Front. Cell Dev. Biol.

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Retinal progenitor cells (RPCs) transplantation has become a promising therapy for retinal degeneration, which is a major kind of ocular diseases causing blindness. Since RPCs have limited proliferation and differentiation abilities toward retinal neurons, it is urgent to resolve these problems. MicroRNAs have been reported to have vital effects on stem cell fate. In our study, the data showed that overexpression of miR-381-3p repressed Hes1 expression, which promoted RPCs differentiation, especially toward neuronal cells, and inhibited RPCs proliferation. Knockdown of endogenous miR-381-3p increased Hes1 expression to inhibit RPCs differentiation and promote proliferation. In addition, a luciferase assay demonstrated that miR-381-3p directly targeted the Hes1 3’ untranslated region (UTR). Taken together, our study demonstrated that miR-381-3p regulated RPCs proliferation and differentiation by targeting Hes1, which provides an experimental basis of RPCs transplantation therapy for retinal degeneration.

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<p>lncRNA FLVCR-AS1 promotes osteosarcoma growth by targeting miR381-3p/CCND1</p>

Cited by 11 publications

References 44 publications

Four long noncoding RNAs act as biomarkers in lung adenocarcinoma

Four long noncoding RNAs act as biomarkers in lung adenocarcinoma

<p>Long Non-Coding RNA 691 Regulated PTEN/PI3K/AKT Signaling Pathway in Osteosarcoma Through miRNA-9-5p</p>

miR-381-3p Cooperated With Hes1 to Regulate the Proliferation and Differentiation of Retinal Progenitor Cells

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