&lt;p&gt;LncRNA PSMA3-AS1 Promotes Lung Cancer Growth and Invasion via Sponging MiR-4504&lt;/p&gt;

Li, Fangfang; Yu, Liu; Zhu, Jun

doi:10.2147/cmar.s253575

Cited by 15 publications

(18 citation statements)

References 25 publications

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“…Its expression could be utilized for independently predicting patients' outcomes. Previously, Xu et al reported that circulating PSMA3-AS1 [11]. As reported in the study of Wang et al, PSMA3-AS1 expression was in correlation to stage, lymph node metastases, and OS in non-small-cell lung carcinoma [16].…”

Section: Discussionmentioning

confidence: 70%

“…As reported in previous research, PSMA3-AS1 functions as an oncogenic lncRNA [9]. PSMA3-AS1 upregulation may facilitate the progress of multiple myeloma [9], esophageal cancer [10], lung cancer [11], colorectal cancer [12], and glioma [13]. Mechanically, PSMA3-AS1 accelerates lung cancer growth and invasion through sponging miR-4504 [11].…”

Section: Introductionmentioning

confidence: 80%

“…PSMA3-AS1 upregulation may facilitate the progress of multiple myeloma [9], esophageal cancer [10], lung cancer [11], colorectal cancer [12], and glioma [13]. Mechanically, PSMA3-AS1 accelerates lung cancer growth and invasion through sponging miR-4504 [11]. PSMA3-AS1 as a sponge of miR-4429 induces colorectal cancer cell migration and invasion [12].…”

Section: Introductionmentioning

confidence: 99%

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Targeting lncRNA PSMA3-AS1, a Prognostic Marker, Suppresses Malignant Progression of Oral Squamous Cell Carcinoma

et al. 2021

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Objective. Oral squamous cell carcinoma (OSCC) represents the most common maxillofacial malignancy. This study elucidated the clinicopathological value and molecular mechanisms of PSMA3 antisense RNA 1 (PSMA3-AS1) in OSCC. Methods. Totally, 135 OSCC patients were recruited. PSMA3-AS1 expression and its prognostic value were assessed in this cohort. si-PSMA3-AS1 was transfected into HN4 and CAL-27 OSCC cells. Then, cell proliferation was evaluated by CCK-8, colony formation, and EdU staining. Migration and invasion were investigated through wound healing, transwell, and western blot. The PSMA3-AS1/miR-136-5p and miR-136-5p/FN1 interactions were validated by dual luciferase report, real-time quantitative polymerase chain reaction (RT-qPCR), and western blot. Results. PSMA3-AS1 upregulation was determined in OSCC tissues. The upregulation indicated pessimistic patients’ outcomes. Multivariate Cox regression analyses confirmed PSMA3-AS1 as an independent prognostic indicator. Its upregulation was also found in OSCC cells. Under transfection with si-PSMA3-AS1, proliferation, migration, and invasion were all restrained in HN4 and CAL-27 OSCC cells. Furthermore, its knockdown induced the increase in E-cadherin expression and the reduction in N-cadherin and Vimentin expression. PSMA3-AS1 was a sponge of miR-136-5p. Mutual inhibition was found between two and the interactions were confirmed by dual luciferase report. It was confirmed that FN1 was a target of miR-136-5p. FN1 expression was increased by miR-136-5p inhibitors, which was lessened by si-PSMA3-AS1 cotransfection. Conclusion. Collectively, PSMA3-AS1 as a risk factor facilitated malignant behaviors of OSCC cells, related to the miR-136-5p/FN1 axis. Hence, PSMA3-AS1 as a potential therapeutic target for OSCC deserved further exploration.

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Section: Discussionmentioning

confidence: 70%

Section: Introductionmentioning

confidence: 80%

Section: Introductionmentioning

confidence: 99%

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Targeting lncRNA PSMA3-AS1, a Prognostic Marker, Suppresses Malignant Progression of Oral Squamous Cell Carcinoma

et al. 2021

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“…LncRNAs play a role of oncogene or tumor suppressor gene in CCA [ 18 ]. Some researches have demonstrated that PSMA3-AS1 exerted cancer-promoting function in some types of tumors [ 19 ]. Nevertheless, specific action of PSMA3-AS1 in CCA is unknown.…”

Section: Discussionmentioning

confidence: 99%

PSMA3-AS1 induced by transcription factor PAX5 promotes cholangiocarcinoma proliferation, migration and invasion by sponging miR-376a-3p to up-regulate LAMC1

Sun

et al. 2022

Aging

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Long noncoding RNAs (lncRNAs) have been reported to exhibit a crucial regulatory role in tumor progression, including cholangiocarcinoma (CCA). As a promising lncRNA, proteasome 20S subunit alpha 3 antisense RNA 1 (PSMA3-AS1) is involved in development of various tumors. However, the role and function of PSMA3-AS1 in CCA remain unclear. The aim of this study is to examine the expression, function, mechanism, and clinical significance of PSMA3-AS1 in CCA development. By TCGA database analysis, we found that PSMA3-AS1 was overexpressed in CCA. Consistent with the TCGA analysis, PSMA3-AS1 was significantly overexpressed in CCA tissues and cells by RT-qPCR. Upregulated PSMA3-AS1 was related to lymph node invasion, advanced TNM stage and poor survival, and was an independent risk factor of prognosis for CCA patients. Functionally, CCK-8, EdU and colony formation assays confirmed that upregulated PSMA3-AS1 promoted CCA cell proliferation, whereas downregulated PSMA3-AS1 inhibited proliferation. This result was further confirmed by subcutaneous tumor formation in nude mice. Wound healing and transwell assays confirmed that increased PSMA3-AS1 promoted CCA cell migration and invasion, whereas decreased PSMA3-AS1 inhibited these biological phenotypes. In addition, PSMA3-AS1 promoted the EMT process of CCA by downregulating E-cadherin and upregulating N-cadherin and vimentin. Mechanistically, transcription factor PAX5 bound to the promoter region of PSMA3-AS1 and promoted its transcription. Simultaneously, PSMA3-AS1 primarily localized in the cytoplasm could competitively bind miR-376a-3p to upregulate LAMC1, thereby accelerating CCA progression. This study uncovers that PSMA3-AS1 functions as a cancer-promoting gene in CCA, and PAX5/PSMA3-AS1/miR-376a-3p/LAMC1 axis plays a vital role in CCA development.

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“…The expression of the lncRNA PSMA3-AS1 (PSMA3 antisense RNA 1) was also upregulated in lung cancer tissues and cell lines, and was positively correlated with clinical stage and metastasis. The overexpression of PSMA3-AS1 resulted in poor prognosis of lung cancer patients, and knockdown of PSMA3-AS1 inhibited the proliferation, migration, and invasion of lung cancer cells [ 72 ].…”

Section: Reviews Of Recent Studies For Long Non-coding Rnasmentioning

confidence: 99%

The Role of Sex-specific Long Non-coding RNAs in Cancer Prevention and Therapy

Song

Kim

2021

J Cancer Prev

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The functions of a large number of non-coding genes in human DNA have yet to be accurately identified. Long non-coding RNA (lncRNA) measuring 10 kb or less in length regulates transcription or post-transcriptional events. The lncRNAs have attracted increased attention of researchers in recent years. In this review, we summarize the recently published lncRNAs which are known to influence cancer development and progression. We also discuss recent studies investigating tumor-specific lncRNA expression. These lncRNAs provide very useful information that allows prediction of the degree of malignancy and a survival rate in cancer patients as clinically relevant biomarkers. Because symptoms and progression of cancer differ from onset to death between males and females, it is important to consider the gender of the patient when diagnosing cancer and predicting the progression. Considering the importance of gender difference, we also examine the influence of sex hormones involved in the expression and regulation of lncRNAs as biomarkers. Many of the lncRNAs examined in this review have been studied in cancers occurring in the female or male reproductive organs, but the association between lncRNAs and sex hormones has also been reported in common organs such as the lung, renal and colon. Although lncRNAs have not yet been widely used as definitive cancer indicators, recent studies have demonstrated the potential role of lncRNAs as biomarkers and therapeutic targets reflecting sex-specificity in a number of different cancers.

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<p>LncRNA PSMA3-AS1 Promotes Lung Cancer Growth and Invasion via Sponging MiR-4504</p>

Cited by 15 publications

References 25 publications

Targeting lncRNA PSMA3-AS1, a Prognostic Marker, Suppresses Malignant Progression of Oral Squamous Cell Carcinoma

Targeting lncRNA PSMA3-AS1, a Prognostic Marker, Suppresses Malignant Progression of Oral Squamous Cell Carcinoma

PSMA3-AS1 induced by transcription factor PAX5 promotes cholangiocarcinoma proliferation, migration and invasion by sponging miR-376a-3p to up-regulate LAMC1

The Role of Sex-specific Long Non-coding RNAs in Cancer Prevention and Therapy

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