2020
DOI: 10.2147/cmar.s264681
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<p>Long Non-Coding RNA LINC00491 Contributes to the Malignancy of Non-Small-Cell Lung Cancer via Competitively Binding to microRNA-324-5p and Thereby Increasing Specificity Protein 1 Expression</p>

Abstract: Background A long non-coding RNA termed as long intergenic non-protein coding RNA 491 (LINC00491) has been validated as an oncogene to promote cancer progression in colon adenocarcinoma. The goal of this study was to determine the expression and carcinogenic functions of LINC00491 in non-small-cell lung cancer (NSCLC). Besides, it was aimed to understand how LINC00491 affects the malignant processes of NSCLC cells. Methods The expression of LINC00491 in NSCLC was invest… Show more

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Cited by 6 publications
(4 citation statements)
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References 39 publications
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“… 10 LncRNA LINC00491 promotes lung cancer proliferation, migration and invasion by sponging miR-324 to facilitate SP1 expression. 11 Thus, it is important to determine the correlation between lncRNA and RB progression.…”
Section: Introductionmentioning
confidence: 99%
“… 10 LncRNA LINC00491 promotes lung cancer proliferation, migration and invasion by sponging miR-324 to facilitate SP1 expression. 11 Thus, it is important to determine the correlation between lncRNA and RB progression.…”
Section: Introductionmentioning
confidence: 99%
“…LINC00491 has already been recognised as hub oncogene in non-small-cell lung cancer (NSCLC) and CA, but it has never been explored and validated in HCC [ 9 , 10 ]. Therefore, the role of LINC00491 with regard to HCC requires further assessment.…”
Section: Resultsmentioning
confidence: 99%
“…However, evidence suggests a specific role for SP1 in regulating genes’ hallmarks of cancer and genes required for development and differentiation [ 15 ]. SP-1 is a gene downstream of the lncRNA/miR/mRNA axis and has been found to be regulated by lncRNA-miR crosstalk in various cancers, including lung adenoma and non-small cell lung cancer [ 16 , 17 ]. It is known that the activity of SP-1 regulates lncRNA in breast and colorectal cancer and promotes chemical resistance and cancer progression [ 18 , 19 ].…”
Section: Introductionmentioning
confidence: 99%