&lt;p&gt;Long Non-Coding RNAs in Brown Adipose Tissue&lt;/p&gt;

Lai, Songjia; Du, Kun; Shi, Yu; Cao, Li; Wang, Guoze; Hu, Shiyan; Jia, Xianbo; Wang, Jie; Chen, Shiyi

doi:10.2147/dmso.s264830

Cited by 9 publications

(8 citation statements)

References 89 publications

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“…We classified DELs into different clusters using the k-means method. The BAT is specialized for energy expenditure and heat generation, which depends on the function of mitochondria [45]. Purine nucleotides proved a constitutive inhibitor of UCP1 mediated proton conductance of the mitochondrial inner membrane and constituted the default shut-off mechanism in the absence of thermogenic demand [46].…”

Section: Discussionmentioning

confidence: 99%

De Novo Reconstruction of Transcriptome Identified Long Non-Coding RNA Regulator of Aging-Related Brown Adipose Tissue Whitening in Rabbits

Xue

et al. 2021

Biology

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Brown adipose tissues (BATs) convert to a “white-like” phenotype with age, which is also known as “aging-related BAT whitening (ARBW)”. Emerging evidence suggested that long non-coding RNAs (lncRNAs) were widely involved in adipose biology. Rabbit is an ideal model for studying the dynamics of ARBW. In this study, we performed histological analysis and strand-specific RNA-sequencing (ssRNA-seq) of rabbit interscapular adipose tissues (iATs). Our data indicated that the rabbit iATs underwent the ARBW from 0 days to 2 years and a total of 2281 novel lncRNAs were identified in the iATs. The classical rabbit BATs showed low lncRNA transcriptional complexity compared to white adipose tissues (WATs). A total of 631 differentially expressed lncRNAs (DELs) were identified in four stages. The signal pathways of purine metabolism, Wnt signaling pathway, peroxisome proliferator-activated receptor (PPAR) signaling pathway, cyclic guanosine monophosphate (cGMP)/cGMP-dependent protein kinase (cGMP-PKG) signaling pathway and lipid and atherosclerosis were significantly enriched by the DELs with unique expression patterns. A novel lncRNA that was highly expressed in the iATs of aged rabbits was validated to impair brown adipocyte differentiation in vitro. Our study provided a comprehensive catalog of lncRNAs involved in ARBW in rabbits, which facilitates a better understanding of adipose biology.

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Section: Discussionmentioning

confidence: 99%

De Novo Reconstruction of Transcriptome Identified Long Non-Coding RNA Regulator of Aging-Related Brown Adipose Tissue Whitening in Rabbits

Xue

et al. 2021

Biology

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“…lncRNA-BATE10 is BAT-specific and is a member of the lncRNA-BATE family. lncRNA-BATE10 is transcribed from four exons in an intergenic region of mouse chromosome 18 and is ~1.7 kb in length (21). lncRNA-BATE10 expression in white adipose tissue is increased by exposure to cold, β-adrenergic agonists and intense physical exercise (26).…”

Section: Discussionmentioning

confidence: 99%

“…They regulate gene expression by functioning as microRNA sponges and by affecting transcription, splicing, and translation (20). Recent research has also demonstrated that lncRNAs are involved in brown adipogenesis, the browning of white adipose tissue, and brown adipose thermogenesis (21). These lncRNAs include lncRNA-BATE1, lncRNA-BATE10, AK079912, Blnc1, H19, Lnc-Uc.417 and Lnc-dPrdm16 (21).…”

Section: Introductionmentioning

confidence: 99%

Porphyromonas gingivalis‑derived lipopolysaccharide inhibits brown adipocyte differentiation via lncRNA‑BATE10

Zheng

Zhang³

et al. 2022

Exp Ther Med

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Epidemiological studies have suggested an association between obesity and periodontal disease. Brown adipose tissue (BAT) has an anti-obesity effect. However, the effects of periodontitis on obesity and BAT remain unclear. Therefore, the present study aimed to determine the effects of lipopolysaccharide derived from Porphyromonas gingivalis (P. gingivalis LPS) on brown adipocytes. For this purpose, the present study examined the effects of the intravenous administration of Porphyromonas gingivalis (P. gingivalis) in mice, the treatment of brown adipocytes with P. gingivalis LPS during differentiation, and the administration of small interfering RNA targeting interferon on brown preadipocytes by assessing the expression of genes involved in differentiation, using a long non-coding (lnc)RNA, and pro-inflammatory factors using reverse transcription-quantitative PCR. In addition, the accumulation of lipid droplets was examined using Oil Red O staining. P. gingivalis LPS reduced the expression of uncoupling protein 1 (UCP1) and lncRNA-BATE10 in brown adipocytes during differentiation. Consistent with this finding, P. gingivalis reduced UCP1 and lncRNA-BATE10 expression in the BAT of mice. lncRNA-BATE10 may thus be involved in the regulation of UCP1 expression that occurs during the differentiation of brown adipocytes treated with P. gingivalis LPS. Thus, P. gingivalis LPS may inhibit BAT differentiation by reducing lncRNA-BATE10 expression.

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“…The molecular regulation by RNAs is not limited to small RNAs and increasing evidence has suggested that long non-coding RNAs (lncRNAs) also play a role in beige and brown development and function [ 171 ]. LncRNAs are RNA molecules with more than 200 nucleotides in length and their mechanism of action includes chromatin remodeling, chromatin interactions, natural antisense transcripts (NATs], as well as interacting with RNA binding proteins in the cytosol [ 172 ].…”

Section: Molecular Circuits Regulating Brown and Beige Adipose Tissue Development And Functionmentioning

confidence: 99%

Thermogenic Fat: Development, Physiological Function, and Therapeutic Potential

Brandão

Poojari

Rabiee

2021

IJMS

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The concerning worldwide increase of obesity and chronic metabolic diseases, such as T2D, dyslipidemia, and cardiovascular disease, motivates further investigations into preventive and alternative therapeutic approaches. Over the past decade, there has been growing evidence that the formation and activation of thermogenic adipocytes (brown and beige) may serve as therapy to treat obesity and its associated diseases owing to its capacity to increase energy expenditure and to modulate circulating lipids and glucose levels. Thus, understanding the molecular mechanism of brown and beige adipocytes formation and activation will facilitate the development of strategies to combat metabolic disorders. Here, we provide a comprehensive overview of pathways and players involved in the development of brown and beige fat, as well as the role of thermogenic adipocytes in energy homeostasis and metabolism. Furthermore, we discuss the alterations in brown and beige adipose tissue function during obesity and explore the therapeutic potential of thermogenic activation to treat metabolic syndrome.

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<p>Long Non-Coding RNAs in Brown Adipose Tissue</p>

Cited by 9 publications

References 89 publications

De Novo Reconstruction of Transcriptome Identified Long Non-Coding RNA Regulator of Aging-Related Brown Adipose Tissue Whitening in Rabbits

De Novo Reconstruction of Transcriptome Identified Long Non-Coding RNA Regulator of Aging-Related Brown Adipose Tissue Whitening in Rabbits

Porphyromonas gingivalis‑derived lipopolysaccharide inhibits brown adipocyte differentiation via lncRNA‑BATE10

Thermogenic Fat: Development, Physiological Function, and Therapeutic Potential

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