<p><em>Helicobacter pylori</em>, Endoscopic, And Histologic Features Among Kidney Transplant Candidates In Southern Iran</p>

Abstract

BackgroundThe risks of gastrointestinal disorders and cancer are higher in chronic kidney disease (CKD) patients than the general population. There are only a few published reports on the association of helicobacter pylori (H. pylori) infection, endoscopic findings, and histology in these patients. This study was designed to address these controversial topics among kidney transplant candidates as the first study in southern Iran.Patients and methodsIn this cross-sectional study, patients undergoing renal transplantation in the largest center of southern Iran during 2016–2017 were evaluated for the frequency of H. pylori infection, endoscopic findings, and histology. Gastric endoscopic findings (normal, abnormal non-ulcerative, ulcerative) and histological findings of gastric biopsy (normal/non-significant, inflammation, premalignant lesions (PMLs), malignant lesions) were studied.ResultsIn total, 293 patients underwent endoscopy for transplant work up. The mean age (SD) was 47.37 (13.14) years. The most common endoscopic finding was abnormal gastric lesions. Overall, 78.8% patients had abnormal gastric histologic findings, of which 6.1% had PMLs. There was no significant association between laboratory data of patients with H. pylori infection. Of these, 147 (50.2%) patients were positive and the others were H. Pylori negative. Positive H. pylori infection was significantly associated with gastric ulcerative lesions. Positive H. pylori infection was also strongly associated with inflammation (P<0.01), but not significantly associated with PMLs (P=0.99) in gastric histology.ConclusionThe present study showed that abnormal endoscopic and histologic findings as well as positive H. pylori infection were observed in a large number of kidney transplant candidates, so upper endoscopy with biopsy is an acceptable procedure for these patients. However, further studies are recommended to determine the relationship of H. pylori with abnormal endoscopic and histologic findings considering other confounding factors in kidney transplant candidates as well as the efficacy of H. pylori eradication therapy to improve these abnormal findings.

Review: Extragastric diseases andHelicobacter pylori

“…58 In a cross-sectional study including 293 Iranian patients undergoing kidney transplant, 50% of them were H pylori positive by gastric biopsy testing. 59 Interestingly, H pylori infection could be a potential risk factor for renal damage in patients with peptic ulcer, as a positive association between this bacterium and altered albumin-to-creatinine ratio (P = .025) was found, and a significant decrease of the latter occurred after H pylori eradication (P < .01). 60 epitope spreading, and polyclonal activation.…”

“…A systematic review with meta‐analysis, including 47 studies, recently reported a prevalence of H pylori infection in 48% of patients with chronic kidney disease (CKD) compared to 59% of healthy controls, with an OR of 0.64 (95% CI, 0.52‐0.79) 58 . In a cross‐sectional study including 293 Iranian patients undergoing kidney transplant, 50% of them were H pylori positive by gastric biopsy testing 59 . Interestingly, H pylori infection could be a potential risk factor for renal damage in patients with peptic ulcer, as a positive association between this bacterium and altered albumin‐to‐creatinine ratio ( P = .025) was found, and a significant decrease of the latter occurred after H pylori eradication ( P < .01) 60 …”

&lt;i&gt;Helicobacter Pylori&lt;/i&gt; Infection and Gastroduodenal Lesions in Patients with Chronic Kidney Disease: A Comparative Study

“…Although evidence demonstrating an association between H. pylori infection and renal disease remain unknown. About 25% -75% of chronic kidney disease (CKD) patients suffer from multiple gastrointestinal lesions and their complications (gastric erosions, peptic ulcer disease, angiodysplasia, and gastrointestinal bleeding) [14] [15] [16]. H. pylori plays a major role in the genesis of many gastrointestinal conditions both in individuals with normal renal function and CKD.…”

Helicobacter pylori infection is associated with elevated galactose-deficient IgA1 in IgA nephropathy

“…pylori, a gram-negative bacterium, colonizes the human gastric mucus layer. Recently, considerable studies changed the paradigm that H. pylori only participates in the pathogenesis of chronic gastritis and peptic ulcer disease, and demonstrated that several extra-intestinal diseases, such as renal-related diseases, were also caused by H. pylori [6][7][8]. The systemic antibody response to H. pylori was reported to be increased in patients with IgAN [9], suggesting that H. pylori might be involved in the pathogenesis and progression of IgAN.…”