<p>MAGGIC Risk Model Predicts Adverse Events and Left Ventricular Remodeling in Non-Ischemic Dilated Cardiomyopathy</p>

Abstract

Purpose We aimed to study the Meta-analysis Global Group in Chronic Heart Failure (MAGGIC) risk model’s prognostic value and relationship with left ventricular remodeling in dilated cardiomyopathy. Patients and Methods Dilated cardiomyopathy patients were prospectively recruited and underwent clinical assessments. MAGGIC risk score was calculated. Patients were followed up for adverse events and echocardiography. Primary endpoints were all-cause mortality and first rehospitalization due to heart failure. Secondary endpoint was left ventricular remodeling defined as a decline in left ventricular ejection fraction >10% or an increase in left ventricular end-diastolic diameter >10%. Survival status was examined using Cox regression analysis. The model’s ability to discriminate adverse events and left ventricular remodeling was calculated using a receiver operating characteristics curve. Results In total, 114 patients were included (median follow-up time = 31 months). The risk score was independently related to adverse events (2-year all-cause mortality: hazard ratio [HR] = 1.122; 95% confidence interval [CI], 1.043–1.208; 1-year first rehospitalization due to heart failure: HR = 1.094; 95% CI, 1.032–1.158; 2-year first rehospitalization due to heart failure: HR = 1.088; 95% CI, 1.033–1.147, all P < 0.05). One-year change in left ventricular end-diastolic diameter was correlated with the risk score (r = 0.305, P = 0.002). The model demonstrated modest ability in discriminating adverse events and left ventricular remodeling (all areas under the curve were 0.6–0.7). Conclusion The MAGGIC risk score was related to adverse events and left ventricular remodeling in dilated cardiomyopathy.

Progressive Left Ventricular Remodeling for Predicting Mortality in Children With Dilated Cardiomyopathy: The Pediatric Cardiomyopathy Registry

“…Although these have fair discriminant value, it is worth noting that no risk score has yet been deployed that leverages the degree of progressive or reverse remodeling that is accruing over time as a risk modifier. 13 , 14 …”

Prognostic effect of systematic geriatric assessment on patients with acute heart failure

“…It evaluates age, ejection fraction, systolic blood pressure, body mass index, creatinine, New York Heart Association class, gender, current smoker, presence of diabetes, chronic obstructive pulmonary disease, HF diagnosed more than 18 months ago, and treatment with BB and ACE‐I 23 . The MAGGIC risk score has been validated by several studies as a good risk tool for predicting the prognosis of HF patients, and also, it is related to left ventricular remodelling 24 …”

“… 23 The MAGGIC risk score has been validated by several studies as a good risk tool for predicting the prognosis of HF patients, and also, it is related to left ventricular remodelling. 24 …”

Transient Left Ventricular Dysfunction from Cardiomyopathies to Myocardial Viability: When and Why Cardiac Function Recovers

“…Cistatin C is a marker of renal function and it could be involved in collagen metabolism and heart remodeling, while HDL-C could act as an antioxidant factor [180]. Low BNP and galectin [182] levels at baseline are associated with LVRR [183,184]. Furthermore, two markers of DNA damage, Poly(ADP-ribose) and γ-H2A staining, have been proposed as good LVRR predictors [185].…”