<p>Magnesemia: an independent risk factor of hypocalcemia after thyroidectomy</p>

Abstract

Background This study was designed to investigate the impact of serum magnesium (Mg) levels on hypocalcemia after thyroidectomy. Patients and methods In total, 242 patients with differentiated thyroid cancer were retrospectively analyzed. Results Multivariate regression analysis showed hypomagnesemia was an independent risk factor for hypocalcemia ( P <0.001). While Mg in low levels (0.66 mmol/L ≤ Po-Mg ≤0.74 mmol/L) increased the risk of hypocalcemia, postoperative serum Ca (Po-Ca) levels were significantly lower in patients with hypomagnesemia than in patients with normomagnesemia ( P =0.01), and the former patients suffered significant decreases in serum Ca ( P =0.02). Compared to patients with a mild decline of serum Mg after surgery (ΔMg <0.17), serum Ca decline significantly increased ( P <0.001) in patients with a severe decline of serum Mg (ΔMg ≥0.17), while the change in amounts of parathyroid hormone (PTH) after surgery was similar between the two groups ( P >0.05). In patients with normal Po-Ca levels, hypomagnesemia increased the risk of symptoms related to hypocalcemia by 4.478 times (OR =5.478, 95% CI 1.724–17.403). Conclusion Hypomagnesemia, or even a low serum Mg level within the normal range, can increase the risk of hypocalcemia. After excluding the potential effects of PTH on serum magnesium and calcium, serum Mg reduction is one of the most important factors that influences postoperative serum Ca reduction. What’s more, hypomagnesemia is closely linked with symptoms.

Influencing factors and predictors of short-term normal parathyroid function after thyroidectomy: a case control study

“…Hypocalcemia often occurs after hypoparathyroidism. Some scholars have reported that the magnesium concentration after thyroid surgery is closely related to hypoparathyroidism [25][26][27][28]. We also nd that Pod7 Mg and Pod7 P are effective predictors of the return of PTH to normal levels on Pod7.…”

Risk factors for postoperative hypocalcaemia after thyroidectomy: A systematic review and meta-analysis

“…3,9,10,[15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34] The quality of all included studies was assessed using the NOS, of which 10 studies were rated as high quality (four with 8 stars and six with 7 stars) and 13 studies were rated as moderate quality (11 with 6 stars and two with 5 stars) (Table 1). 3,9,10,[15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34] According to the heterogeneity for the meta-analyses on preoperative vitamin D levels (I 2 ¼ 74%, P ¼ 0.010), preoperative PTH (I 2 ¼ 92%, P < 0.0001) and preoperative calcium levels (I 2 ¼ 79%, P < 0.0009), a random-effects model was used for the meta-analyses. According to the heterogeneity for the meta-...…”

Persistent Hypocalcemia after Thyroidectomy Stabilized with Magnesium

“…Some authors emphasize the importance of postoperative measurement of PTH and the fact that a decrease in their levels can predict the development of hypocalcemia due to thyroidectomy (19). When symptoms occur after thyroidectomy, both calcium and magnesium should be corrected and monitored (20). Thus, the measurement of calcium, magnesium, PTH and thyroid hormones is proposed in patients with risk factors who will undergo surgery.…”