<p>Meta-analysis of the prognostic value of C-C chemokine receptor type 7 in patients with solid tumors</p>

Abstract

Background Expression of C-C chemokine receptor type 7 (CCR7) is associated with the prognosis of several cancers. The aim of this study was to conduct the meta-analysis to determine the prognostic value of CCR7 expression in solid tumors. Materials and methods We searched for relevant literature in the PubMed, Embase, and Cochrane Library databases (last updated on January 15, 2018). The associations of CCR7 expression with overall survival (OS), disease-free survival (DFS), recurrence-free survival (RFS), progress-free survival (PFS), and disease-specific survival (DSS) were estimated. Results In total, 30 qualified studies including 3,413 patients were enrolled. The results revealed that higher expression of CCR7 predicted poorer OS (pooled HR =1.79; 95% CI =1.49–2.16; P <0.001) and PFS (pooled HR =2.18; 95% CI =1.49–3.18; P <0.001), but was not associated with DFS (pooled HR =1.69; 95% CI =0.79–3.61; P =0.175), RFS (pooled HR =1.29; 95% CI =0.48–3.44; P =0.618), or DSS (pooled HR =3.06; 95% CI =0.38–24.83; P <0.294). Conclusion From this meta-analysis, we concluded that high expression of CCR7 in tumor tissue is associated with poor survival in patients with solid tumors, and may be a prognostic biomarker for tumor progression.

Chemokines and their Receptors: Multifaceted Roles in Cancer Progression and Potential Value as Cancer Prognostic Markers

“…CCR7 has also been found to induce EMT in PDAC and lung cancer (LC) [174,175], promote MMP-2 and -9 expression in bladder cancer [176], and facilitate tumor cell dissemination, migration, and eventually metastasis formation [177]. With the strong protumor functions, the expression of CCR7 or CCL21 has been reported to be strongly correlated with poor survival [169,178]. Hence, CCR7 could become a predictive marker for a number of cancers, including colorectal liver metastasis.…”

CCR7 as a therapeutic target in Cancer

“…As described above, aberrant expression of CCR7 is observed in several cancers and this expression often corelates with poor prognosis. A meta-analysis of published literature up to January 2018 has shown that higher expression of CCR7 correlates with poorer overall survival (OS) and progression-free survival (PFS), although it did not show any correlation with disease-free survival (DFS), and recurrence-free survival (RFS) [208]. This is of course not surprising since CCR7 expression correlates with LN metastasis which in itself is an indicator of poor prognosis.…”

CCR7 Mediates Cell Invasion and Migration in Extrahepatic Cholangiocarcinoma by Inducing Epithelial–Mesenchymal Transition

“…First, in this retrospective study, samples were collected from a single Japanese center. Notably, a meta-analysis reported that the impact of high CCR7 expression on poor OS was more significant in Asian patients than that in Caucasians [ 38 ]. Therefore, a larger and more diverse sample must be analyzed to eliminate the risk of bias and validate the conclusions of this study.…”