&lt;p&gt;Minoxidil and Its Use in Hair Disorders: A Review [Corrigendum]&lt;/p&gt;

Suchonwanit, Poonkiat; Thammarucha, Sasima; Leerunyakul, Kanchana

doi:10.2147/dddt.s247601

Cited by 29 publications

(44 citation statements)

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“…It was first used as treatment of severe recalcitrant hypertension in the 1970s. 1 The therapy is associated with significant side-effects, including peripheral oedema, congestive heart failure and pulmonary oedema, as well as hypertrichosis. 2 After discovering this adverse effect, topical formulations were tested, demonstrating success in non-scarring alopecias.…”

Section: Introductionmentioning

confidence: 99%

“…3 Also, it opens potassium channels located in smooth muscles of peripheral arteries, shortening the telogen phase and prolonging the anagen phase, 6 with a progressive growth in diameter and length of hair follicles. 1,5 Minoxidil also moderates concanavalin A, an intermediary in the activation process of T lymphocytes, having an immunomodulatory effect, with possible positive outcomes in autoimmune alopecias. 3 It is a prodrug that requires conversion by the sulfotransferase enzymes to minoxidil sulphate to be biologically active.…”

Section: Introductionmentioning

confidence: 99%

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Review of oral minoxidil as treatment of hair disorders: in search of the perfect dose

Villani

Fabbrocini

Candiani³

et al. 2021

Acad Dermatol Venereol

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Topical minoxidil has been used for many years as treatment for different hair disorders. Even though it is an effective therapy, many patients show poor compliance due to the cosmesis, cost and side‐effects. During the last few years, low‐dose oral minoxidil has proven to be an alternative for patients with alopecia. We performed a literature search including all the articles that used oral minoxidil as a primary treatment in various hair diseases in order to evaluate the efficacy and safety of low‐dose oral minoxidil as an alternative to topical minoxidil. Androgenetic alopecia was the most common studied condition, but others included telogen effluvium, tractional alopecia, postchemotherapy‐induced alopecia, monilethrix, loose anagen hair syndrome, alopecia areata and scarring alopecias (frontal fibrosing alopecia and lichen planopilaris). Larger randomized comparative studies including standardized objective measurements should be done in order to clarify the best treatment protocol, including dosage and treatment duration. Oral minoxidil has proven to be a successful and well‐tolerated alternative for patients with hair loss, including those with poor adherence to other therapies. Different dosing regimens have been utilized in scarring and non‐scarring alopecia, varying from 0.25 to 5 mg daily. Higher doses have not been studied in men or women. Available literature suggests women require lower doses, from 0.25 to 2.5 mg daily, while men require higher doses for maximal efficacy, from 1.25 to 5 mg a day.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Review of oral minoxidil as treatment of hair disorders: in search of the perfect dose

Villani

Fabbrocini

Candiani³

et al. 2021

Acad Dermatol Venereol

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“…Therapeutic results are observed up to 6 months into the treatment. Its efficacy has been proven, and the drug has a good safety profile, with minimum side effects [ 6 , 11 , 12 ]. Minoxidil improves blood flow through the scalp [ 13 ], and activates potassium channels, which stimulates the transition of hair follicles from the telogen phase to the anagen phase [ 14 ].…”

Section: Discussionmentioning

confidence: 99%

Scalp vascularization as a marker of topical minoxidil treatment efficacy in patients with androgenetic alopecia

Kozicka¹,

Łukasik²,

Pastuszczak³

et al. 2022

pdia

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Introduction Androgenetic alopecia is the most common type of non-cicatricial hair loss both in male and female patients. The pathomechanism of the disease involves chronic and progressive miniaturization of hair follicles, which leads to the conversion of terminal hair to vellus hair. Minoxidil is a first-line drug in the treatment of female pattern hair loss (FPHL). Aim The study is aimed at verifying whether the degree of scalp vascularization has an impact on the efficacy of topical 5% minoxidil treatment. Material and methods The study involved a group of 76 patients diagnosed with FPHL, who underwent a scalp biopsy for a histological examination of their scalp vascularization. The patients were divided into two groups, with rich and poor scalp vasculature. In all patients, topical treatment with 5% minoxidil was applied for a minimum of 6 months, followed by video-trichoscopic assessment. Results A significant increase in the total count was observed 6 months into the treatment as compared with baseline, and a decrease in the number of single hair per follicle. It was observed that the number of single hair units had gone down in 50.67% of patients. The study also demonstrated an increase in the total hair count in 57.33% of patients as well as no drops in the total count in 68% of patients, following 6 months of treatment. Conclusions Patients responded equally well to the applied topical minoxidil treatment, irrespectively of the number of blood vessels in the scalp.

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“…Patients may exhibit side effects with topical minoxidil use which include irritant and allergic contact dermatitis, pruritus, scalp irritation, and facial hypertrichosis, which are more often seen with use of 5% solutions rather than 2% 32 . Overall, the incidence of side effects with minoxidil use is fairly low and non‐serious 33 …”

Section: Topical Therapiesmentioning

confidence: 99%

Treatment options for androgenetic alopecia: Efficacy, side effects, compliance, financial considerations, and ethics

Nestor

Ablon

Gade

et al. 2021

J of Cosmetic Dermatology

179

105

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<p>Minoxidil and Its Use in Hair Disorders: A Review [Corrigendum]</p>

Cited by 29 publications

References 0 publications

Review of oral minoxidil as treatment of hair disorders: in search of the perfect dose

Review of oral minoxidil as treatment of hair disorders: in search of the perfect dose

Scalp vascularization as a marker of topical minoxidil treatment efficacy in patients with androgenetic alopecia

Treatment options for androgenetic alopecia: Efficacy, side effects, compliance, financial considerations, and ethics

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