&lt;p&gt;MiR-519d and miR-328-3p Combinatorially Suppress Breast Cancer Progression&lt;/p&gt;

Ma, Haiming; Liu, Tao; Xu, Yihuan; Wang, Xinying; Wang, Jin; Liu, Xiaokang

doi:10.2147/ott.s281962

Cited by 11 publications

(4 citation statements)

References 23 publications

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“…In addition, the miR-328 decreased chemoresistance by targeting several genes involved in the ABC transporter, such as ABCG2 also known as breast cancer resistance protein BCRP, ABCD3 [ 61 , 62 ]. Suggested as a novel biomarker for the diagnosis and as a promising strategy for therapeutic manipulation, miR-328-3p combined with miR-519d suppressed breast cancer progression by targeting Ki67 [ 63 ]. Reported as a potential non-invasive poor prognosis biomarker for AML patients, deeper investigation of the main functions of the miR-328-3p in the AML stem cell chemoresistance capacity, which combined with another miRNA, might downregulate common target genes, which code survival signaling proteins, could eventually be a promising strategy to overcome AML relapse.…”

Section: Discussionmentioning

confidence: 99%

Blockade of p38 MAPK overcomes AML stem cell line KG1a resistance to 5-Fluorouridine and the impact on miRNA profiling

et al. 2022

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Most of the AML patients in remission develop multidrug resistance after the first-line therapy and relapse. AML stem cells have gained attention for their chemoresistance potentials. Chemoresistance is a multifactorial process resulting from altered survival signaling pathways and apoptosis regulators such as MAPK, NF-κB activation and ROS production. We targeted the survival pathway p38 MAPK, NF-κB and ROS generation in human chemoresistant AML stem cell line KG1a, susceptible to enhance cell sensitivity to the chemotherapy drug 5-Fluorouridine, compared to the chemosensitive AML cell line HL60. After confirming the phenotypic characterization of KG1a and HL60 cells using flow cytometry and transcriptomic array analyses, cell treatment with the NF-κB inhibitor IKKVII resulted in a complete induction of apoptosis, and a few p38 MAPK inhibitor SB202190-treated cells underwent apoptosis. No change in the apoptosis status was observed in the ROS scavenger N-acetylcysteine-treated cells. The p38 MAPK pathway blockade enhanced the KG1a cell sensitivity to 5-Fluorouridine, which was associated with the upregulation of microribonucleic acid-(miR-)328-3p, as determined by the microarray-based miRNA transcriptomic analysis. The downregulation of the miR-210-5p in SB202190-treated KG1a cells exposed to FUrd was monitored using RT-qPCR. The miR-328-3p is known for the enhancement of cancer cell chemosensitivity and apoptosis induction, and the downregulation of miR-210-5p is found in AML patients in complete remission. In conclusion, we highlighted the key role of the p38 MAPK survival pathway in the chemoresistance capacity of the AML stem cells and potentially involved miRNAs, which may pave the way for the development of a new therapeutic strategy targeting survival signaling proteins and reduce the rate of AML relapse.

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Section: Discussionmentioning

confidence: 99%

Blockade of p38 MAPK overcomes AML stem cell line KG1a resistance to 5-Fluorouridine and the impact on miRNA profiling

et al. 2022

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“…In the last decade, it has been indicated that microRNAs (miRNAs) are downregulated in many types of cancers (13,14). This study is the initial attempt to explore the potential link between miR-143 gene polymorphisms (rs4705342) and oral squamous cell carcinoma (OSCC) susceptibility in an Iranian community.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Association of mir-143 and rs4705342 single nucleotide polymorphism with Oral Squamous cell carcinoma

Rezazadeh

Ranjbar

et al. 2023

Preprint

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Introduction Numerous studies have demonstrated that decreased expression of miR-143 is frequently observed in different cancer types, which can lead to an elevated probability of cell proliferation, migration, apoptosis, invasion, and epithelial to mesenchymal transition. Among, all head and neck cancers, oral squamous cell carcinoma (OSCC) is the most commonly occurring type. Thus, the aim of this research is to explore the possibility of scrutinizing the plausibility correlation between a functional polymorphism (i.e., rs4705342) located in the flanking region of miR-143 and the susceptibility of Iranian individuals to squamous cell carcinoma. Methods we recruited a total of 245 participants in this cross-sectional study, consisting of 95 patients diagnosed with OSCC and 150 healthy controls. The tetra-primer ARMS-PCR method was used to genotype the rs4705342 polymorphism. This method is a highly accurate and validated technique for detecting genetic variations. The genotyping results were further validated through DNA sequencing to ensure accuracy and minimize errors. Results Our analysis of the allele and genotype frequencies of the miR-143 rs4705342 polymorphism revealed significant differences between OSCC cases and controls. Using the chi-square test, we found that the P-value was less than 0.05, which indicates that the null hypothesis of no significant difference in gene expression between the two groups can be rejected. Therefore, our findings imply that the rs4705342 polymorphism might be linked with a higher susceptibility to OSCC in the Iranian population. Conclusion We have discovered evidence that supports the notion that the presence of the miR-143 rs4705342 polymorphism may be a contributing factor in the development of OSCC in the Iranian population. However, further studies, sample sizes and diverse populations are needed to better evaluate the significance of this genetic variation in OSCC pathogenesis. Overall, our findings emphasize the importance of identifying genetic factors that may influence cancer risk and the need for continued research to improve the prevention and treatment of this disease.

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“…Recently, a study reported that inhibition of miR-328-3p impairs ovarian CSCs function, a finding that is inconsistent with our results [ 33 ]. For this reason, we examined relevant literature and found that miR-328-3p has different roles in different human cancers [ 8 – 10 , 12 , 32 , 33 ], indicating that the function of miR-328-3p could be tissue and tumor specific.…”

Section: Discussionmentioning

confidence: 99%

“…Researchers have found that miR-328-3p can downregulate ABCG2 in some BC cell lines, and plays a role in drug resistance [ 11 ]. However, other reports have indicated that miR-328-3p can counteract the BC malignant phenotype [ 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Fatty acid β-oxidation promotes breast cancer stemness and metastasis via the miRNA-328-3p-CPT1A pathway

et al. 2021

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MicroRNAs (miRNA) have been shown to be associated with tumor diagnosis, prognosis, and therapeutic response. MiR-328-3p plays a significant role in breast cancer growth; however, its actual function and how it modulates specific biological functions is poorly understood. Here, miR-328-3p was significantly downregulated in breast cancer, especially in patients with metastasis. Mitochondrial carnitine palmitoyl transferase 1a (CPT1A) is a downstream target gene in the miR-328-3p-regulated pathway. Furthermore, the miR-328-3p/CPT1A/fatty acid β-oxidation/stemness axis was shown responsible for breast cancer metastasis. Collectively, this study revealed that miR-328-3p is a potential therapeutic target for the treatment of breast cancer patients with metastasis, and also a model for the miRNA-fatty acid β-oxidation-stemness axis, which may assist inunderstanding the cancer stem cell signaling functions of miRNA.

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<p>MiR-519d and miR-328-3p Combinatorially Suppress Breast Cancer Progression</p>

Cited by 11 publications

References 23 publications

Blockade of p38 MAPK overcomes AML stem cell line KG1a resistance to 5-Fluorouridine and the impact on miRNA profiling

Blockade of p38 MAPK overcomes AML stem cell line KG1a resistance to 5-Fluorouridine and the impact on miRNA profiling

Evaluation of the Association of mir-143 and rs4705342 single nucleotide polymorphism with Oral Squamous cell carcinoma

Fatty acid β-oxidation promotes breast cancer stemness and metastasis via the miRNA-328-3p-CPT1A pathway

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