&lt;p&gt;Modulation of Chronic Inflammation by Quercetin: The Beneficial Effects on Obesity&lt;/p&gt;

Sato, Shin; Mukai, Yuuka

doi:10.2147/jir.s228361

Cited by 93 publications

(60 citation statements)

References 116 publications

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“…In fact, the increasing incidence of obesity and corresponding rise in type-2 diabetes are further challenging the prevention and treatment of CVD (253). The metabolic effects of quercetin against these two conditions have been equally encouraging and were recently reviewed elsewhere (254)(255)(256)(257)(258). In addition, it should be emphasized that, for clarity reasons, the effects of quercetin on the various biochemical and biomechanical signaling cascades involved in endothelial dysfunction were discussed as separate entities.…”

Section: Discussionmentioning

confidence: 99%

Therapeutic Potential of Quercetin to Alleviate Endothelial Dysfunction in Age-Related Cardiovascular Diseases

Dagher

Mury

Thorin‐Trescases

et al. 2021

Front. Cardiovasc. Med.

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The vascular endothelium occupies a catalog of functions that contribute to the homeostasis of the cardiovascular system. It is a physically active barrier between circulating blood and tissue, a regulator of the vascular tone, a biochemical processor and a modulator of coagulation, inflammation, and immunity. Given these essential roles, it comes to no surprise that endothelial dysfunction is prodromal to chronic age-related diseases of the heart and arteries, globally termed cardiovascular diseases (CVD). An example would be ischemic heart disease (IHD), which is the main cause of death from CVD. We have made phenomenal advances in treating CVD, but the aging endothelium, as it senesces, always seems to out-run the benefits of medical and surgical therapies. Remarkably, many epidemiological studies have detected a correlation between a flavonoid-rich diet and a lower incidence of mortality from CVD. Quercetin, a member of the flavonoid class, is a natural compound ubiquitously found in various food sources such as fruits, vegetables, seeds, nuts, and wine. It has been reported to have a wide range of health promoting effects and has gained significant attention over the years. A growing body of evidence suggests quercetin could lower the risk of IHD by mitigating endothelial dysfunction and its risk factors, such as hypertension, atherosclerosis, accumulation of senescent endothelial cells, and endothelial-mesenchymal transition (EndoMT). In this review, we will explore these pathophysiological cascades and their interrelation with endothelial dysfunction. We will then present the scientific evidence to quercetin's anti-atherosclerotic, anti-hypertensive, senolytic, and anti-EndoMT effects. Finally, we will discuss the prospect for its clinical use in alleviating myocardial ischemic injuries in IHD.

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Section: Discussionmentioning

confidence: 99%

Therapeutic Potential of Quercetin to Alleviate Endothelial Dysfunction in Age-Related Cardiovascular Diseases

Dagher

Mury

Thorin‐Trescases

et al. 2021

Front. Cardiovasc. Med.

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“…It has been mentioned in studies that quercetin has antioxidant, anti-inflammatory, antiviral, anti-obesity, antidepressant properties, as well as preventing cancer, diabetes, asthma, hypertension, and cardiovascular diseases [ 135 , 136 ]. A study reported by Ju et al [ 137 ] stated that quercetin decreases the abundance of E. coli and proteobacteria.…”

Section: Quercetinmentioning

confidence: 99%

Curcumin, Quercetin, Catechins and Metabolic Diseases: The Role of Gut Microbiota

et al. 2021

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Polyphenols (PPs) are the naturally occurring bioactive components in fruits and vegetables, and they are the most abundant antioxidant in the human diet. Studies are suggesting that ingestion of PPs might be helpful to ameliorate metabolic syndromes that may contribute in the prevention of several chronic disorders like diabetes, obesity, hypertension, and colon cancer. PPs have structural diversity which impacts their bioavailability as they accumulate in the large intestine and are extensively metabolized through gut microbiota (GM). Intestinal microbiota transforms PPs into their metabolites to make them bioactive. Interestingly, not only GM act on PPs to metabolize them but PPs also modulate the composition of GM. Thus, change in GM from pathogenic to beneficial ones may be helpful to ameliorate gut health and associated diseases. However, to overcome the low bioavailability of PPs, various approaches have been developed to improve their solubility and transportation through the gut. In this review, we present evidence supporting the structural changes that occur after metabolic reactions in PPs (curcumin, quercetin, and catechins) and their effect on GM composition that leads to improving overall gut health and helping to ameliorate metabolic disorders.

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“…An in vivo study conducted on 60 subjects showed a statistically significant reduction in IL-6 and C-reactive protein (CRP), after a supplementation of 500 mg/day of quercetin for 8 weeks [ 267 ]. Furthermore, quercetin seems to be able to reduce COX-2 [ 268 ] and inducible nitric oxide synthase (iNOS) gene expression [ 269 , 282 ]. Quercetin can improve the body’s antioxidant defenses by stimulating the synthesis of glutathione (GSH) and modulating the expression of catalase, GSH peroxidase and superoxide dismutase (SOD) [ 281 ].…”

Section: Possible Effects Of Natural Bioactive Compounds In Metabomentioning

confidence: 99%

Natural Bioactive Compounds Useful in Clinical Management of Metabolic Syndrome

et al. 2021

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Metabolic syndrome (MetS) is a clinical manifestation characterized by a plethora of comorbidities, including hyperglycemia, abdominal obesity, arterial hypertension, and dyslipidemia. All MetS comorbidities participate to induce a low-grade inflammation state and oxidative stress, typical of this syndrome. MetS is related to an increased risk of cardiovascular diseases and early death, with an important impact on health-care costs. For its clinic management a poly-pharmaceutical therapy is often required, but this can cause side effects and reduce the patient’s compliance. For this reason, finding a valid and alternative therapeutic strategy, natural and free of side effects, could represent a useful tool in the fight the MetS. In this context, the use of functional foods, and the assumption of natural bioactive compounds (NBCs), could exert beneficial effects on body weight, blood pressure and glucose metabolism control, on endothelial damage, on the improvement of lipid profile, on the inflammatory state, and on oxidative stress. This review focuses on the possible beneficial role of NBCs in the prevention and in the clinical management of MetS and its comorbidities.

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<p>Modulation of Chronic Inflammation by Quercetin: The Beneficial Effects on Obesity</p>

Cited by 93 publications

References 116 publications

Therapeutic Potential of Quercetin to Alleviate Endothelial Dysfunction in Age-Related Cardiovascular Diseases

Therapeutic Potential of Quercetin to Alleviate Endothelial Dysfunction in Age-Related Cardiovascular Diseases

Curcumin, Quercetin, Catechins and Metabolic Diseases: The Role of Gut Microbiota

Natural Bioactive Compounds Useful in Clinical Management of Metabolic Syndrome

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