Diabetic foot ulcers: treatment overview and cost considerations D iabetic foot ulcers (DFUs) are deep tissue lesions associated with ischaemic, neuropathic, or combined neuroischaemic abnormalities and are a leading cause of morbidity and mortality. 1,2 Of concern is that DFUs affect multiple areas of a person's functioning, including both physical and psychological distress. 3,4 For example, inactivity due to a DFU can cause feelings of frustration, anger and guilt in patients. 5,6 This distress has the potential to impair the immune response as well as impacting the quality of life (QoL). [7][8][9] DFUs are often complicated by the presence of infection and this combined with abnormalities are a key cause of amputation in patients with DM, indeed up to 85% of lower extremity amputations are preceded by the presence of a DFU. 10 Furthermore, even when treatment plans are followed, not all DFUs heal, and those that do have a high rate of recurrence. 11,12 Numerous epidemiological studies on DFUs have reported an elevation in the incidence of DFUs due to a greater life expectancy in patients with diabetes and an increasing worldwide prevalence of diabetes within an ageing population. 10,[13][14][15] DFUs are estimated to occur in one in every seven patients with diabetes. [16][17][18] Furthermore, a recent systematic review showed the global prevalence of DFUs at 6.3% (95% confidence interval (CI): 5.4-7.3%), with the