<p>Nano Encapsulated Curcumin: And Its Potential for Biomedical Applications</p>

Abstract

Curcumin, a yellow-colored polyphenol extracted from the rhizome of turmeric root, is commonly used as a spice and nutritional supplement. It exhibits many pharmacological activities such as anti-inflammatory, anti-bacterial, anti-cancer, anti-Alzheimer, and anti-fungal. However, the therapeutic application of curcumin is limited by its extremely low solubility in aqueous buffer, instability in body fluids, and rapid metabolism. Nano delivery system has shown excellent potential to improve the solubility, biocompatibility and therapeutic effect of curcumin. In this review, we focus on the recent development of nano encapsulated curcumin and its potential for biomedical applications.

Plant-Derived Natural Products in Cancer Research: Extraction, Mechanism of Action, and Drug Formulation

“…Table 2 summarizes the commercially approved target delivery systems and their active natural products. Improve health life quality, anti-inflammatory effect in patients with solid tumors [701] ALL = acute lymphoblastic leukemia.…”

Effects of Curcumin on High Glucose-Induced Epithelial-to-Mesenchymal Transition in Renal Tubular Epithelial Cells Through the TLR4-NF-κB Signaling Pathway

“…With the researches of Curcumin nanoformulations may address the limitation of low bioavailability and provides a promising therapeutic strategy, there is the potential of Curcumin being a therapeutic agent to suppress renal fibrosis and delay the development of DN. 26 Previously, we have reported that Curcumin plays an important role in cellular antioxidant defense via the activation of Nrf2 and HO-1, thereby protecting HG-induced EMT in the NRK-52E cells. 27 However, whether Curcumin has anti-fibrosis effects in DKD, especially in TLR4-NF-κB during EMT of kidney tubular epithelial cell is still unknown.…”

Curcumin Loaded Nanoliposomes Localization by Nanoscale Characterization

“…For centuries, crude curcumin, a traditional Asian medicine, was used as a food spice and dietary supplement [ 3 , 4 ]. Curcumin or its family, curcuminoids, exhibits many potential benefits and pharmacological activities such as anti-cancer, anti-Alzheimer, antifungal, antibacterial, antioxidant, and anti-inflammatory agents [ 5 , 6 , 7 ]. Curcumin is Generally Recognized as Safe (GRAS) by the FDA, which strengthens its case as a potential natural drug [ 8 ].…”