&lt;p&gt;Nanoparticle Drug Delivery Systems for α-Mangostin&lt;/p&gt;

Wathoni, Nasrul; Rusdin, Agus; Motoyama, Keiichi; Joni, I Made; Lesmana, Ronny; Muchtaridi, Muchtaridi

doi:10.2147/nsa.s243017

Cited by 57 publications

(44 citation statements)

References 104 publications

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“…The formulation of NPs affects their biopharmaceutical, pharmacokinetic, and pharmacodynamic aspects. In addition, polymeric NPs provide targeted delivery and significantly enhance AMG biodistribution to specific organs [ 105 ].…”

Section: Nanotechnology Of Amg In Breast Cancermentioning

confidence: 99%

“…Bonafe et al demonstrated that AMG loaded in CD44 Thioaptamer-tagged NPs reduces the number of BC cancer cells [ 7 ]. NPs that mediate passive or active target delivery are generally prepared with a high affinity for the target and low affinity for normal cells [ 105 ].…”

Section: Nanotechnology Of Amg In Breast Cancermentioning

confidence: 99%

“…The possibility of endothelial leakage caused by nanomaterials must be considered while developing future nanomedicines, particularly those used to treat cancer [ 114 ]. The delivery of AMG with can be achieved with a nanoparticle system, in accordance with improvements in pharmacokinetic properties, drug release, and drug targeting [ 105 ].…”

Section: Nanotechnology Of Amg In Breast Cancermentioning

confidence: 99%

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α-Mangostin Nanoparticles Cytotoxicity and Cell Death Modalities in Breast Cancer Cell Lines

et al. 2021

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α-Mangostin (AMG) is a potent anticancer xanthone that was discovered in mangosteen (Garcinia mangostana Linn.). AMG possesses the highest opportunity for chemopreventive and chemotherapeutic therapy. AMG inhibits every step in the process of carcinogenesis. AMG suppressed multiple breast cancer (BC) cell proliferation and apoptosis by decreasing the creation of cancerous compounds. Accumulating BC abnormalities and their associated molecular signaling pathways promotes novel treatment strategies. Chemotherapy is a commonly used treatment; due to the possibility of unpleasant side effects and multidrug resistance, there has been substantial progress in searching for alternative solutions, including the use of plant-derived natural chemicals. Due to the limitations of conventional cancer therapy, nanotechnology provides hope for effective and efficient cancer diagnosis and treatment. Nanotechnology enables the delivery of nanoparticles and increased solubility of drugs and drug targeting, resulting in increased cytotoxicity and cell death during BC treatment. This review summarizes the progress and development of AMG’s cytotoxicity and the mechanism of death BC cells. The combination of natural medicine and nanotechnology into a synergistic capital will provide various benefits. This information will aid in the development of AMG nanoparticle preparations and may open up new avenues for discovering an effective BC treatment.

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Section: Nanotechnology Of Amg In Breast Cancermentioning

confidence: 99%

Section: Nanotechnology Of Amg In Breast Cancermentioning

confidence: 99%

Section: Nanotechnology Of Amg In Breast Cancermentioning

confidence: 99%

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α-Mangostin Nanoparticles Cytotoxicity and Cell Death Modalities in Breast Cancer Cell Lines

et al. 2021

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“…Biocompatibility is one of the most important criteria in biomaterials selection. ChNPs can be administered orally and intravenously into host cells [ 21 ]. ChNPs are used as a drug delivery system targeted at cancer therapy [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Chitosan-Based Nanoparticles of Targeted Drug Delivery System in Breast Cancer Treatment

et al. 2021

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Breast cancer remains one of the world’s most dangerous diseases because of the difficulty of finding cost-effective and specific targets for effective and efficient treatment methods. The biodegradability and biocompatibility properties of chitosan-based nanoparticles (ChNPs) have good prospects for targeted drug delivery systems. ChNPs can transfer various antitumor drugs to targeted sites via passive and active targeting pathways. The modification of ChNPs has attracted the researcher to the loading of drugs to targeted cancer cells. The objective of our review was to summarize and discuss the modification in ChNPs in delivering anticancer drugs against breast cancer cells from published papers recorded in Scopus, PubMed, and Google Scholar. In order to improve cellular uptake, drug accumulation, cytotoxicity, and selectivity, we examined different kinds of modification of ChNPs. Notably, these forms of ChNPs use the characteristics of the enhanced permeability and retention (EPR) effect as a proper parameter and different biological ligands, such as proteins, peptides, monoclonal antibodies, and small particles. In addition, as a targeted delivery system, ChNPs provided and significantly improved the delivery of drugs into specific breast cancer cells (MDA-MB-231, 4T1 cells, SK-BR-3, MCF-7, T47D). In conclusion, a promising technique is presented for increasing the efficacy, selectivity, and effectiveness of candidate drug carriers in the treatment of breast cancer.

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“…Many drugs and bioactive substances have some inconveniences in use; therefore, nanoparticle delivery systems were developed to improve the bioavailability and effectiveness of these substances (Wathoni et al 2020). Nanostructured lipid carriers (NLC) are lipid nanoparticles composed of a solid lipid matrix incorporated with liquid lipid or oil (E Eleraky et al 2020).…”

Section: Introductionmentioning

confidence: 99%

Nanostructure Lipid Carriers Enhance Alpha-Mangostin Neuroprotective Efficacy In Mice With Rotenone-Induced Neurodegeneration

Sakamula

Yata

Thong-asa³

2021

Preprint

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Neurodegenerative disease, for instance, Parkinson’s disease (PD), is associated with substantia nigra dopaminergic neuronal loss with subsequent striatal dopamine reduction, leading to motor deficits. Currently, there is no available effective therapy for PD; thus, novel therapeutic agents such as natural antioxidants with neuroprotective effects are emerging. Alpha-mangostin (αM) is a xanthone derivative compound from mangosteen peel with a cytoprotective effect depicted in neurodegenerative disease models. However, αM has low aqueous solubility and low biodistribution in the brain. Nanostructured lipid carriers (NLC) have been used to encapsulate bioactive compounds delivered to target organs to improve the oral bioavailability and effectiveness. This study aimed to investigate the effect of αM and αM encapsulated in NLC (αM-NLC) in mice with rotenone-induced PD-like neurodegeneration. Forty male ICR mice were divided into normal, PD, PD+αM, and PD+ αM-NLC groups. Vehicle, αM (25 mg/kg/48 h), and αM-NLC (25 mg/kg/48 h) were orally administered, along with PD induction by intraperitoneal injection of rotenone (2.5 mg/kg/48 h) for 4 consecutive weeks. Motor abilities were assessed once a week using rotarod and hanging wire tests. Biochemical analysis of brain oxidative status was conducted, and neuronal populations in substantia nigra par compacta (SNc), striatum, and motor cortex were evaluated using Nissl staining. Tyrosine hydroxylase (TH) immunostaining of SNc and striatum was also evaluated. Results showed that rotenone significantly induced motor deficits concurrent with significant SNc, striatum, and motor cortex neuronal reduction and significantly decreased TH intensity in SNc (p < 0.05). The significant reduction of brain superoxide dismutase activity (p < 0.05) was also detected. Administrations of αM and αM-NLC significantly reduced motor deficits, prevented the reduction of TH intensity in SNc and striatum, and prevented the reduction of neurons in SNc (p < 0.05). Only αM-NLC significantly prevented the reduction of neurons in both striatum and motor cortex (p < 0.05). These were found concurrent with significantly reduced malondialdehyde level and increased catalase and superoxide dismutase activities (p < 0.05). Therefore, this study depicted the neuroprotective effect of αM and αM-NLC against rotenone-induced PD-like neurodegeneration in mice. We indicated an involvement of NLC, emphasizing the protective effect of αM against oxidative stress. Moreover, αM-NLC exhibited broad protection against rotenone-induced neurodegeneration that was not limited to nigrostriatal structures and emphasized the benefit of NLC in enhancing αM neuroprotective effects.

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<p>Nanoparticle Drug Delivery Systems for α-Mangostin</p>

Cited by 57 publications

References 104 publications

α-Mangostin Nanoparticles Cytotoxicity and Cell Death Modalities in Breast Cancer Cell Lines

α-Mangostin Nanoparticles Cytotoxicity and Cell Death Modalities in Breast Cancer Cell Lines

Chitosan-Based Nanoparticles of Targeted Drug Delivery System in Breast Cancer Treatment

Nanostructure Lipid Carriers Enhance Alpha-Mangostin Neuroprotective Efficacy In Mice With Rotenone-Induced Neurodegeneration

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