&lt;p&gt;Nocturnal Mean Oxygen Saturation Is Associated with Secondary Polycythemia in Young Adults with Obstructive Sleep Apnea, Especially in Men&lt;/p&gt;

Li, Ning; Li, Hong Peng; Wang, Ping; Yan, Yingjie; Li, Shi Qi

doi:10.2147/nss.s226143

Cited by 21 publications

(18 citation statements)

References 39 publications

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“… 21 In another study, OSA was an independent predictor for polycythemia in patients receiving androgen supplementation. 22 Moreover, in the report by Li et al 10 OSA severity was related to the prevalence of polycythemia and mean SaO 2 was an independent predictor of polycythemia. We found that the presence of polycythemia was related to age, BMI, neck circumference, severe OSA, min SaO 2 , mean SaO 2 , ODI, and TS 90 in binary logistic regression analysis, and multivariate analysis showed that age and TS 90 were independent predictors after adjusting for other confounders.…”

Section: Discussionmentioning

confidence: 93%

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Obstructive Sleep Apnea is Associated with an Increased Prevalence of Polycythemia in Patients with Chronic Obstructive Pulmonary Disease

Zeng¹,

Yan²,

He³

et al. 2022

COPD

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Purpose Chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA) are associated with polycythemia. However, there still remain unanswered questions about the relationship between overlap syndrome (OVS), where OSA and COPD coexist, and polycythemia. Here, we aimed to establish the prevalence of polycythemia in OVS patients and to explore the impact of OSA on polycythemia. Patients and Methods Patients with COPD underwent overnight polysomnography (PSG), pulmonary function tests, echocardiography, and complete blood counts. All patients were ethnic Han Chinese and free of prolonged oral corticosteroid use, hematological system disease, severe systemic disease, and other sleep-disordered breathing. OVS was defined as COPD patients with an apnea–hypopnea index ≥15 events/h, and polycythemia was defined as an Hb >165 g/L in men and >160 g/L in women. Results Eight-hundred and eighty-six patients with COPD were included in the analysis. The prevalence of polycythemia was significantly higher in OVS patients than COPD-alone patients (6.4% vs 2.9%, p < 0.05). The prevalence of polycythemia increased with OSA severity ( χ 2 = 7.885, p = 0.007), but not in GOLD grade 3–4 COPD patients ( χ 2 = 0.190, p = 0.663). After adjusting for confounders, percentage of total sleep time with SaO 2 <90% (TS 90 ) remained independently associated with an increased odds of polycythemia (OR 1.030, 95% CI 1.015–1.046) and, with an increase in TS 90 , the hemoglobin increased, especially in GOLD grade 1–2 patients ( p < 0.05). Conclusion Patients with OVS have a higher prevalence of polycythemia than those with COPD alone, and TS 90 is an independent factor for polycythemia, especially in GOLD1-2 COPD patients.

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Section: Discussionmentioning

confidence: 93%

“… 7 , 8 OSA severity is significantly associated with hemoglobin (Hb) and RBC counts, 7 and the prevalence of polycythemia in OSA patients is reported to be between 1.6% and 10%. 9 , 10 Furthermore, RBC count and hemoglobin significantly decreased in OSA patients after continuous positive airway pressure (CPAP) therapy. 11 …”

Section: Introductionmentioning

confidence: 99%

Obstructive Sleep Apnea is Associated with an Increased Prevalence of Polycythemia in Patients with Chronic Obstructive Pulmonary Disease

Zeng¹,

Yan²,

He³

et al. 2022

COPD

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“…Although several studies have investigated the relationship between OSA and secondary erythrocytosis, the results are inconsistent and controversial. Some studies found a significantly increased hematocrit value in patients with OSA compared to that in the control group, [16][17][18][19][20][21] whereas others did not. 22,23 This discrepancy may be due to several factors, such as the statistical power of the study and differences in the composition of the study populations.…”

Section: Introductionmentioning

confidence: 95%

“…In addition, two articles from the reference lists of retrieved articles were assessed. Finally, 11 articles [16][17][18][19][20][21][22][23][30][31][32] with a total of 4608 patients with OSA and 1484 individuals without OSA were included in the meta-analysis. A flowchart of the study selection process is shown in Figure 1.…”

Section: Literature Search and Study Characteristicsmentioning

confidence: 99%

Is obstructive sleep apnea associated with erythrocytosis? A systematic review and meta‐analysis

Rha

Jeong

Kim

et al. 2022

Laryngoscope Investig Oto

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Objective The aim of this systematic review and meta‐analysis was to investigate the association between obstructive sleep apnea (OSA) and erythrocytosis. Methods The PubMed, Web of Science, and Cochrane Library databases were searched for articles examining hematocrit values in patients with OSA and control individuals published till September 1, 2021. The pooled standardized mean difference (SMD) with 95% confidence interval (CI) was calculated, and subgroup analyses were performed. Results Eleven eligible studies with a total of 4608 patients with OSA were included in this meta‐analysis. Pooled outcomes revealed that hematocrit values were significantly higher in patients with OSA than in controls (SMD, 0.19; 95% CI, 0.08–0.29; p < .01). When studies were stratified by disease severity, the significant differences in hematocrit values between patients and controls were only observed in the severe OSA group (SMD, 0.34; 95% CI, 0.08–0.59; p < .01), but not in the mild and moderate OSA groups. In subgroup analyses according to sex and publication year, significant differences in hematocrit values between patients and controls remained stable in studies with only female patients (SMD, 0.25; 95% CI, 0.12–0.38; p < .01) and in studies published after 2012 (SMD, 0.17; 95% CI, 0.06–0.28, p < .01). Conclusion Our meta‐analysis revealed that the hematocrit value was significantly increased in patients with OSA, particularly in severe patients, compared with that in controls. However, the elevation was modest, and the hematocrit value is expected to be within the normal range in patients with OSA. These data suggest that OSA leads to slight increases in hematocrit but does not cause clinically significant erythrocytosis.

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“…(2) direct benefits on renal function [140][141], preventing associated CAN from further self-sustaining kidney function impairment [76][77]86] ; (3) Ht increasing effects, expected to reduce nighttime hypoxia [189][190][191].…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Possible Preventative/Rehabilitative Role of Gliflozins in OSA and T2DM. A Systematic Literature Review-Based Hypothesis

Monda¹,

Porcellati

Strollo

et al. 2021

Adv Ther

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Obstructive sleep apnoea (OSA) is characterized by frequent apnoea episodes during sleep due to upper airway obstruction. The present review summarizes current knowledge on inter-relationships between OSA and type 2 diabetes mellitus (T2DM) and suggests the former as a possible target for sodium-glucose co-transporter-2 inhibitors (SGLT-2i). Based on pathophysiological mechanisms underlying OSA onset and renal SGLT-2 effects, we suggest that SGLT-2i indications might expand beyond current ones, including glucose, lipids, uric acid, blood pressure, and body weight control as well as chronic heart failure and kidney disease prevention.

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<p>Nocturnal Mean Oxygen Saturation Is Associated with Secondary Polycythemia in Young Adults with Obstructive Sleep Apnea, Especially in Men</p>

Cited by 21 publications

References 39 publications

Obstructive Sleep Apnea is Associated with an Increased Prevalence of Polycythemia in Patients with Chronic Obstructive Pulmonary Disease

Obstructive Sleep Apnea is Associated with an Increased Prevalence of Polycythemia in Patients with Chronic Obstructive Pulmonary Disease

Is obstructive sleep apnea associated with erythrocytosis? A systematic review and meta‐analysis

Possible Preventative/Rehabilitative Role of Gliflozins in OSA and T2DM. A Systematic Literature Review-Based Hypothesis

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