&lt;p&gt;Onco-Metabolic Surgery: A Combined Approach to Gastric Cancer and Hypertension&lt;/p&gt;

Peng, Dong; Cheng, Yu-Xi; Tao, Wei; Zou, Yingying; Qian, Kun; Zhang, Wei

doi:10.2147/cmar.s260147

Cited by 19 publications

(17 citation statements)

References 28 publications

(45 reference statements)

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“…In bariatric surgery, patients had T2DM improvement and apparently lower microvascular and macrovascular disease and mortality after surgery (23). Similarly, patients had remission of T2DM and hypertension after gastric cancer surgery (14,24), and onco-metabolic surgery occurred. There were some reasons and theories accounting for the remission of T2DM.…”

Section: Discussionmentioning

confidence: 99%

Improvement of Diabetes Mellitus After Colorectal Cancer Surgery: A Retrospective Study of Predictive Factors For Type 2 Diabetes Mellitus Remission and Overall Survival

et al. 2021

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PurposeThe purpose of the current study was to evaluate the impact of colorectal cancer (CRC) surgery on type 2 diabetes mellitus (T2DM) and to analyze the change in T2DM on overall survival after CRC surgery.MethodsPatients who underwent CRC surgery were retrospectively enrolled from January 2013 to December 2019. The status of T2DM pre- and 1-year after CRC surgery was recorded, and predictive factors for T2DM remission and overall survival were analyzed.ResultsA total of 296 patients were included in this study. Thirty-eight patients experienced remission of T2DM 1 year after CRC surgery, and the remission rate was 12.8%. Weight loss was significantly higher in the T2DM remission group (p = 0.038), and the T2DM duration was significantly shorter in the T2DM remission group (p = 0.015). In the multivariate logistic regression analysis, higher weight loss (p = 0.046, odds ratio = 1.060, 95% CI = 1.001–1.122) and shorter T2DM duration (p = 0.019, odds ratio = 1007, 95% CI = 1.001–1.014) were predictive factors for remission of T2DM. Furthermore, in multivariate Cox regression analysis, lower TNM stage (p = 0.000, odds ratio = 2.147, 95% CI = 1.474–3.128) and T2DM remission (p = 0.033, odds ratio = 2.999, 95% CI = 1.091–8.243) were the predictive factors for better overall survival.ConclusionPatients with concurrent CRC and T2DM had a 12.8% remission 1 year after CRC surgery. Higher weight loss and shorter T2DM duration contributed to T2DM remission, and patients with T2DM remission could improve in terms of their overall survival.

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Section: Discussionmentioning

confidence: 99%

Improvement of Diabetes Mellitus After Colorectal Cancer Surgery: A Retrospective Study of Predictive Factors For Type 2 Diabetes Mellitus Remission and Overall Survival

et al. 2021

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“…GC patients also experience hypertension remission after gastrectomy. Peng et al [ 15 ] conducted a retrospective study of 143 patients who underwent gastrectomy and the resulting effects on hypertension and found that the hypertension complete remission rate was 55.3%. In addition, age and total gastrectomy were predictors of hypertension remission 6 mo after gastrectomy[ 15 ].…”

Section: Hypertension Remissionmentioning

confidence: 99%

“…Peng et al [ 15 ] conducted a retrospective study of 143 patients who underwent gastrectomy and the resulting effects on hypertension and found that the hypertension complete remission rate was 55.3%. In addition, age and total gastrectomy were predictors of hypertension remission 6 mo after gastrectomy[ 15 ]. Wang et al [ 19 ] compared hypertension remission between total gastrectomy and subtotal gastrectomy in non-obese non-diabetic GC patients and found that total gastrectomy itself, beyond weight loss, was associated with hypertension remission[ 19 ].…”

Section: Hypertension Remissionmentioning

confidence: 99%

“…Lee et al [ 12 ] reported the largest number of patients ( n = 351) from nationwide data, and after a follow-up of 36.7 mo, only 11.1% of patients experienced hypertension remission; however, the results analyzed were based on nationwide data, and limited baseline information was available[ 12 ]. Therefore, the hypertension remission rate after gastrectomy was 11.1%-57.6% (Table 2 ), and Peng et al [ 15 ] proposed that total gastrectomy is an oncometabolic surgery that can cure younger patients with concurrent GC and hypertension[ 15 ].…”

Section: Hypertension Remissionmentioning

confidence: 99%

“…It has been reported that insulin resistance improves and fasting blood glucose returns to normal after gastrectomy, although controversy regarding the mechanism underlying this remission still exists[ 14 ]. There was a retrospective study of 143 patients in which the hypertension remission rate after gastrectomy was evaluated[ 15 ], and it was relatively less than the T2DM remission rate reported in previous studies.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effect of oncometabolic surgery on gastric cancer: The remission of hypertension, type 2 diabetes mellitus, and beyond

Cheng¹,

Peng²,

Tao³

et al. 2021

WJGO

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This review summarizes the definition and surgical methods of oncometabolic surgery according to previous studies. Then, the authors discuss the beneficial effects observed after gastrectomy in gastric cancer (GC) patients with concurrent hypertension or type 2 diabetes mellitus (T2DM). The authors summarize the current studies analyzing the remission rate and the hypotheses of the mechanisms underlying these effects. The remission rate ranged from 42.5%-65.4% in T2DM patients and from 11.1%-57.6% among those with hypertension. Furthermore, the remission of T2DM could have an impact on overall survival rates as well. The mechanisms underlying the remission of hypertension and T2DM is unclear in current studies, but oncometabolic surgery is expected to be applied in clinical practice. In addition, the effect of oncometabolic surgery on other chronic metabolic comorbidities is expected to be proven in further studies. Therefore, the purpose of this review is to discuss the effects of oncometabolic surgery reported in current studies with a primary focus on the remission of hypertension and T2DM after gastrectomy in GC patients. The possibility of the remission of other metabolic comorbidities in GC patients who undergo oncometabolic surgery is also discussed.

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Hyperuricemia remission after colorectal cancer surgery for colorectal cancer patients

Liu,

Huang,

et al. 2023

Sci Rep

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The purpose of this study was to investigate whether patients with colorectal cancer (CRC) combined with hyperuricemia remitted 1 year after CRC surgery. CRC patients combined with hyperuricemia who underwent radical surgery were included from a single clinical center from Jan 2016 to Dec 2021. Baseline characteristics was compared between the remission group and the non-remission group. Multivariate logistic regression was used to find the possible predictive factors of hyperuricemia remission. A total of 91 patients were included for data analysis, retrospectively. There were 34 (37.4%) patients in the remission group and 57 (62.6%) patients in the non-remission group. The mean preoperative weight and body mass index (BMI) were 61.2 ± 10.7 (kg) and 24.1 ± 3.3 (kg/m2). 21 (23.1%) patients had a history of drinking. We found that the weight and BMI were not significantly different before and 1 year after CRC surgery (P > 0.05). In contrast, uric acid values were significantly decreased (P < 0.01). Meanwhile, the outcomes showed there were no significant differences in the baseline characteristics between the remission and non-remission groups (P > 0.05). According to multivariate logistic regression, we found that the history of drinking was a predictive factor of hyperuricemia remission (OR = 0.046, 95% CI 0.005–0.475, P = 0.010). CRC patients with hyperuricemia had a 37.4% remission from hyperuricemia 1 year after CRC surgery. Tumor location, tumor stage, and tumor size did not predict the remission of hyperuricemia. Notably, the history of drinking was a predictive factor of hyperuricemia remission.

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<p>Onco-Metabolic Surgery: A Combined Approach to Gastric Cancer and Hypertension</p>

Cited by 19 publications

References 28 publications

Improvement of Diabetes Mellitus After Colorectal Cancer Surgery: A Retrospective Study of Predictive Factors For Type 2 Diabetes Mellitus Remission and Overall Survival

Improvement of Diabetes Mellitus After Colorectal Cancer Surgery: A Retrospective Study of Predictive Factors For Type 2 Diabetes Mellitus Remission and Overall Survival

Effect of oncometabolic surgery on gastric cancer: The remission of hypertension, type 2 diabetes mellitus, and beyond

Hyperuricemia remission after colorectal cancer surgery for colorectal cancer patients

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