&lt;p&gt;Optimizing compliance with surgical antimicrobial prophylaxis guidelines in patients undergoing gastrointestinal surgery at a referral teaching hospital in southern Iran: clinical and economic impact [Corrigendum]&lt;/p&gt;

Mahmoudi, Laleh; Ghouchani, Mehrdad; Birjand, Motahareh Mahi; Bananzadeh, Alimohammad; Akbari, Ali

doi:10.2147/idr.s228699

Cited by 2 publications

(3 citation statements)

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“…Receiving invasive procedures is a wellestablished risk factor of nosocomial BSI, and therefore antimicrobial prophylaxis before or after a procedure is indicated in some situations [10][11][12][13]. However, there are also concerns about the inappropriateness of surgical antimicrobial prophylaxis [14][15][16], which may lead to unnecessary cost and contribute to the development and spread of antimicrobial resistance [17][18][19]. For cardiac surgery, routine antibiotic prophylaxis is generally recommended given the significant and large benefit observed in trials, although detailed recommendations on duration and timing varies between guidelines [20]; while for interventional cardiac catheterization, antibiotic prophylaxis is only recommended for patients at high risk of infective endocarditis [21,22].…”

Section: Introductionmentioning

confidence: 99%

Incidence, Clinical Features, and Association with Prognosis of Bloodstream Infection in Pediatric Patients After Percutaneous or Surgical Treatment for Ventricular Septal Defect or Atrial Septal Defect: A Retrospective Cohort Study

Chen

Huang

et al. 2022

Infect Dis Ther

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Introduction Bloodstream infection (BSI) may occur after cardiac procedures, but this has rarely been investigated specifically in pediatric patients after percutaneous or surgical treatment for ventricular septal defect (VSD) or atrial septal defect (ASD) with recent data. The current study aimed to investigate the incidence, clinical features, and association with prognosis of BSI in this patient population. Methods Pediatric patients who received percutaneous or surgical procedure for VSD or ASD between 2010 and 2018 in a large children’s hospital in China were retrospectively enrolled via the Pediatric Intensive Care database, but only those who had blood culture records within 24 h after the procedure and who had no prior positive blood culture records were included. BSI after the procedure was identified by reviewing blood culture records, and baseline characteristics associated with BSI were explored by univariable logistic regression. In-hospital mortality and length of hospitalization were studied as prognostic outcomes and compared between patients with and without BSI. Results A total of 1340 pediatric patients were included. Among them, 46 (3.43%) patients had BSI within 24 h after the procedure, of which the majority (78.26%, 36/46) were caused by Gram-positive bacteria and 65.22% (30/46) had antibiotic-resistant organisms. Age [odds ratio (OR) 0.98 per 1-month increase, 95% confidence interval (CI) 0.97–1.00, P = 0.021] and antibiotic use within 72 h before the procedure (OR 1.81, 95% CI 1.00–3.26, P = 0.049) were statistically significantly associated with developing BSI. Compared with patients without BSI, there was no statistically significant difference in in-hospital mortality (0.00% versus 0.54%, P = 1.000), but patients with BSI had statistically significantly longer length of hospitalization (median 14.51 versus 12.94 days, P = 0.006), while the association was not statistically significant after adjustment for baseline characteristics by multivariable linear regression ( β = 1.73, 95% CI −0.59 to 4.04, P = 0.144). Conclusion BSI is relatively uncommon in pediatric patients after procedures for VSD or ASD, but a younger age seems a risk factor. Developing BSI appears to be associated with increased length of hospitalization but not in-hospital mortality. Supplementary Information The online version contains supplementary material available at 10.1007/s40121-022-00702-z.

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Section: Introductionmentioning

confidence: 99%

Incidence, Clinical Features, and Association with Prognosis of Bloodstream Infection in Pediatric Patients After Percutaneous or Surgical Treatment for Ventricular Septal Defect or Atrial Septal Defect: A Retrospective Cohort Study

Chen

Huang

et al. 2022

Infect Dis Ther

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“…[7][8][9] Given the well-established instructions, an appropriate antibiotic/antimicrobial agent should protect patients against SSI-causing pathogens, be established at the appropriate time, and be administered only for 24 h. 10 Despite the accessibility to these surgical prophylaxis guidelines, studies evaluating surgical prophylaxis demonstrated that inappropriate timing of antibiotic administration, inappropriate antibiotic prescribing, and long duration of antibiotic therapy develop complications in surgical prophylaxis. [11][12][13] Overall agreement for the application of prophylactic antibiotic guidelines is widely diverse with low-frequency in the world, ranging from less than 1% in Iran 14,15 and Korea 16 to 28%, 33.2%, 36.3%, and 41.1% in Dutch 5 Malaysian, 17 Greek, 18 and French, 19 respectively.…”

Section: Introductionmentioning

confidence: 99%

“…Despite the accessibility to these surgical prophylaxis guidelines, studies evaluating surgical prophylaxis demonstrated that inappropriate timing of antibiotic administration, inappropriate antibiotic prescribing, and long duration of antibiotic therapy develop complications in surgical prophylaxis. 11-13…”

Section: Introductionmentioning

confidence: 99%

Compliance with Antibiotics Prophylaxis Guideline in Surgical Patients in ICUs of a Teaching Referral Hospital

Vazin

Hatami-Mazinani

Alemzadeh

et al. 2022

Health�Serv�Insights

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Antimicrobial prophylaxis used for surgical procedures remains one of the measures for the prevention of surgical site infections (SSIs). The present study was designed to assess the compliance with clinical practice guideline for antimicrobial prophylaxis in variable surgeries conducted in the intensive care units (ICUs) of a major referral hospital. This cross-sectional investigation was carried out by prospective data collected from October 2017 to March 2018 in the intensive care unit (ICU) of Nemazi hospital in Shiraz. Demographic characteristics, surgery type as well as antibiotic treatment were gathered from medical records and entered in data collection forms. We reviewed compliance and adherence of prophylactic antibiotic administration to the Infectious Diseases Society of America (IDSA) guideline and evaluated the courses of antimicrobial drugs. If an antibiotic administrated for surgical prophylaxis was different from the guideline, the antibiotic was classified as non-guideline-based antibiotics. Most patients participated in this study were male (64.5%). Only 8.75% of the administrated antibiotics chosen for surgical prophylaxis were found to be appropriate antibiotic prescriptions; however, those patients receiving appropriate antibiotics prescribed an inappropriate dosage. In addition, the antibiotics were administrated with inappropriate durations in all cases. Our findings indicated that adherence to the IDSA international guideline seems to be far from ideal in Namazi hospital for antimicrobial prophylaxis, resulting in the unsuitable administration of a wide variety of antibiotics.

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<p>Optimizing compliance with surgical antimicrobial prophylaxis guidelines in patients undergoing gastrointestinal surgery at a referral teaching hospital in southern Iran: clinical and economic impact [Corrigendum]</p>

Cited by 2 publications

References 0 publications

Incidence, Clinical Features, and Association with Prognosis of Bloodstream Infection in Pediatric Patients After Percutaneous or Surgical Treatment for Ventricular Septal Defect or Atrial Septal Defect: A Retrospective Cohort Study

Incidence, Clinical Features, and Association with Prognosis of Bloodstream Infection in Pediatric Patients After Percutaneous or Surgical Treatment for Ventricular Septal Defect or Atrial Septal Defect: A Retrospective Cohort Study

Compliance with Antibiotics Prophylaxis Guideline in Surgical Patients in ICUs of a Teaching Referral Hospital

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