<p>Outcomes of therapeutic keratoplasty for severe infectious keratitis in Chongqing, a 16-year experience</p>

Abstract

Purpose This study aimed to evaluate the outcomes of therapeutic keratoplasty for severe infectious keratitis in Chongqing (Southwest China). Patients and methods The records of 561 eyes that underwent therapeutic keratoplasty for refractory microbial keratitis from 2001 to 2016 were analyzed in this retrospective study. Data included demographic information, microbiological investigations, associated factors, graft size, preoperative status, postoperative complications, and final anatomical outcomes. Results Trauma was the most common cause (267, 47.6%) for corneal ulcers leading to therapeutic keratoplasty. The etiological diagnosis included bacterial keratitis (80 eyes, 14.3%), fungal keratitis (317 eyes, 56.5%), acanthamoeba keratitis (3 eyes, 0.5%), and mixed bacteria/fungal infection (15 eyes, 2.7%). Anatomical success was achieved for 492 eyes (87.7%), with bacterial keratitis having a better outcome than fungal and mixed infections. Diabetes and preoperative time ≥30 days were significantly associated with anatomical failure in the multivariate logistic regression ( P =0.028 and P =0.022, respectively). Patients with hypopyon, corneal perforation, surgical delay, and/or large graft size had a higher incidence of postoperative complications (reinfection, cataract, glaucoma, hyphema, or graft rejection) ( P <0.05). Conclusion Therapeutic keratoplasty was an effective procedure in managing refractory infectious keratitis. Prompt and appropriate surgery would result in fewer complications and better outcomes.

Post-keratoplasty Infectious Keratitis: Epidemiology, Risk Factors, Management, and Outcomes

“…This is reflected within a study conducted in India whereby 75% of patients were from rural communities, with a high rate (28%) of PKIK being observed ( 45 ). Additionally, a China study reported farmers to be a significant independent risk factor of PKIK due to higher risk of trauma, particularly from plants resulting in fungal keratitis ( 57 ). These populations also have a higher risk for non-compliance of post-operative medication administration and hygiene ( 58 ).…”

Genipin in an Ex Vivo Corneal Model of Bacterial and Fungal Keratitis

“… 22 – 24 In severe cases of medically uncontrollable infectious keratitis, surgical interventions and corneal keratoplasty are the last therapeutic alternatives; however, these are often associated with poor visual outcomes and increased risks of graft rejection/failure. 25 – 27 Moreover, major shortage of corneal graft, with only one in 70 patients worldwide having access to donor tissue is an additional challenge. 28 …”

Analysis of Indoor Particle Diffusion in Attached Jet Air Supply System

“…Using the discrete model in CFD, namely DPM model, which in practical application is suitable for cases where the volume fraction of discrete phase in fluid domain is less than 10 ~12% [7][8] . In this paper, the Euler-Lagrange method is used to calculate the flow states associated with continuous phase and discrete phase, and the one-way coupling [9][10] method is used. See Table 1 for particle parameter settings.…”