&lt;p&gt;Perioperative Analgesic Effects of Preemptive Ultrasound-Guided Rectus Sheath Block Combined with Butorphanol or Sufentanil for Single-Incision Laparoscopic Cholecystectomy: A Prospective, Randomized, Clinical Trial&lt;/p&gt;

Fu, Huimin; Zhong, Chaochao; Fu, Yu; Gao, Yongtao; Xu, Xingguo

doi:10.2147/jpr.s252952

Cited by 8 publications

(6 citation statements)

References 25 publications

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“…The incidence of visceral pain was significantly lower in the butorphanol group at 10, 20, and 30 min after recovery. This is consistent with most previous studies [ 21 , 22 ].…”

Section: Discussionsupporting

confidence: 94%

Effect of butorphanol on visceral pain in patients undergoing gastrointestinal endoscopy: a randomized controlled trial

Wang

Liu

et al. 2023

BMC Anesthesiol

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Background Butorphanol slightly influences the respiratory and circulatory systems, has a better effect on relieving the discomfort caused by mechanical traction, and has a low incidence of postoperative nausea and vomiting (PONV). Combined butorphanol and propofol may suppress postoperative visceral pain, which is avoidable in gastrointestinal endoscopy. Thus, we hypothesized that butorphanol could decrease the incidence of postoperative visceral pain in patients undergoing gastroscopy and colonoscopy. Methods This was a randomized, placebo-controlled, and double-blinded trial. Patients undergoing gastrointestinal endoscopy were randomized to intravenously receive either butorphanol (Group I) or normal saline (Group II). The primary outcome was visceral pain after the procedure 10 min after recovery. The secondary outcomes included the rate of safety outcomes and adverse events. Postoperative visceral pain was defined as a visual analog scale (VAS) score ≥ 1. Results A total of 206 patients were enrolled in the trial. Ultimately, 203 patients were randomly assigned to Group I (n = 102) or Group II (n = 101). In total, 194 patients were included in the analysis: 95 in Group I and 99 in Group II. The incidence of visceral pain at 10 min after recovery was found to be statistically lower with butorphanol than with the placebo (31.5% vs. 68.5%, respectively; RR: 2.738, 95% CI [1.409–5.319], P = 0.002), and the notable difference was in pain level or distribution of visceral pain (P = 0.006). Conclusions The trial indicated that adding butorphanol to propofol results in a lower incidence of visceral pain after surgery without noticeable fluctuations in circulatory and respiratory functions for gastrointestinal endoscopy patients. Trial registration Clinicaltrials.gov NCT04477733 (PI: Ruquan Han; date of registration: 20/07/2020).

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“…The incidence of visceral pain was significantly lower in the butorphanol group at 10, 20, and 30 min after recovery. This is consistent with most previous studies [ 21 , 22 ].…”

Section: Discussionsupporting

confidence: 94%

Effect of butorphanol on visceral pain in patients undergoing gastrointestinal endoscopy: a randomized controlled trial

Wang

Liu

et al. 2023

BMC Anesthesiol

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“…These include erector spinae plane block, serratus intercostal plane block, oblique subcostal TAP, and quadratus lumborum block. 12 - 15 …”

Section: Discussionmentioning

confidence: 99%

A Randomized Double-Blind Study Evaluating Intraperitoneal Ropivacaine Nebulization With and Without Nalbuphine for Post-operative Analgesia in Laparoscopic Cholecystectomy

Gowda

Govil

Kumar

et al. 2022

Turk J Anaesthesiol Reanim

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Objective: Local anaesthetics administered into the peritoneal cavity have been successfully used for post-operative pain relief in minimally invasive laparoscopic procedures. We intended to study and compare nebulized intraperitoneal ropivacaine with and without nalbuphine, with a placebo for post-operative pain relief in these surgeries. Methods: A prospective, randomized double-blinded study was conducted over a period of 1 year after institutional ethical clearance, in patients undergoing elective laparoscopic cholecystectomy. Subjects were randomized into 3 groups (S: saline, R: ropivacaine, RN: ropivacaine plus nalbuphine). The pain was assessed in the post-operative period using NRS scores (up to 24 hours). Kruskal-Wallis test was used for comparison, P < .05 was considered significant. Time to first rescue analgesia, total opioid requirement, and side effects were also recorded. Results: Groups were similar in terms of demographic data. Patients in the placebo group reported higher NRS scores than the other 2 study groups till 4 hours post-operative (earlier rescue analgesia). The addition of nalbuphine did not cause any statistically significant improvement in post-operative pain relief (NRS) as compared to ropivacaine administered alone. Intraperitoneal ropivacaine nebulization had no significant adverse effect as compared to placebo. Conclusions: Ropivacaine nebulization with or without nalbuphine is more effective than placebo for post-operative pain relief after laparoscopic cholecystectomy without significant side effects. Addition of nalbuphine to ropivacaine nebulization does not significantly improve pain relief after laparoscopic cholecystectomy.

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“… 22 Studies have shown that butorphanol can also relieve visceral pain, but butorphanol reduces visceral pain in a dose-dependent manner. 30 , 31 Furthermore, there were insufficient evidence to make conclusions regarding the effectiveness of opioids at relieving pain from uterine cramping. 32 Previous studies have found that DEX is effective in controlling visceral pain.…”

Section: Discussionmentioning

confidence: 99%

The Effectiveness and Safety of Intravenous Dexmedetomidine of Different Concentrations Combined with Butorphanol for Post-Caesarean Section Analgesia: A Randomized Controlled Trial

Liu¹,

Peng²,

Hu³

et al. 2021

DDDT

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Purpose The present study aimed to determine the effectiveness of intravenous dexmedetomidine of different concentrations and to evaluate its maternal and neonatal safety when combined with butorphanol in parturients undergoing cesarean section. Patients and Methods A total of 114 parturients between 24 and 43 years of age, with singleton pregnancy who underwent elective cesarean section under epidural anesthesia, were randomly allocated to four groups: group C received 0.9% sodium chloride after delivery, followed by butorphanol (3 μg·kg −1 ·h −1 ); patients in groups D1, D2, and D3 received 0.5 μg·kg −1 ·h −1 dexmedetomidine after delivery, followed by butorphanol (3 μg·kg −1 ·h −1 ) combined with dexmedetomidine 0.03, 0.05, and 0.08 μg·kg −1 ·h −1 , respectively. The primary outcome was the visual analogue scale (VAS) score at 6 h after delivery when patients were at rest. Secondary outcome measures included VAS after delivery when patients were on movement and uterine cramping, Ramsay sedation scale (RSS), relative infant dose (RID) of dexmedetomidine, satisfaction with analgesia after surgery and symptoms of CNS depression in neonates. Results There were no significant differences in patient characteristics among the groups ( P > 0.05). The VAS at all timepoints after delivery in groups D2 and D3 were significantly lower than in groups C and D1 ( P < 0.001). RSS scores were clearly higher in group D3 than in the other three groups at 6 h and 12 h ( P < 0.0001). RID in groups D1, D2, and D3 was 0.171%, 0.197%, and 0.370%, respectively. Compared with group D1, RID was higher in group D3 ( P = 0.0079). Degree of satisfaction with analgesia was higher in groups D2 and D3 ( P < 0.005). Conclusion Continuous intravenous infusion of 0.05 μg·kg −1 ·h −1 dexmedetomidine combined with 3 μg·kg −1 ·h −1 butorphanol could be safely applied in healthy parturients with satisfactory analgesia after cesarean section without changes in sedation.

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<p>Perioperative Analgesic Effects of Preemptive Ultrasound-Guided Rectus Sheath Block Combined with Butorphanol or Sufentanil for Single-Incision Laparoscopic Cholecystectomy: A Prospective, Randomized, Clinical Trial</p>

Cited by 8 publications

References 25 publications

Effect of butorphanol on visceral pain in patients undergoing gastrointestinal endoscopy: a randomized controlled trial

Effect of butorphanol on visceral pain in patients undergoing gastrointestinal endoscopy: a randomized controlled trial

A Randomized Double-Blind Study Evaluating Intraperitoneal Ropivacaine Nebulization With and Without Nalbuphine for Post-operative Analgesia in Laparoscopic Cholecystectomy

The Effectiveness and Safety of Intravenous Dexmedetomidine of Different Concentrations Combined with Butorphanol for Post-Caesarean Section Analgesia: A Randomized Controlled Trial

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