&lt;p&gt;Personalized medicine in breast cancer: pharmacogenomics approaches&lt;/p&gt;

Jeibouei, Shabnam; Akbari, Mohammad Esmaeil; Kalbasi, Alireza; Aref, Amir Reza; Ajoudanian, Mohammad; Rezvani, Alireza; Zali, Hakimeh

doi:10.2147/pgpm.s167886

Cited by 54 publications

(58 citation statements)

References 159 publications

(161 reference statements)

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“…Unlike other cancers, hormone therapy and HER2-targeted therapy are possible depending on the characteristics and subtype of the patients with breast cancer [108,109]. Because heterogeneity of breast cancer subtypes is the most common cause of therapy failure, it is important to proceed with research or development of therapeutic agents considering breast cancer subtypes [110]. On the other hand, the sensitivity of L-AA in breast cancer cells is known to correlate with the expression of sodium-dependent vitamin C transporter-2 (SVCT-2), which transports L-AA to cells [58].…”

Section: Discussionmentioning

confidence: 99%

L-Ascorbic Acid Inhibits Breast Cancer Growth by Inducing IRE/JNK/CHOP-Related Endoplasmic Reticulum Stress-Mediated p62/SQSTM1 Accumulation in the Nucleus

et al. 2020

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Anticancer effects of L-ascorbic acid (Vitamin C, L-AA) have been reported in various types of cancers. L-AA intake reduces breast cancer recurrence and mortality; however, the role of L-AA in the treatment of breast cancer remains poorly understood. In this study, we investigated the effect and mechanism action of L-AA on breast cancer growth. L-AA inhibited the growth of breast cancer cells by inducing apoptotic cell death at the evaluated treatment concentrations without affecting normal cells. Moreover, L-AA induces autophagosome formation via regulation of mammalian target of rapamycin (mTOR), Beclin1, and autophagy-related genes (ATGs) and increased autophagic flux. Notably, we observed that L-AA increased p62/SQSTM1 (sequestosome 1) protein levels. Accumulation of p62 protein in cancer cells in response to stress has been reported, but its role in cancer regulation remains controversial. Here, we demonstrated that L-AA-induced p62 accumulation is related to L-AA-induced breast cancer growth inhibition. Furthermore, L-AA induced endoplasmic reticulum (ER) stress via the IRE–JNK–CHOP (inositol-requiring endonuclease–c-Jun N-terminal kinase–C/EBP homologous protein) signaling pathways, which increased the nuclear levels of p62/SQSTM1. These findings provide evidence that L-AA-induced ER stress could be crucial for p62 accumulation-dependent cell death, and L-AA can be useful in breast cancer treatment.

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Section: Discussionmentioning

confidence: 99%

L-Ascorbic Acid Inhibits Breast Cancer Growth by Inducing IRE/JNK/CHOP-Related Endoplasmic Reticulum Stress-Mediated p62/SQSTM1 Accumulation in the Nucleus

et al. 2020

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“…Unfortunately, with a few exceptional cases of highly penetrant mutations; most cancer patients have not benefited from these approaches ( 44 , 45 ). Due to tumor mutational heterogeneity, most cancer mutations are rare, subclonal, often not causal and hence poorly annotated.…”

Section: Pathway-based Drug Repurposingmentioning

confidence: 99%

Pathway-Based Drug-Repurposing Schemes in Cancer: The Role of Translational Bioinformatics

Hernández‐Lemus

Martínez-García

2021

Front. Oncol.

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Cancer is a set of complex pathologies that has been recognized as a major public health problem worldwide for decades. A myriad of therapeutic strategies is indeed available. However, the wide variability in tumor physiology, response to therapy, added to multi-drug resistance poses enormous challenges in clinical oncology. The last years have witnessed a fast-paced development of novel experimental and translational approaches to therapeutics, that supplemented with computational and theoretical advances are opening promising avenues to cope with cancer defiances. At the core of these advances, there is a strong conceptual shift from gene-centric emphasis on driver mutations in specific oncogenes and tumor suppressors—let us call that the silver bullet approach to cancer therapeutics—to a systemic, semi-mechanistic approach based on pathway perturbations and global molecular and physiological regulatory patterns—we will call this the shrapnel approach. The silver bullet approach is still the best one to follow when clonal mutations in driver genes are present in the patient, and when there are targeted therapies to tackle those. Unfortunately, due to the heterogeneous nature of tumors this is not the common case. The wide molecular variability in the mutational level often is reduced to a much smaller set of pathway-based dysfunctions as evidenced by the well-known hallmarks of cancer. In such cases “shrapnel gunshots” may become more effective than “silver bullets”. Here, we will briefly present both approaches and will abound on the discussion on the state of the art of pathway-based therapeutic designs from a translational bioinformatics and computational oncology perspective. Further development of these approaches depends on building collaborative, multidisciplinary teams to resort to the expertise of clinical oncologists, oncological surgeons, and molecular oncologists, but also of cancer cell biologists and pharmacologists, as well as bioinformaticians, computational biologists and data scientists. These teams will be capable of engaging on a cycle of analyzing high-throughput experiments, mining databases, researching on clinical data, validating the findings, and improving clinical outcomes for the benefits of the oncological patients.

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“…Personalized medicine is based on tumor molecular profiles, and it is currently applied at different stages of breast cancer, including, especially, the prediction of treatment efficacy. One typical example of personalized medicine is represented by therapies implemented among patients with HER2-positive breast cancer compared to HER2-negative [ 32 ]. Moreover, a great challenge remains for the treatment of triple-negative breast cancer.…”

Section: Emerging Metabolic Aspects: Do They Have a Key Role In Mbmentioning

confidence: 99%

Locoregional Surgery in Metastatic Breast Cancer: Do Concomitant Metabolic Aspects Have a Role on the Management and Prognosis in this Setting?

Amabile

Frusone

Luca

et al. 2020

JPM

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Although they cannot be considered curative, the new therapeutic integrated advances in metastatic breast cancer (MBC) have substantially improved patient outcomes. Traditionally, surgery was confined to palliation of symptomatic or ulcerating lumps. Data suggest, in some cases, a possible additive role for more aggressive locoregional surgical therapy in combination with systemic treatments in the metastatic setting, although a low level of evidence has been shown in terms of improvement in overall survival in MBC patients treated with surgery and medical treatment compared to medical treatment alone. In this light, tumor heterogeneity remains a challenge. To effectively reshape the therapeutic approach to MBC, careful consideration of who is a good candidate for locoregional resection is paramount. The patient’s global health condition, impacting on cancer progression and morbidity and their associated molecular targets, have to be considered in treatment decision-making. In particular, more recently, research has been focused on the role of metabolic derangements, including the presence of metabolic syndrome, which represent well-known conditions related to breast cancer recurrence and distant metastasis and are, therefore, involved in the prognosis. In the present article, we focus on locoregional surgical strategies in MBC and whether concomitant metabolic derangements may have a role in prognosis.

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<p>Personalized medicine in breast cancer: pharmacogenomics approaches</p>

Cited by 54 publications

References 159 publications

L-Ascorbic Acid Inhibits Breast Cancer Growth by Inducing IRE/JNK/CHOP-Related Endoplasmic Reticulum Stress-Mediated p62/SQSTM1 Accumulation in the Nucleus

L-Ascorbic Acid Inhibits Breast Cancer Growth by Inducing IRE/JNK/CHOP-Related Endoplasmic Reticulum Stress-Mediated p62/SQSTM1 Accumulation in the Nucleus

Pathway-Based Drug-Repurposing Schemes in Cancer: The Role of Translational Bioinformatics

Locoregional Surgery in Metastatic Breast Cancer: Do Concomitant Metabolic Aspects Have a Role on the Management and Prognosis in this Setting?

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