<p>Platelet-Mimicking Drug Delivery Nanoparticles for Enhanced Chemo-Photothermal Therapy of Breast Cancer</p>

Abstract

Background Traditional nanoparticle-based drug delivery systems suffer from several limitations, such as easy clearance from blood and inaccurate targeting. Materials and Methods Here, we developed platelet membrane-coated nanoparticles (PM-NPs) to improve the precise delivery of drugs to tumor sites and enable a more efficient photothermal therapy (PTT) treatment. Results Mimicking the natural platelet membrane, nanoparticles containing drugs and photothermal agents were not recognized and cleared by the immune system; they could circulate in the blood for a long time and accumulate more efficiently at the tumor site, thus releasing more antitumor drugs and achieving better PTT effects. It is worth mentioning that, in this study, we found that tumors in mice treated with the platelet-mimicking nanoparticles were completely eliminated without recurrence during the observation period (up to 18 days). Conclusion This study provides a new strategy to design delivery systems of drugs or photothermal agents, whether in biotherapy or other fields.

Research Progress on Cell Membrane-Coated Biomimetic Delivery Systems

“…In vivo experiments used near-infrared fluorescence imaging to detect NPs in vivo and assess tumor targeting and biological distribution, and showed that the system has a longer retention time and accumulation effect. Further evaluation of the combined thermal therapy and tumor-targeting system found that the tumor growth in the laser NP group was completely restrained compared with the system without thermal ablation ( Pei et al, 2020 ).…”

Platelet Membrane Biomimetic Nanoparticles Combined With UTMD to Improve the Stability of Atherosclerotic Plaques

“…In recent years, nanomedicine has been widely used for the targeted therapy of atherosclerosis ( Yu et al, 2020 ; Costagliola di Polidoro et al, 2021 ; Craparo et al, 2021 ), but there are still challenges in developing a safe, effective and convertible nanoplatform. PLGA nanoparticles have been widely used in research due to their good stability, perfect biodegradability, and ideal biocompatibility ( Hu et al, 2015 ; Wang et al, 2018 ; Pei et al, 2020 ). RAP is a new type of immunosuppressant with excellent antiproliferative ability.…”

Characterization and Therapeutic Use of Extracellular Vesicles Derived from Platelets

“…Due to the composition of the surrounding membrane, their biological cargo is protected from rapid catabolism and processing by macrophages [ 46 ]. PL-EVs are free to move with body fluids, so they can also be regarded as nano-delivery treatments [ 47 , 48 ]. However, the number and final cargo of PL-EVs is mainly affected by the activation process with agonists or mediators, hemodynamic stress, ageing and inflammatory pathologies [ 49 ].…”