&lt;p&gt;Predictive Value of Lymphocyte-Related Blood Parameters at the Time Point of Lymphocyte Nadir During Radiotherapy in Breast Cancer&lt;/p&gt;

Liu, Jiannan; Ma, Feiyan; Sun, Bing; Cong, Yang; Liu, Xuan; Wang, Qian; Wu, Shikai

doi:10.2147/ott.s233244

Cited by 7 publications

(13 citation statements)

References 31 publications

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“…19–38 The characteristics of the included studies are summarized in Table 1. The 20 studies 19–38 were published between 2014 and 2021 with the sample size ranging from 62 to 1083; 12 studies were carried out in Asian countries and 8 studies in other regions. Pathological types included HER2 positive and negative.…”

Section: Resultsmentioning

confidence: 99%

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Platelet-to-lymphocyte ratio associated with the clinicopathological features and prognostic value of breast cancer: A meta-analysis

Gong

Xin²,

et al. 2022

Int J Biol Markers

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Objective The association of platelet-to-lymphocyte ratio (PLR) with the clinicopathological features and prognosis in patients with breast cancer was evaluated. Method Related studies were searched from PubMed, Embase, Cochrane Library, and Web of Science up to July 1, 2021. Then, basic characteristic and prognostic data were extracted from the included studies. We synthesized and compared primary outcomes such as overall survival. Subgroups analyses in pathology, geographical area, follow-up time, and sample size were conducted. The pooled hazard ratio (HR), odds ratio (OR), and 95% confidence interval (CI) served as measures to assess the relationship of PLR with prognosis and clinicopathological features of breast cancer patients. After literature retrieval and selection, 20 studies with 7484 patients were included in this meta-analysis. Results High PLR was significantly related to poor overall survival (HR = 1.88; 95% CI 1.61, 2.19; P < 0.001) in breast cancer patients. Also, high PLR was associated with lymph node metastasis (LNM) (OR = 1.82; 95% CI 1.32, 2.52; P < 0.001), advanced tumor-node-metastasis (TNM) stage (OR = 1.89; 95% CI 1.25, 2.87; P = 0.003), and distant metastasis (OR = 1.76; 95% CI 1.14, 2.72; P = 0.01) in breast cancer. The stability and reliability of results in this meta-analysis were confirmed by sensitivity analysis. Conclusion Elevated PLR is related to a poor prognosis and a higher risk of LNM, advanced TNM stage, and distant metastasis in breast cancer patients. Therefore, PLR can be identified as a biomarker with potential prognostic value in breast cancer.

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Section: Resultsmentioning

confidence: 99%

“…Multivariate analysis was adopted in 19 studies. 19–38 The follow-up months ranged from 60 to 200 months in these studies, with NOS scores of 6–8 points (Table S1).…”

Section: Resultsmentioning

confidence: 99%

Platelet-to-lymphocyte ratio associated with the clinicopathological features and prognostic value of breast cancer: A meta-analysis

Gong

Xin²,

et al. 2022

Int J Biol Markers

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“…Recent studies on FBC have shown that patient-related inflammatory factors play a role in tumor initiation, formation, development, recurrence, metastasis, and treatment response. High NLR, PLR, and low LMR are reported as prognostic factors associated with survival 3,22,23 . In the study by Sun et al comparing HIP values of healthy and FBC patients, MPV, RDW, NLR, and PLR values were found higher in FBC patients 6 .…”

Section: Discussionmentioning

confidence: 99%

Hemogram index parameters in the evaluation of male breast cancer and inflammatory response: a case-control study

Dal

Ökmen

Ulusan

et al. 2022

Rev. Assoc. Med. Bras.

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OBJECTIVE: Our aim was to investigate the hemogram index parameters and their clinical significance in the evaluation of the inflammatory response of patients with male breast cancer, who are rarely observed in the literature. METHODS:In total, 22 (n=22) healthy male and 28 (n=28) male breast cancer patients without synchronous/metachronous tumors were included in this study. They were grouped as the healthy male control group (Group 1) and the male breast cancer patient group (Group 2). The male breast cancer was divided into two subgroups, namely, early stage [(stage: 0/I/II) (Group 2A)] and late stage [(stage: III/IV) (Group 2B)], and their hemogram index parameters were compared.RESULTS: A significant (p>0.05) increase was observed in neutrophil/lymphocyte ratio (NLR) and•platelet/lymphocyte ratio (PLR) values in the late stage (Group 2B: stage III/IV) compared to the early stage (Group 2A: stage 0/I/II) and healthy control (Group 1) groups. CONCLUSIONS:In male breast cancer patients, neutrophil/lymphocyte ratio and platelet/lymphocyte ratio values were significantly higher as the stage of cancer increased. These readily available simple tests can be used to evaluate the host's inflammatory response in male breast cancer.

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“…TNBC is an heterogenous and aggressive breast cancer defined by the absence of oestrogen receptor, progesterone receptor and HER2 47 . An elevated NLR is also associated with a poor response in patients submitted to radiotherapy or neo‐adjuvant chemotherapy treatments 48,49 . Even in patients with metastatic disease, the presence of lower NLR showed to be indicative of a better prognosis 50,51 …”

Section: Introductionmentioning

confidence: 99%

Neutrophil‐to‐lymphocyte ratio is an independent prognostic marker for feline mammary carcinomas

Petrucci¹,

Lobo

Queiroga

et al. 2021

Vet Comparative Oncology

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Blood leukocyte counts and respective derived ratios have been described as potential prognostic markers in several tumours in veterinary oncology. This study aimed to evaluate peripheral blood leukocyte subpopulations and neutrophil‐to‐lymphocyte ratio (NLR) as prognostic factors for feline mammary carcinomas (FMC). Medical records from cats diagnosed with FMC between 2017 to 2019 were reviewed. Cats were included if fully staged, classified as WHO stage I to III, and submitted to mastectomy. Cats were excluded if they had evidence of other diseases. Forty‐nine cats were included. The study endpoints were disease‐free interval (DFI) and tumour‐specific survival (TSS). The median DFI and TSS were 389 days and 528 days respectively. In the univariate analysis, higher values of total white blood cell count (WBC), neutrophil count (NEU) and NLR were identified as significant prognostic factors for both endpoints (P < .05). On the multivariate analysis, NLR remained an independent prognostic factor for TSS (P = .024). In the receiver operating characteristic curve analysis, the estimated cut‐off for WBC was 8.49 × 109/L (DFI and TSS); for NEU was 4.62 × 109/L (DFI) and 6.65 × 109/L (TSS) and for NLR was 2.46. These cut‐offs were significant prognostic factors for DFI and TSS (P < .05). NLR cut‐off remained an independent prognostic factor for both DFI (P = .032) and TSS (P = .043) in the multivariable analysis. Our results suggest that NLR, NEU, and WBC can be important non‐invasive presurgical prognostic markers, and that NLR is an independent prognostic marker for FMC. Prospective studies are warranted to validate its clinical use.

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<p>Predictive Value of Lymphocyte-Related Blood Parameters at the Time Point of Lymphocyte Nadir During Radiotherapy in Breast Cancer</p>

Cited by 7 publications

References 31 publications

Platelet-to-lymphocyte ratio associated with the clinicopathological features and prognostic value of breast cancer: A meta-analysis

Platelet-to-lymphocyte ratio associated with the clinicopathological features and prognostic value of breast cancer: A meta-analysis

Hemogram index parameters in the evaluation of male breast cancer and inflammatory response: a case-control study

Neutrophil‐to‐lymphocyte ratio is an independent prognostic marker for feline mammary carcinomas

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