&lt;p&gt;Preoperative Fibrinogen-Albumin Ratio Index (FARI) is a Reliable Prognosis and Chemoradiotherapy Sensitivity Predictor in Locally Advanced Rectal Cancer Patients Undergoing Radical Surgery Following Neoadjuvant Chemoradiotherapy&lt;/p&gt;

Lu, Siyi; Liu, Zhenzhen; Zhou, Xin; Wang, Bingyan; Li, Fēi; Ma, Yanpeng; Wang, Wendong; Ma, Junren; Wang, Yuxia; Wang, Hao; Fu, Wei

doi:10.2147/cmar.s273065

Cited by 18 publications

(22 citation statements)

References 58 publications

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“…However, NCRT may reduce the total circulating leukocytes and interfere with the in ammatory response of the host, limiting the application of leukocyte-based in ammation biomarkers to predict the prognosis of LARC patients who underwent NCRT [17]. Our previous ndings were consistent with this point of view [20]. The CFP scoring system is a combination of tumor markers (CEA), in ammatory factors (lymphocytes and brinogen), and nutritional factors (albumin).…”

Section: Discussionsupporting

confidence: 78%

“…The brinogen-toalbumin index (FARI) is considered an essential biomarker that re ects both systemic in ammatory status and nutritional status, and several studies have reported that FARI is closely related to the prognosis of various cancers, such as breast cancer [17], esophageal cancer [18], and gastric cancer [19]. Our previous ndings have shown similar results in LARC patients undergoing TME following NCRT, and we have found that FARI is associated with tumor response [20]. The prognostic nutritional index (PNI), based on the albumin level and lymphocyte count, is another widely used biomarker that combines in ammatory and nutritional parameters.…”

Section: Introductionsupporting

confidence: 73%

“…Therefore, the identi cation of a novel biomarker that could predict prognosis and tumor response is vital. Recently, studies have shown that CEA [7], FARI [20], and PNI [21] are practical predictors of survival and tumor response in LARC patients who underwent radical surgery after NCRT. Hence, we veri ed the prognostic role of these parameters and established a CFP scoring system.…”

Section: Discussionmentioning

confidence: 99%

“…Since CEA [7], FARI [20] and PNI [21] have all been found to serve as indicators of the prognosis and tumor response of LARC patients, we wanted to explore whether a combination of tumor, in ammation, and nutrition markers could more accurately predict patient prognosis and response. Hence, this study aimed to investigate the role of a novel CFP scoring system (a combination of CEA, FARI, and PNI) on the prognosis and chemoradiotherapy response of LARC patients undergoing radical surgery following NCRT.…”

Section: Introductionmentioning

confidence: 99%

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The Novel CFP Scoring System is a Reliable Marker in Predicting Response and Prognosis in Patients with Locally Advanced Rectal Cancer Undergoing Neoadjuvant Chemoradiotherapy

Liu

Wang

et al. 2020

Preprint

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Background: Preoperative tumor markers, inflammation, and nutritional status are considered important predictors of prognosis and tumor response in locally advanced rectal cancer (LARC) patients. This study aims to explore the prognostic value of carcinoembryonic antigen (CEA), the Fibrinogen-Albumin Ratio Index (FARI), the Prognostic Nutritional Index (PNI) and a combined scoring system in LARC patients.Methods: A total of 138 LARC patients undergoing radical surgery following neoadjuvant chemoradiotherapy (NCRT) between January 2012 and March 2019 were enrolled. The X-tile program was used to determine the optimal cutoff values of CEA, FARI, and PNI. A novel combined scoring system, CEA-FARI-PNI (CFP), was constructed. The prognostic ability of these factors was assessed by the time-dependent receiver operating characteristic (ROC) curve, Kaplan-Meier, Cox regression, and logistic regression. A nomogram was established to evaluate the predictive role of CFP in tumor response.Results: The optimal cutoff values of CEA, FARI, and PNI were 5.15 ng/l, 10.56%, and 42.25 g/L, respectively. The time-dependent ROC curve showed that compared to CEA, FARI, and PNI, CFP showed stable predictive efficacy for overall survival (OS) and disease-free survival (DFS). In multivariate analysis, CFP was the only factor that could independently predict OS (HR=8.117, p=0.001) and DFS (HR=4.994, p<0.001). Moreover, high CFP (OR=3.693, p=0.002) was also an independent risk factor of poor response. The area under the ROC curve (AUC) of the nomogram for predicting TRG (tumor regression grade) was better with CFP (0.717) than without (0.656) (p<0.05).Conclusions: The CFP score is an independent prognostic factor of OS, DFS, and tumor response in LARC patients. It might be a more reliable marker for predicting the prognosis of LARC patients.

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Section: Discussionsupporting

confidence: 78%

Section: Introductionsupporting

confidence: 73%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Novel CFP Scoring System is a Reliable Marker in Predicting Response and Prognosis in Patients with Locally Advanced Rectal Cancer Undergoing Neoadjuvant Chemoradiotherapy

Liu

Wang

et al. 2020

Preprint

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“…Their expression levels correlate with the therapeutic effects of radiotherapy and chemotherapy. 15 , 16 , 18 , 65 , 97–105 In recent years, an increasing number of scholars have highlighted the application value of FPR and FAR or AFR in colorectal cancer treatment. The detection of serum levels of FPR and FAR or AFR is not only suitable for CRC patients with AJCC diagnosed as being stage I–III but also for high-risk patients with metastasis.…”

Section: Application Of Fpr and Far Or Afr In Crcmentioning

confidence: 99%

Research Progress of Preoperative FPR, FAR or AFR in Patients with Colorectal Cancer

Chen¹,

Liu²,

Han³

et al. 2021

CMAR

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Research has confirmed that plasma albumin (Alb), prealbumin (PA) and fibrinogen (Fib) are involved in regulating the occurrence and development of various tumors. Their levels in peripheral blood are related to the survival outcome and treatment response of patients, but the accuracy and specificity of single application have yet to be fully realized. A growing amount of evidence indicates that predictors such as preoperative fibrinogen to prealbumin ratio (FPR), fibrinogen to albumin ratio (FAR) or albumin to fibrinogen ratio (AFR) are emerging as comprehensive indicators. Indeed, their components play a key regulatory role in the progression of colorectal cancer (CRC). Preoperative FPR, FAR or AFR levels, therefore, are expected to become new biomarkers for prognosis evaluation and curative effect prediction for CRC patients and are significant in the guidance they could provide for the development of individualized treatment strategies.

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Prognostic ability of the neoadjuvant rectal (NAR) score in long‐course concurrent chemoradiotherapy for patients with locally advanced rectal cancer: a retrospective cohort study

Peng

et al. 2023

Malignancy Spectrum

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BackgroundThe aims of this study were to evaluate the prognostic ability of the neoadjuvant rectal (NAR) score and to develop and validate a nomogram based on the NAR for patients with locally advanced rectal cancer (LARC) treated with neoadjuvant chemoradiotherapy (nCRT).MethodsIn total, 307 patients, including 230 patients from the primary cohort and 77 from the external cohort, were enrolled across the two centers. The associations of the NAR score with the tumor response, tumor control, and clinicopathological parameters were analyzed. Survival analysis was performed in the primary and external cohorts using Kaplan‒Meier curves. Univariate and multivariate analyses were performed to evaluate the prognostic factors. The NAR‐based nomogram was developed in the primary cohort and validated in the external cohort using the concordance index (C‐index), calibration plots, and decision curve analyses (DCAs).ResultsKaplan‒Meier survival analysis revealed that the disease‐free survival (DFS) and overall survival (OS) of the NAR > 16 group were significantly lower than those of the NAR ≤ 16 group (p < 0.001). Multivariate Cox regression analysis identified the NAR score as an independent prognostic factor for both DFS (hazard ratio [HR] = 2.484, 95% confidence interval [CI]: 1.159−5.323, p = 0.019) and OS (HR = 4.633, 95% CI: 1.076−19.941, p = 0.04). Calibration plots and DCAs showed that NAR‐based nomograms for DFS and OS were consistent and useful in clinical practice. Moreover, the C‐indexes of the NAR‐based nomograms were better than those of the other variables in both the primary and external cohorts.ConclusionOur study validates the prognostic role of the NAR score for DFS and OS. The NAR‐based nomogram for OS could accurately predict the outcome of LARC patients by stratifying the risk score accordingly.

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<p>Preoperative Fibrinogen-Albumin Ratio Index (FARI) is a Reliable Prognosis and Chemoradiotherapy Sensitivity Predictor in Locally Advanced Rectal Cancer Patients Undergoing Radical Surgery Following Neoadjuvant Chemoradiotherapy</p>

Cited by 18 publications

References 58 publications

The Novel CFP Scoring System is a Reliable Marker in Predicting Response and Prognosis in Patients with Locally Advanced Rectal Cancer Undergoing Neoadjuvant Chemoradiotherapy

The Novel CFP Scoring System is a Reliable Marker in Predicting Response and Prognosis in Patients with Locally Advanced Rectal Cancer Undergoing Neoadjuvant Chemoradiotherapy

Research Progress of Preoperative FPR, FAR or AFR in Patients with Colorectal Cancer

Prognostic ability of the neoadjuvant rectal (NAR) score in long‐course concurrent chemoradiotherapy for patients with locally advanced rectal cancer: a retrospective cohort study

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