&lt;p&gt;Prevalence and impact of risk factors for poor asthma outcomes in a large, specialist-managed patient cohort: a real-life study&lt;/p&gt;

Tomisa, Gábor; Horváth, Alpár; Szalai, Zsuzsanna; Müller, Veronika; Tamási, Lilla

doi:10.2147/jaa.s211246

Cited by 27 publications

(29 citation statements)

References 34 publications

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“…During the 1-year period of inclusion, an average of 69 patients were included per investigational site. This involved 187 centres, representing 35% of the pulmonologists currently working in outpatient medical clinics in Hungary [ 5 ].…”

Section: Resultsmentioning

confidence: 99%

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Epidemiology of comorbidities and their association with asthma control

Tomisa

Horváth

Santa³

et al. 2021

Allergy Asthma Clin Immunol

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Background The prevalence of comorbidities and their relation to asthma control and treatment is a topic of increasing interest, however comprehensive studies are scarce. We aimed to determine the prevalence of the most common comorbidities in asthma in relation to patient characteristics (age, gender and body mass index [BMI]) and their association with asthma control in a large, specialist-managed representative patient population. Methods A secondary, exploratory analysis of the Asthma Reality (ARL), across-sectional, non-interventional real-life study was conducted. Basic patient characteristics, the prevalence of comorbidities and data on asthma control and risk factors had been collected and their interactions examined. Descriptive statistics and binomial regression were used to assess the distribution of the prevalence of comorbidities and propensity matching was applied to assess their effect on asthma control. Results Overall, 12,743 patients were enrolled in our study in 187 treatment centres covering all regions of Hungary. Most comorbidities showed significantly different distribution for all basic patient characteristics. Gender, age group, smoking status, BMI and the duration of asthma had a significant impact on asthma control. The frequency of uncontrolled asthma was higher in females (37.1%), in the age group of 46–65 years (39.6%), in severely obese patients (43.2%), in patients who had been diagnosed with asthma for more than 20 years (40.4%), and in active heavy smokers (55%), compared with respective groups in the same category. Based on the binomial regression with propensity score matching, concomitant chronic obstructive pulmonary disease (COPD) (odds ratio [OR] = 2.06, 95% confidence interval [CI] 1.80–2.36), ischaemic heart disease (OR = 1.86, 95% CI 1.64–2.10) and cerebrovascular events (OR = 1.85, 95% CI 1.47–2.32) had the strongest negative effect on asthma control, with the presence of all of these conditions increasing the risk of uncontrolled asthma. Conclusions This evaluation of comorbidity data of more than 12,000, adult asthmatic patients has provided a clearer picture of diseases that can frequently co-exist with asthma, and their influence on asthma control, assessed by the prevalence of symptoms. Our study suggests that most asthmatic patients have at least one comorbidity, and the presence of comorbidities may have a high impact on asthma control measures.

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Section: Resultsmentioning

confidence: 99%

“…We previously reported in a large, real-world evidence study (Asthma Reality [ARL]), risk factors for poor asthma outcomes and poor adherence, have a considerable influence on the control level of asthmatic patients [ 5 ]. As part of the ARL study, data on comorbidities had been collected.…”

Section: Introductionmentioning

confidence: 99%

Epidemiology of comorbidities and their association with asthma control

Tomisa

Horváth

Santa³

et al. 2021

Allergy Asthma Clin Immunol

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“…Lastly, patients who smoke cigarette were found to have a higher probability of uncontrolled asthma. This is supported by different studies conducted in Saudi Arabia (15), England (43), Hungary (44), and Nigeria (18). This might be because smoking is signi cantly associated with the decline in lung function (45).…”

Section: Discussionmentioning

confidence: 60%

Determinants of Uncontrolled Asthma Among Adult Asthmatic Patients on Follow-Up at Chest Clinic of Jimma Medical Center: Unmatched Case-Control Study

Geleta

Dadi

Sona

2020

Preprint

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BackgroundUncontrolled asthma is a notorious public health problem throughout the world despite the presence of effective treatments. Characterizing phenotypes of patients with uncontrolled asthma and searching for risk factors of uncontrolled asthma have been suggested as priority research agenda in the prevention of chronic respiratory diseases. This study aimed to identify the determinants of uncontrolled asthma.MethodsInstitution-based case-control study was conducted on asthmatic patients who were on follow-up at chest clinic of Jimma University Medical (JMC) from March to May, 2020. A total of 59 cases and 118 controls were included in the study. Logistic regression was employed to identify determinants of uncontrolled asthma. Adjusted odds ratios (AORs) with their corresponding confidence intervals (CI) were used to assess the strengths of association between uncontrolled asthma and its determinants at p values ≤ 0.05.ResultsAge of the patients [AOR: 2.78; 95% CI: 1.14, 6.81], age of the cases’ residential houses [AOR: 3.65; 95% CI: 1.30, 10.28], presence of pets within the houses [AOR: 2.78; 95% CI: 1.29, 5.96], having rhinitis [AOR: 3.34; 95% CI: 1.17, 9.52], past asthma exacerbation [AOR: 2.38, 95% CI: 1.05, 5.40], non-adherence to treatment [AOR: 2.81; 95% CI: 1.30, 6.08] and smoking [AOR: 7.09; 95% CI: 1.84, 27.33] were found to be determinants of uncontrolled asthma.ConclusionsUncontrolled asthma is resulted from multiple sociodemographic, environmental, clinical, and behavioral factors. Therefore, interventions targeting to improve asthma control should consider those factors comprehensively.

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“…Annak ellenére, hogy jelentős részük érzékenyen reagál a dohányfüstre (ami az asztma patofiziológiájából is adódik), a bevont betegek 13,1%-a aktív dohányos volt, míg 20,3%-uk dohányzott a betegsége korábbi szakaszában. A dohányzás volt az elhízás mellett a leggyakrabban tapasztalt rizikófaktor a rossz kontroll tekintetében [20].…”

Section: Légzőrendszeri Hatások Copd Asztma éS Tüdőrákunclassified

A cigaretta, az elektromos cigaretta és a vízipipa egészségre gyakorolt hatása

Farkas

Tomisa²,

Kis

et al. 2021

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Összefoglaló. A dohányzás káros hatásainak vizsgálata hosszú ideje az orvostudomány egyik legintenzívebben kutatott területe. A nagy tudományos érdeklődésnek köszönhetően ma már meggyőző evidenciák állnak rendelkezésre a hagyományos cigaretta használatának számos negatív hatásáról. Ezzel ellentétben a sokkal később bevezetett helyettesítő termékek veszélyeiről lényegesen kevesebbet tudunk. E körbe tartozik a manapság egyre népszerűbb elektromos cigaretta is, amelyre egyre több, egészségügyi kockázatot felmérő munka fókuszál. Ugyanakkor a több évszázados múltra visszatekintő és a világ bizonyos helyein sokáig népszerű vízipipa érdekes esetnek számít, mivel használóinak száma a nyugati világban az utóbbi időben megugrott, de az emberre gyakorolt hatása számos ponton még vita tárgyát képezi. A jelen munka célja, hogy a hazai és a nemzetközi szakirodalom alapján feltérképezze a hagyományos cigaretta, az elektromos cigaretta és a vízipipa fontosabb egészségügyi hatásait, és rámutasson azokra a kapcsolódó területekre, ahol további kutatások szükségesek. A szakirodalmi áttekintés során a különböző publikációs adatbázisokban fellelhető tudományos cikkeket elemeztük. A megvizsgált szakirodalom alapján a tartós dohányzásnak bizonyítottan a szív-ér rendszert és a légzőrendszert károsító hatása van, de növekvő számú bizonyíték utal a neurológiai káros hatásokra és a gasztroenterológiai hatásokra is. Ugyanakkor az elektromos cigaretta és a vízipipa esetében a bizonyított akut hatások mellett a hosszú távú hatásokat illetően további intenzív kutatásokra van szükség. Az elektromos cigaretta és a vízipipa esetében a hosszú távú hatások kapcsán a meggyőző evidencia hiánya semmiképpen nem jelenti azt, hogy ezen termékeket kockázatmentesnek kellene tekinteni, sőt a pulmonológusoknak és a döntéshozóknak mindent meg kell tenniük annak érdekében, hogy valamennyi dohánytermék törvényi szabályozása azok használatának visszaszorítását célozza. A kérdés fontosságának a COVID–19-pandémia különös aktualitást ad. Orv Hetil. 2021; 162(3): 83–90. Summary. Revealing the health effects associated with smoking has been in the focus of intense research for decades. Due to these research efforts, there is a convincing evidence regarding the negative effects of conventional cigarettes. However, much less is known about the replacement products such as electronic cigarettes. Moreover, the effects of waterpipes are also not fully explored, in spite of their long history. The scope of the present work is to survey the open literature to map the knowledge related to the health effects of conventional cigarettes, e-cigarettes and waterpipes. The analysis of the related scientific literature was performed based on papers retrieved in large publication repositories. Based on the reviewed literature, long-term smoking has demonstrated adverse effects on the respiratory as well as the heart and circulatory systems. In addition, the correlation between cigarette smoking and some gastroenterological and neurological diseases is also increasingly evident. By the same token, though the acute effects of e-cigarette and waterpipe are well documented, the protracted effects are still to be explored. The lack of pertinent information regarding the late effects of e-cigarette and hookah does not imply that there is no health risk associated with their consumption. On the contrary, in addition to the regular antismoke measures, pulmonologists and policy makers should do everything to lower the consumption of these alternative products. Orv Hetil. 2021; 162(3): 83–90.

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<p>Prevalence and impact of risk factors for poor asthma outcomes in a large, specialist-managed patient cohort: a real-life study</p>

Cited by 27 publications

References 34 publications

Epidemiology of comorbidities and their association with asthma control

Epidemiology of comorbidities and their association with asthma control

Determinants of Uncontrolled Asthma Among Adult Asthmatic Patients on Follow-Up at Chest Clinic of Jimma Medical Center: Unmatched Case-Control Study

A cigaretta, az elektromos cigaretta és a vízipipa egészségre gyakorolt hatása

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