&lt;p&gt;Prevalence, Clinical Characteristics, and Risk Among Patients with Ischemic Heart Disease in the Young Jordanian Population&lt;/p&gt;

Raffee, Liqaa; Alawneh, Khaled; Ibdah, Rasheed; Rawashdeh, Sukaina I.; Zoghoul, Sohaib; Ewais, Abdel Salam; Al-Mistarehi, Abdel-Hameed

doi:10.2147/oaem.s272961

Cited by 15 publications

(9 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

Section: Discussionmentioning

confidence: 99%

“…27 These findings are alarming, and it is already being reported that there is a high prevalence of ischemic heart disease (IHD) in young Jordanian adults, and two significantly associated factors with IHD are smoking and hypertension. 28 Participants who were found to have high blood pressure readings during any of the visits were advised to start lifestyle modifications and to follow with the primary care clinics.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Prevalence of Undiagnosed Hypertension and Its Predictors in Jordan: A Cross-Sectional Study

Alhawari¹,

Alshelleh²,

Alhawari³

et al. 2022

IJGM

View full text Add to dashboard Cite

Introduction Hypertension is an important cause of morbidity and mortality worldwide. Undiagnosed hypertension is a serious issue that leads to increased morbidity and mortality. In this study, we aim to identify the prevalence of undiagnosed hypertension in the healthy Jordanian population, as well as identify predictors of high blood pressure readings in presumably healthy Jordanians. Materials and Methods We recruited healthy visitors accompanying patients at our Jordan University Hospital Clinics ranging from 18 to 80 years of age. We measured each participant’s systolic and diastolic blood pressure at our outpatient clinics on two different days, one week apart. We also obtained demographic data, weight, height, smoking status, and family history of hypertension and cardiovascular diseases. Results A total of 896 participants were included in this study with a mean age of 48 years. The median of systolic blood pressure readings was 125 mmHg, and the median of diastolic blood pressure readings was 83 mmHg. 38.5% had undiagnosed stage 1 hypertension and 30.5% had undiagnosed stage 2 hypertension according to the American College of Cardiology/American Heart Association guidelines. On the other hand, 25.4% had undiagnosed grade 1 hypertension and 5.1% had undiagnosed grade 2 hypertension according to the European Society of Hypertension guidelines. Conclusion According to the ACC/AHA guidelines, 68.5% of previously healthy Jordanians met the criteria to be diagnosed with hypertension. Predictors of high systolic blood pressure were age, BMI and family history of CAD, while female gender is associated with a lower systolic blood pressure. For diastolic blood pressure, only BMI and family history of CAD were associated with significantly higher diastolic blood pressure, while female gender and exercise were significantly associated with lower diastolic blood pressure.

show abstract

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Prevalence of Undiagnosed Hypertension and Its Predictors in Jordan: A Cross-Sectional Study

Alhawari¹,

Alshelleh²,

Alhawari³

et al. 2022

IJGM

View full text Add to dashboard Cite

show abstract

“…2 Non-communicable diseases (NCDs) such as cardiovascular diseases (CVD) are highly prevalent and considered the leading cause of death in developing countries. 6,7 Dyslipidemia significantly contributes to CVD, T2DM and atherosclerosis development. [2][3][4] Even mild lipid profile abnormalities may increase the risk of CAD significantly in the presence of other CAD risk factors such as T2DM.…”

Section: Introductionmentioning

confidence: 99%

Prevalence and Pattern of Dyslipidemia and Its Associated Factors Among Patients with Type 2 Diabetes Mellitus in Jordan: A Cross-Sectional Study

Quran¹,

Bataineh²,

Al-Mistarehi³

et al. 2022

IJGM

Self Cite

View full text Add to dashboard Cite

Background Dyslipidemia and type 2 diabetes mellitus (T2DM) are growing health problems, particularly in developing countries. This study aimed to determine the prevalence and pattern of dyslipidemia and its associated factors among patients with T2DM. Methods A cross-sectional study was conducted among patients with T2DM attending Family Medicine Clinics in Jordan between August 2017 and March 2019. The socio-demographics, clinical features, medications, and laboratory findings were collected. These laboratory findings included high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), and triglycerides (TGs). Results A total of 870 patients with T2DM were included. The prevalence of dyslipidemia among patients with T2DM was 91.4%. The most common patterns of dyslipidemia were low HDL-C (66.2%), high LDL-C (62.1%), and hypertriglyceridemia (58.2%). Female gender, obesity, and hypertension were associated with diabetic dyslipidemia patterns. T2DM duration and poor glycemic control were associated with high LDL-C and hypercholesterolemia. Hypertriglyceridemia was associated with poor glycemic control and smoking. Conclusion Dyslipidemia is highly prevalent among patients with T2DM. Evidence –based interventions are needed to prevent and control dyslipidemia among patients with T2DM in Jordan.

show abstract

“…Застосування карнітин-аргінінової суміші обґрунтовували тим, що L-карнітин є одним із відомих кардіометаболічних препаратів з широким спектром дії [7], який відіграє важливу роль в енергетичному обміні у міокарді за рахунок транспортування і β-окислення ненасичених жирних кислот в мітохондріях [8,9], позитивно впливає на скоротливу функцію міокарда [10,11,12], а L-аргінін є субстратом для синтезу оксиду азоту (NO) в ендотеліоцитах, зниження біодоступністі якого (NO) часто спостерігається при цукровому діабеті, ожирінні та артеріальній гіпертензії.…”

unclassified

Correction of Insulin Resistance in Obese Patients With Myocardial Infarction and Comorbid Metabolic Syndrome

Швед

2022

Scientific and practical journal

View full text Add to dashboard Cite

Objective. Insulin resistance (IR) is playing an essential role in the development of cardiovascular disease and has an adverse prognostic effect on the course of acute myocardial infarction (AMI) as a result of direct proatherogenic effects of IR and an adverse effect on myocardial contractility. The aim of the study was to evaluate the insulin resistance effects of multimodality therapy with dapagliflozin (Forxiga) and L-arginine/L-carnitine combination in overweight and obese patients with myocardial infarction. The aim of the study: to evaluate the insulin resistance effects of multimodality therapy with dapagliflozin (Forxiga) and L-arginine/L-carnitine combination in overweight and obese patients with myocardial infarction. Methods. The study enrolled 85 males with acute myocardial infarction with ST segment elevation; among these, there were 24 overweight patients (BMI within 25–29.9 kg/m2) and 36 patients with obesity (BMI >30 kg/m2). Normal body weight (BMI within 18–24.9 kg/m2) was documented in 25 study patients. The age of study subjects in the groups was 58.62±7.02 years on average. All patients were receiving standard of care treatment according to the protocols of the MoH of Ukraine [8]. Depending on the treatment program used, all patients were divided into three groups: Group 1 enrolled 25 patients who were receiving standard of care per-protocol treatment; Group 2 (test group) enrolled 28 patients where standard of care per-protocol treatment of MI was appended with L-arginine/L-carnitine combination (“TIVOR-L” by Yuria-Pharm Ltd.; marketing authorization No. UA/15067/01/01) as intravenous infusions for seven days at 100.0 ml once a day; Group 3 (test group) enrolled 32 patients who received dapagliflozin (10 mg/day) in addition to combination therapy (per-protocol treatment + L-arginine/L-carnitine combination). Control group enrolled 20 virtually healthy volunteers without cardiovascular disease. The presence of IR was assessed using HOMA-IR index. The severity of IR was determined based on the magnitude of the IR factor according to F. Caro. The patients were considered to have IR if the following criteria were met: HOMA > 2.77 and Caro index < 0.33; i.e. the higher the HOMA index and the lower the Caro index, the lower was the tissue sensitivity to insulin and the greater was the IR. Statistical analysis of study findings was performed using Statistica 10.0 package of statistical software and Microsoft Excel 2019. Results. Overweight and obese patients with MI + MS develop carbohydrate metabolism disorders, which are manifested by hyperglycemia, increased HOMA index and decreased Caro index. Insulin resistance is the main cause of the above disorders. The severity of insulin resistance was increasing in the presence of excessive body and obesity, as suggested by a significant reduction in Caro index. It is the presence of IR and carbohydrate metabolism disorders that contributed to the development of systolic-diastolic dysfunction of the myocardium in patients with ACS (MI). Conclusions. At baseline, overweight and obese patients with myocardial infarction develop a pronounced insulin resistance with carbohydrate metabolism disorders and reduced systolic-diastolic function of the heart. Multi-modality treatment with inclusion of L-carnitine/L-arginine combination and dapagliflozin in overweight and obese patients with myocardial infarction facilitated restoration of tissue sensitivity to insulin and improved carbohydrate metabolism and systolic-diastolic function of the heart in such comorbid patients.

show abstract

<p>Prevalence, Clinical Characteristics, and Risk Among Patients with Ischemic Heart Disease in the Young Jordanian Population</p>

Cited by 15 publications

References 24 publications

Prevalence of Undiagnosed Hypertension and Its Predictors in Jordan: A Cross-Sectional Study

Prevalence of Undiagnosed Hypertension and Its Predictors in Jordan: A Cross-Sectional Study

Prevalence and Pattern of Dyslipidemia and Its Associated Factors Among Patients with Type 2 Diabetes Mellitus in Jordan: A Cross-Sectional Study

Correction of Insulin Resistance in Obese Patients With Myocardial Infarction and Comorbid Metabolic Syndrome

Contact Info

Product

Resources

About