&lt;p&gt;Prevalence, Predictors and Treatment Outcome of Acute Poisoning in Western Ethiopia&lt;/p&gt;

Tefera, Gosaye Mekonen; Teferi, Lema Getachew

doi:10.2147/oaem.s277269

Cited by 16 publications

(19 citation statements)

References 33 publications

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“…The finding contradicts the studies conducted in Turkey, Ethiopia, and Eastern Nepal which reported no significant association between mode of poisoning and poor treatment outcome of acute poisoning. 4,7,12,13,39 In the current study, the odds of having poor treatment outcome in participants who were poisoned by drugs was 2.13 time more likely than non-drugs poisoning. Improving rational use of drugs and counseling the patients in their drugs would decrease the number of severe acute poisoning cases.…”

Section: Poisoning (N) Antidote(n)mentioning

confidence: 56%

“…Other studies revealed similar results. 4 , 19 – 22 This could be due to increased levels of stress on an individual with exposure to different social, economical, and occupational pressure. 23 The finding of the current study showed that acute poisoning was higher in females (57.3%) than males, which is comparable to other study results.…”

Section: Discussionmentioning

confidence: 99%

“…A data abstraction format adapted from different literature, 4,7,10,12,13 was used to record the necessary information from patients’ medical records. The data abstraction format was prepared in English language and included variables like sex of patients, age of patients, residence, route of poisoning, type of poisoning, clinical presentations, the status of patients when coming to the hospital, reason of patients for taking the poison, time of arrival to the emergency of the hospital, source of poisoning agents, length of hospital stay, treatment given for the acute poisoning, and treatment outcome.…”

Section: Methodsmentioning

confidence: 99%

“…3 In Ethiopia, evidence from hospital-based studies revealed that acute poisoning is common and an important clinical emergency with a varying case fatality rate, ranging from 1.5% to 18.6%. 4 – 11…”

Section: Introductionmentioning

confidence: 99%

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Treatment outcome and associated factors among patients admitted with acute poisoning in a tertiary hospital in Eastern Ethiopia: A cross-sectional study

et al. 2022

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Introduction: Acute poisoning causes morbidity and mortality worldwide. There is scarce of information on acute poisoning in the study area. Objective: To assess treatment outcome and the associated factors among patients admitted with acute poisoning at Hiwot Fana Comprehensive Specialized Hospital, Eastern Ethiopia. Methods: A cross-sectional study was conducted. All acutely poisoned patients who had been admitted at the emergency department of Hiwot Fana Comprehensive Specialized Hospital from 1 January 2016 to 31 December 2020 who fulfilled the inclusion criteria of the study were included. Data were collected by review of medical records. Poor treatment outcome of acute poisoning was defined as the acutely poisoned patient was died, or survived with disability. Multivariate logistic regression analysis was used to determine factors associated with the outcome of acute poisoning. Result: A total of 175 patient’s medical records were reviewed. Of these, 150 patient’s medical records had complete information and were included in the final analysis. The majority of participants 89 (59.3%) were in the age group of 19–37 years. More than half of the participants 86 (57.3%) were females. Organophosphate was the most poisoning agent encountered in 62 cases. Acetaminophen was the predominant drug poisoning agent encountered in 10 participants. Among 30 patients managed with antidote, 18 patients were treated with atropine for organophosphate poisoning. Of all the poisoning cases admitted during the study period, 16.7% died. Participants who were poisoned by themselves were 2.4 times more likely to have poor treatment outcomes than those who were poisoned accidentally: 2.44 (95% confidence interval: 1.10–5.42). The odd of having poor treatment outcome in participants who were poisoned by drugs was 2.13 more likely: 2.13 (95% confidence interval: 1.21–3.32). Conclusion: Organophosphate was the predominant cause of acute poisoning encountered in 62 cases. The modes of poisoning and drug poisoning were significant risk factors associated with poor treatment outcomes of acute poisoning.

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Section: Poisoning (N) Antidote(n)mentioning

confidence: 56%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Treatment outcome and associated factors among patients admitted with acute poisoning in a tertiary hospital in Eastern Ethiopia: A cross-sectional study

et al. 2022

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“…Acute poisoning is defined as exposure to poison within 24 hours through any route, intentionally or unintentionally [ 1 ]. Pediatric poisoning poses significant morbidity and mortality to a country and is one of the reasons for presentation to an emergency department.…”

Section: Introductionmentioning

confidence: 99%

A Descriptive Study of Acute Pediatric Poisoning Age 0–12 Years Old Presenting to Pediatric Emergency Department Hospital Tunku Azizah, Malaysia

Ong¹

2023

Cureus

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Introduction: Acute pediatric poisoning poses significant morbidity and mortality to a country. This study looks at the pattern of acute pediatric poisoning in ages 0-12 years old presenting to a pediatric emergency department in a tertiary hospital in Kuala Lumpur.Method: We performed a retrospective review of acute pediatric poisoning aged 0-12 years old presenting to the pediatric emergency department of Hospital Tunku Azizah Kuala Lumpur from 1st January 2021 to 30th June 2022.Results: A total of 90 patients were included in this study. The ratio of female to male patients was 2:3. Oral ingestion was the most common route of poisoning. 73% of patients were from 0-5 years old and primarily asymptomatic. Pharmaceutical agents were the most common agent of poisoning-no mortality in this study. Conclusion:The prognosis of acute pediatric poisoning was good in the 18 months of the study period.

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Accuracy of Rapid Emergency Medicine Score and Sequential Organ Failure Assessment Score in predicting acute paraphenylenediamine poisoning adverse outcomes

El-Sarnagawy

Ghonem

Abdelhameid

et al. 2022

Environ Sci Pollut Res

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Paraphenylenediamine (PPD) is a commonly used xenobiotic in hair dying, causing deleterious outcomes in acute poisoning. Although many epidemiological studies and case reports explained their clinical presentations and fatal consequences, no studies have evaluated the early determinants of adverse outcomes. Therefore, the present study aimed to assess the initial predictors of acute PPD poisoning adverse outcomes, focusing on the discriminatory accuracy of the Rapid Emergency Medicine Score (REMS) and Sequential Organ Failure Assessment (SOFA) score. A retrospective cohort study included all acute PPD-poisoned patients admitted to three Egyptian emergency hospitals from January 2020 to January 2022. Data was gathered on admission, including demographics, toxicological, clinical, scoring systems, and laboratory investigations. Patients were categorized according to their outcomes (mortality and complications). Ninety-seven patients with acute PPD poisoning were included, with a median age of 23 years, female predominance (60.8%), and suicidal intention (95.9%). Out of all patients, 25.77% died, and 43.29% had complicated outcomes. Respiratory failure was the primary cause of fatalities (10.30%), while acute renal failure (38.14%) was a chief cause of complications. The delay time till hospitalization, abnormal electrocardiogram, initial creatine phosphokinase, bicarbonate level, REMS, and SOFA scores were the significant determinants for adverse outcomes. The REMS exhibited the highest odds ratio (OR = 1.91 [95% confidence interval (CI): 1.41–2.60], p < 0.001) and had the best discriminatory power with the area under the curve (AUC) = 0.918 and overall accuracy of 91.8% in predicting mortality. However, the SOFA score had the highest odds ratio (OR = 4.97 [95% CI: 1.16–21.21], p = 0.001) and only yielded a significant prediction for complicated sequels with AUC = 0.913 and overall accuracy of 84.7%. The REMS is a simple clinical score that accurately predicts mortality, whereas the SOFA score is more practicable for anticipating complications in acute PPD-poisoned patients.

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<p>Prevalence, Predictors and Treatment Outcome of Acute Poisoning in Western Ethiopia</p>

Cited by 16 publications

References 33 publications

Treatment outcome and associated factors among patients admitted with acute poisoning in a tertiary hospital in Eastern Ethiopia: A cross-sectional study

Treatment outcome and associated factors among patients admitted with acute poisoning in a tertiary hospital in Eastern Ethiopia: A cross-sectional study

A Descriptive Study of Acute Pediatric Poisoning Age 0–12 Years Old Presenting to Pediatric Emergency Department Hospital Tunku Azizah, Malaysia

Accuracy of Rapid Emergency Medicine Score and Sequential Organ Failure Assessment Score in predicting acute paraphenylenediamine poisoning adverse outcomes

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