&lt;p&gt;Prognostic Values of Radiosensitivity Genes and CD19 Status in Gastric Cancer: A Retrospective Study Using TCGA Database&lt;/p&gt;

Liu, Liang; Huang, Xinyan; He, He; Liu, Jiyan

doi:10.2147/pgpm.s265121

Cited by 7 publications

(5 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nevertheless, these studies collectively con rmed that NPC patients with high CD19 + B lymphocytes had a better survival rate. In addition, previous studies have reported that B lymphocytes are associated with better survival when observed in gastric cancer and head and neck cancer (Liang et al 2020;Pretscher et al 2009;Yu et al 2012).…”

Section: Discussionmentioning

confidence: 94%

WITHDRAWN: Prognostic significance of circulating lymphocyte subsets in patients with nasopharyngeal carcinoma

Shen

Yan

Lan

et al. 2021

Preprint

View full text Add to dashboard Cite

Objective The purpose of this study was to explore the prognostic value of circulating lymphocyte subsets in patients with nasopharyngeal carcinoma (NPC) before treatment and the impact of chemoradiotherapy on lymphocyte subsets. Methods 934 patients with non-metastatic nasopharyngeal carcinoma were analyzed retrospectively. The percentage of circulating lymphocyte subsets was detected by flow cytometry and analyzed retrospectively. The correlation between lymphocyte subsets and prognosis was evaluated by the log-rank test and Cox proportional hazards model, and the differences of lymphocyte subsets before and after chemoradiotherapy was comparing by the paired t-test and Wilcoxon signed rank test. Results Univariate and multivariate analyses indicated that high CD19+ B lymphocytes (HR 0.705, 95%CI 0.519–0.958, P = 0.026) and CD4+ T lymphocytes (HR 0.560, 95%CI 0.331–0.946, P = 0.030) before treatment were independent favorable prognostic factors for overall survival (OS) and distant metastasis-free survival (DMFS) in NPC patients, respectively. After chemoradiotherapy, the percentage of CD3+ T lymphocytes, CD4+ T lymphocytes, CD4/CD8 ratio and CD19+ B lymphocytes decreased significantly, while the percentage of CD8+ T lymphocytes and NK lymphocytes increased significantly. Conclusion Patients with high CD19+B lymphocytes and CD4+T lymphocytes have a better prognosis, and perhaps the immune response can be improved to make the prognosis better by increasing the number of lymphocyte subsets. Chemoradiotherapy may reduce the immune function of patients with nasopharyngeal carcinoma.

show abstract

Section: Discussionmentioning

confidence: 94%

WITHDRAWN: Prognostic significance of circulating lymphocyte subsets in patients with nasopharyngeal carcinoma

Shen

Yan

Lan

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…For example, Capnocytophaga and Helicobacter were only found in the ESCA and STAD cohorts. It is known that Helicobacter pylori is a major etiological factor in the development of upper GI tract conditions (34), and its infection in the stomach is a risk factor for STAD prognosis (35). On the contrary, Faecalibacterium was found only in CRC samples.…”

Section: Several Studies Have Recently Characterized the Profile Of Tissue-mentioning

confidence: 99%

Global Analysis of Microbiota Signatures in Four Major Types of Gastrointestinal Cancer

Wang

et al. 2021

Front. Oncol.

View full text Add to dashboard Cite

The gut microbiota has been previously linked with tumorigenesis and gastrointestinal cancer progression; however, intra-tumor microbiota analysis has just emerged and deserves increasing attention. Based on the public databases of The Cancer Microbiome Atlas (TCMA) and The Cancer Genome Atlas (TCGA), this study identified the tissue/organ microbial signatures generated from 443 biosamples of four major gastrointestinal cancer types, including esophageal carcinoma (ESCA), which further includes esophageal adenocarcinoma (EAD) and esophageal squamous cell carcinoma (ESCC), stomach adenocarcinoma (STAD), colon adenocarcinoma (COAD), and rectum adenocarcinoma (READ). According to partial least squares discrimination analysis (PLS-DA), the profile differences in microbial communities between the tumor and normal samples were not particularly noticeable across the four cancer cohorts, whereas paired comparison analyses revealed several specific differences in bacteria between tumor and normal samples in the EAD, STAD, and COAD samples. The taxa classified from the phylum to genus level revealed a trend of distinguishable microbial profiles between upper and lower gastrointestinal tumors. The Bacteroidetes/Firmicutes ratio in lower gastrointestinal tract tumors was nearly three times that in upper gastrointestinal tract tumors. We also determined the relative tissue/organ-prevalent microbes for each of the four cohorts at the order and genus levels. Microbe Alistipes, Blautia, Pasteurellales, and Porphyromonas compositions were correlated with the clinical characteristics of patients with gastrointestinal cancer, particularly colorectal cancer. Taken together, our findings indicate that microbial profiles shift across different gastrointestinal cancer types and that microbial colonization is highly site-specific. Composition of specific microbes can be indicative of cancer stage or disease progression. Overall, this study indicates that the microbial community and abundance in human tissues can be determined using publicly available data, and provides a new perspective for intra-tissue/organ microbiota research.

show abstract

“… 2 , 3 Though some risk factors for STAD have been established, the molecular mechanism of the occurrence and progression of STAD is still far from clear. 4 Moreover, the therapeutic measures for STAD are limited and the prognosis for STAD patients are poor, with the overall survival rate of STAD patients in advanced stage of only approximately 12 months. 5 These alarming data suggested the urgent need of new prognostic biomarkers and therapeutic targets for STAD patients.…”

Section: Introductionmentioning

confidence: 99%

Comprehensive Analysis of the Prognostic Value and Immune Function of Immune Checkpoints in Stomach Adenocarcinoma

Shen¹,

Liu²

2021

IJGM

View full text Add to dashboard Cite

Background Stomach adenocarcinoma (STAD) is one of the most prevalent malignances and ranks fifth in incidence and third in the cancer-related deaths among all malignances. The prognosis of STAD is poor. Immunotherapy based on immune checkpoint blockade is ever-increasingly suggested as the most promising therapy strategy for STAD. However, the prognosis and therapy value of immune checkpoints in STAD is far from clarified. Methods In our study, bioinformatics methods were performed to explore the expression and prognosis value of immune checkpoints in STAD and their association with immune infiltration. qRT-PCR was performed to verify our result. Results Most of the immune checkpoints were upregulated in STAD. There were lots of genetic mutations among immune checkpoints in STAD, including missense_mutation, frame_shift_del et al. Interestingly, most of immune checkpoints were associated with drug sensitivity and drug resistance. Moreover, CD274, PVR, LGALS9, ICOSLG and CD70 were associated with the overall survival, post progression survival and first progression in STAD. The univariate and multivariate analysis revealed that CD70, ICOSLG, age, pTNM stage, and radiation therapy were independent factors affecting the prognosis of STAD patients. The expression of ICOSLG and CD70 was correlated with immune cells as well as immune biomarkers, including CD8+ T cells, CD4+ T cells, macrophage, neutrophils and dendritic cells. Conclusion All in all, our study performed a comprehensive analysis of the prognostic value and immune function of immune checkpoints in STAD, and our result suggested that immune checkpoint ICOSLG and CD70 serve as prognostic biomarkers and associate with immune infiltration in STAD.

show abstract

<p>Prognostic Values of Radiosensitivity Genes and CD19 Status in Gastric Cancer: A Retrospective Study Using TCGA Database</p>

Cited by 7 publications

References 30 publications

WITHDRAWN: Prognostic significance of circulating lymphocyte subsets in patients with nasopharyngeal carcinoma

WITHDRAWN: Prognostic significance of circulating lymphocyte subsets in patients with nasopharyngeal carcinoma

Global Analysis of Microbiota Signatures in Four Major Types of Gastrointestinal Cancer

Comprehensive Analysis of the Prognostic Value and Immune Function of Immune Checkpoints in Stomach Adenocarcinoma

Contact Info

Product

Resources

About