<p>Protective Effects of Curcumin and its Nano-Phytosome on Carrageenan-Induced Inflammation in Mice Model: Behavioral and Biochemical Responses</p>

Abstract

Background and purpose: Natural compounds are used for prevention of inflammation. Curcumin has antioxidant and anti-inflammatory properties, and loading it into nano-phytosomes may improve its efficiency. The present study investigates the effects of curcumin and its nanophytosome on behavioral and biochemical responses in carrageenan-induced inflammation in the mice model. Methods: The mice were divided into six groups and received oral administration of curcumin or its nano-phytosome at a dose of 15 mg/kg for seven days before the administration of carrageenan. Acute inflammation in the mice was induced by administration of carrageenan (1%) into the subplantar region of the left paw. Antioxidant activity and behavioral responses were then evaluated. Results: The results showed that the serum concentrations of antioxidant enzymes were significantly higher in the sal+sal group compared to the cara+sal group (P<0.05). Using nanophytosome, separately and in combination with indomethacin, increased the levels of antioxidant enzymes compared to the cara+sal group (P<0.05). Latency was significantly lower in the cara+sal group compared to the cara+sal group (P<0.05), but it was considerably higher in other groups, especially in the cara+nano.ph.cur+indo group (P<0.05). Conclusion: It can be stated that the nano-phytosome of curcumin could improve antioxidant and behavioral responses in inflamed mice.

Liposome Extract of Stachys pilifera Benth Effectively Improved Liver Damage due to Bile Duct Ligation Rats

“…Nanophytosomes protect Oxidative Medicine and Cellular Longevity curcumin and enhance its absorption. Curcumin nanophytosomes probably enhance the action of antioxidant enzymes and/or reduce oxidative stress [40]. In another study, Tan et al examined the antioxidant activity of carotenoids encapsulated in liposome delivery vehicles, and their results showed that encapsulation could improve radical inhibitory activity of carotenoids [41].…”

Phytosomes as Innovative Delivery Systems for Phytochemicals: A Comprehensive Review of Literature

“…The nano-phytosome treatment was more antioxidant than curcumin (P < 0.05) in the case of SOD, CAT, GPx, and GR and had a higher latency time compared to curcumin in hot plate and tail-pinch tests. 247 Three studies evaluated the topical effects of three different phytosomes in carrageenan-induced edema in Wistar rats. The Lawsone-containing phytosome complex (Lawsonia inermis L.) had a higher anti-inflammatory effect than plant extract gel at 4 h (P < 0.001).…”

“…The nano-phytosome treatment was more antioxidant than curcumin (P < 0.05) in the case of SOD, CAT, GPx, and GR and had a higher latency time compared to curcumin in hot plate and tail-pinch tests. 247 …”

Modulation of psoriatic-like skin inflammation by traditional Indian medicine Divya-Kayakalp-Vati and Oil through attenuation of pro-inflammatory cytokines

“… 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 Phytochemicals such as Berberine, and Curcumin present in DKV-O have individually shown efficacy to reduce carrageenan and TPA stimulated inflammation in animal models through the modulation of the cytokines, nitric oxides, cyclooxygenase and prostaglandins. 40 , 63 , 64 , 65 , 66 Furthermore, both Berberine and Curcumin have been observed to modulated the IL-17 and IL-23 expression in the immune cells. 67 , 68 , 69 …”