<p>Recurrent Molar in Five Consecutive Pregnancies – A Case Report</p>

Abstract

Recurrent molar pregnancy is very rare. In this case report, we highlight a case of a patient who experienced five recurrent molar pregnancies without an intervening normal pregnancy. A 22-year-old patient was admitted to our labour room with a fifth consecutive molar pregnancy. The patient underwent suction and evacuation and was followed up with serial serum human chorionic gonadotropin (beta-hCG) estimation. The patient did not require chemotherapy. Karyotype of the patient and her husband was normal. Nonetheless, the couple was counselled for adoption.

Decoding the Genetics of Recurrent Molar Pregnancy

“…The incidence of molar pregnancy varies according to a geographical area with incidence ranging from 1 to 160 pregnancies in India and the Middle East and 1 in 1500 pregnancies in the Western world. [ 1 ]…”

“…Recurrent molar pregnancy is extremely rare with the risk of repeat molar pregnancy after one complete H. mole to be 1.5% which increases to 25% after two molar pregnancies. [ 1 ] Recurrent complete molar pregnancies are extremely rare occurrences; they can be sporadic or be associated with a family history, with only 30 such families being reported in the literature. Women with such mutations have a major risk of reproductive failure and normal pregnancy is seen in only 1.8%.…”

Recurrent Hydatiform Mole, Clinical Features and Reproductive Outcome

“…Following a complete and partial molar pregnancy, the risk of HM in the following pregnancy has been reported as 0.91 and 0.28 percent, respectively. After two consecutive molar pregnancies, the risk increases to 23 percent [1] .…”