<p>Reduced Intellectual Ability in Offspring Born from Preeclamptic Mothers: A Prospective Cohort Study</p>

Abstract

Background: Severe preeclampsia may affect placental development, and high homocysteine (Hcy) levels are linked to intellectual disability. However, the correlation between perinatal Hcy levels and intellectual ability remains unknown in severe preeclampsia-affected offspring. Objective: We aimed to investigate the intellectual ability in offspring born from preeclamptic mothers and examine the role of prenatal Hcy in the prediction of intellectual disability in preschool-aged offspring. Methods: The IQ scores were compared between 101 children born to mothers with severe preeclampsia and 202 offsprings born to normotensive mothers. Maternal Hcy levels within 7 days prior to delivery and postnatal cord blood Hcy were measured. The associations of Hcy with IQ scores were evaluated, and the optimal cutoff values for predicting intellectual disability in the offspring were estimated. Results: The children born to mothers with severe preeclampsia had a greater postnatal cord blood Hcy than those born from normotensive mothers (P < 0.001), and the mothers with severe preeclampsia presented a higher prenatal Hcy (P < 0.001). The children born to mothers with severe preeclampsia had significantly lower IQ scores than those born from normotensive mothers, and a higher Hcy was associated with a lower IQ in preeclampsiaaffected offspring. The prevalence of intellectual disability was 2.86 times higher in severe preeclampsia-affected offspring than in children born from normotensive mothers, and the prevalence of low IQ was greater in children born to mothers with severe preeclampsia than in those from normotensive mothers. ROC curve analysis showed that both maternal and cord blood Hcy were predictors of intellectual disability, and the optimal cutoff for predicting intellectual disability was 17.7 and 9.75 μmol/L for maternal and cord blood Hcy. Conclusion: Perinatal exposure to severe preeclampsia has an adverse effect on postnatal intellectual development, and high maternal and cord blood Hcy may contribute to this association.

Neurodevelopmental assessment of infants born to mothers with hypertensive disorder of pregnancy at six months of age

“…30 A prospective cohort study conducted in China using the Chinese Wechsler Young Children Scale of Intelligence showed that the offspring of mothers with severe PE had 2.86 higher prevalence of intellectual disability than infants born to normotensive mothers. 31 A case-control study of children aged 24-60 months found association between severe PE, autism spectrum disorder and many forms of developmental delay, as confirmed by the Mullen Scales of Early Learning and the Vineland Adaptive Behavior Scales. 32 A systematic review including 45 observational studies reported a significant association of gestational hypertension with lower cognitive function and higher BP in the offspring.…”

Emodin inhibits the progression of acute pancreatitis via regulation of lncRNA TUG1 and exosomal lncRNA TUG1

“…Emodin (1,3,8-Trihydroxy-6-methylanthra-quinone) is a natural product, which originates from Rheum palmatum. Previous studies have reported that emodin exhibits anti-inflammatory effects (8,9). In addition, it has been revealed that emodin can alleviate the symptoms of AP (10).…”