<p>Relation Between Aortic Stiffness Index and Distensibility with Age in Hypertensive Patients</p>

Abstract

Background: Systolic and diastolic blood pressure is associated with physiologic changes of aortic wall and left ventricular structure. We aimed to evaluate aortic stiffness index and distensibility, global longitudinal strain (GLS), post systolic index (PSI) in hypertensive patients and compare these parameters with normotensive subjects. Patients and Methods: Eighty-two patients (42 hypertensive compared with 40 normotensive subjects) with preserved left ventricular ejection fraction and without significant coronary artery disease were enrolled in the study. Systolic and diastolic blood pressure was measured by automated BP measurement system. Aortic stiffness index and distensibility, GLS and PSI were measured by transthoracic echocardiography and compared in both study groups. Results: Aortic stiffness index (0.097 vs 0.069) and E/e´(8.16 vs 6.56) were significantly higher in hypertensive patients, respectively (p<0.05). Aortic distensibility (cm 2 /dyn) (0.28 vs 0.42) and e(cm/s) (8.25 vs 9.52) were significantly lower in hypertensive patients than normotensive subjects (p<0.05). PSI and GLS were not significantly different between both study groups. Aortic stiffness index and distensibility had significant correlation with age in normotensive subjects while this correlation was not statistically significant in hypertensive patients. Conclusion: Hypertension is associated with diastolic dysfunction and abnormal aortic wall compliance. Age-related aortic wall changes can present early in hypertensive patients.

Assessment Parameters for Arrayed Pulse Wave Analysis and Application in Hypertensive Disorders

“…Hypertension is often accompanied by arteriosclerosis [ 30 , 31 ], and the PWV is increased [ 32 ], and vascular compliance is decreased in hypertension [ 33 ]. The increased RP, IP, and mean APV h 3/ h 1 values in the hypertensive group in this study are consistent with the findings of previous reports [ 34 ].…”

Inferring Multi-Organ Genetic Causal Connections using Imaging and Clinical Data through Mendelian Randomization

“…In addition to LV traits, hypertension also affected multiple other CMR traits. For example, it had negative causal impacts on Aao and Dao distensibility 52–54 ( β < −0.10, P < 2.11ξ10 −5 , 7/8 MR methods significant), as well as positive effects on AAo and Dao minimum/maximum areas (AAo max and AAo min areas, β > 0.10, P < 3.32ξ10 −6 , 7/8 MR methods significant). The causal effects were also observed in several LA traits, such as negative effects on the left atrium ejection fraction ( β < −0.07, P < 4.45ξ10 −4 , 7/8 MR methods significant) as well as positive effects on left atrium minimum/maximum volumes (LA min and LA max volumes, β > 0.06, P < 4.72ξ10 −4 , 6/8 MR methods significant).…”

Soft-Tissue Material Properties and Mechanogenetics during Cardiovascular Development

“…As such, pulmonary congestion occurs when the longitudinal strain is higher than circumferential strain. Reduced strains in LV [16] and systolic strains [15], as well as increased stiffness [16], cause a hypertensive heart. Hypertrophy occurs when there is an increased ventricular wall thickness and stiffness [17].…”

“…Mechanical characterization is critical to detect cardiac anomalies with clinical significance at the early stages. An abnormality such as increased or decreased stresses, strains, or other mechanical factors can cause a fluctuation in the upstream transcription factors, which are indicative of the prevalence of cardiac defects [14][15][16][17][18][19]. Well-established transcription factors, such as KLF-2, ET1, and NOS3, are activated by wall shear stress [20][21][22].…”