&lt;p&gt;Rifampicin-Carbohydrate Spray-Dried Nanocomposite: A Futuristic Multiparticulate Platform For Pulmonary Delivery&lt;/p&gt;

Mehanna, Mohammed M.; Mohyeldin, Salma M.; Elgindy, Nazik A.

doi:10.2147/ijn.s211182

Cited by 38 publications

(17 citation statements)

References 71 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the case of the lamella-covered spheres, we suppose that crystallization started in the outer regions, and the block-like crystallites started to peel off the spheres, resulting in these “bushy”/”pineal” spheres ( Figure 6 /α). This morphology shows a resemblance to spray-dried particles [ 33 , 34 , 35 ], but the PLA-generated particles were smaller, and no additive was needed.…”

Section: Discussionmentioning

confidence: 88%

Fabrication of Submicrometer-Sized Meloxicam Particles Using Femtosecond Laser Ablation in Gas and Liquid Environments

et al. 2021

View full text Add to dashboard Cite

In pharmaceutical development, more and more drugs are classified as poorly water-soluble or insoluble. Particle size reduction is a common way to fight this trend by improving dissolution rate, transport characteristics and bioavailability. Pulsed laser ablation is a ground-breaking technique of drug particle generation in the nano- and micrometer size range. Meloxicam, a commonly used nonsteroidal anti-inflammatory drug with poor water solubility, was chosen as the model drug. The pastille pressed meloxicam targets were irradiated by a Ti:sapphire laser (τ = 135 fs, λc = 800 nm) in air and in distilled water. Fourier transform infrared and Raman spectroscopies were used for chemical characterization and scanning electron microscopy to determine morphology and size. Additional particle size studies were performed using a scanning mobility particle sizer. Our experiments demonstrated that significant particle size reduction can be achieved with laser ablation both in air and in distilled water without any chemical change of meloxicam. The size of the ablated particles (~50 nm to a few microns) is approximately at least one-tenth of the size (~10–50 micron) of commercially available meloxicam crystals. Furthermore, nanoaggregate formation was described during pulsed laser ablation in air, which was scarcely studied for drug/organic molecules before.

show abstract

Section: Discussionmentioning

confidence: 88%

Fabrication of Submicrometer-Sized Meloxicam Particles Using Femtosecond Laser Ablation in Gas and Liquid Environments

et al. 2021

View full text Add to dashboard Cite

show abstract

“…All formulations were investigated in triplicate. Furthermore, Carr index and the Hausner ratio were determined with the equations below [47] :

…”

Section: Methodsmentioning

confidence: 99%

The effect of ethanol on the habit and in vitro aerodynamic results of dry powder inhalation formulations containing ciprofloxacin hydrochloride

Benke

Winter

Szabó‐Révész

et al. 2021

Asian Journal of Pharmaceutical Sciences

View full text Add to dashboard Cite

Graphical abstract Dry powder inhalation (DPI) formulations containing ciprofloxacin hydrochloride (CIP) as a model drug were prepared by spray-drying in the presence of different ethanol concentrations. The role of ethanol on the habit and aerodynamics of the DPI samples was examined in detail. The roughness, depth and width of the dimples were uniquely expressed. A new correlation was determined between the mass median aerodynamic diameter (MMAD)/D (0.5) ratio and cohesion work (Wc). DPI formulation containing 30% ethanol in the stock solution had the best in vitro aerodynamic results.

show abstract

“…The NCMP powder yield was calculated as the percentage mass of the predictable total powder yield as follows: 30 Yield %…”

Section: Spray-dried Cip-nlc Characterization Dry Powder Yieldmentioning

confidence: 99%

Development of Inhalable Nanostructured Lipid Carriers for Ciprofloxacin for Noncystic Fibrosis Bronchiectasis Treatment

Almurshedi¹,

Aljunaidel²,

AlQuadeib³

et al. 2021

IJN

View full text Add to dashboard Cite

Ciprofloxacin (CIP) has poor lung targeting after oral inhalation. This study developed optimized inhalable nanostructured lipid carriers (NLCs) for CIP to enhance deposition and accumulation in deeper parts of the lungs for treatment of noncystic fibrosis bronchiectasis (NCFB). Methods: NLC formulations based on stearic acid and oleic acid were successfully prepared by hot homogenization and in vitro-characterized. CIP-NLCs were formulated into nanocomposite micro particles (NCMPs) for administration in dry powder inhalation (DPI) formulations by spray-drying (SD) using different ratios of chitosan (CH) as a carrier. DPI formulations were evaluated for drug content and in vitro deposition, and their mass median aerodynamic diameter (MMAD), fine particle fraction (FPF), fine particle dose (FPD), and emitted dose (ED) were determined. Results: The CIP-NLCs were in the nanometric size range (102.3 ± 4.6 nm), had a low polydispersity index (0.267 ± 0.12), and efficient CIP encapsulation (98.75% ± 0.048%), in addition to a spherical and smooth shape with superior antibacterial activity. The in vitro drug release profile of CIP from CIP-NLCs showed 80% release in 10 h. SD of CIP-NLCs with different ratios of CH generated NCMPs with good yield (>65%). The NCMPs had a corrugated surface, but with increasing lipid:CH ratios, more spherical, smooth, and homogenous NCMPs were obtained. In addition, there was a significant change in the FPF with increasing lipid:CH ratios (P ˂ 0.05). NCMP-1 (lipid:CH = 1:0.5) had the highest FPD (45.0 µg) and FPF (49.2%), while NCMP-3 (lipid:CH = 1:1.5) had the lowest FPF (37.4%). All NCMP powders had an MMAD in the optimum size range of 3.9-5.1 μm. Conclusion: Novel inhalable CIP NCMP powders are a potential new approach to improved target ability and delivery of CIP for NCFB treatment.

show abstract

<p>Rifampicin-Carbohydrate Spray-Dried Nanocomposite: A Futuristic Multiparticulate Platform For Pulmonary Delivery</p>

Cited by 38 publications

References 71 publications

Fabrication of Submicrometer-Sized Meloxicam Particles Using Femtosecond Laser Ablation in Gas and Liquid Environments

Fabrication of Submicrometer-Sized Meloxicam Particles Using Femtosecond Laser Ablation in Gas and Liquid Environments

The effect of ethanol on the habit and in vitro aerodynamic results of dry powder inhalation formulations containing ciprofloxacin hydrochloride

Development of Inhalable Nanostructured Lipid Carriers for Ciprofloxacin for Noncystic Fibrosis Bronchiectasis Treatment

Contact Info

Product

Resources

About