&lt;p&gt;Rifampicin-Resistant &lt;em&gt;Mycobacterium tuberculosis&lt;/em&gt; Among Patients with Presumptive Tuberculosis in Addis Ababa, Ethiopia&lt;/p&gt;

Araya, Shambel; Negesso, Abebe Edao; Tamir, Zemenu

doi:10.2147/idr.s263023

Cited by 22 publications

(28 citation statements)

References 40 publications

(65 reference statements)

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“…The prevalence of M. tuberculosis among previously treated patients was higher 24.1% than treatment new patients 13.4%, with statistical signi cant difference (P < 0.050). Our nding agrees with studies done at Nepal (27), Hiwot Fana (10) and St. Peter Tuberculosis Specialized Hospital (24). High prevalence of rifampicin resistant M. tuberculosis was also detected among patients who had a history of previously taking anti-tuberculosis drugs (15.4 %) which is comparable with studies from Eastern Uttar Pradesh (12), Nepal 13.79% (27) and Addis Ababa 27.4% (9).This might be due to lack of success from previous tuberculosis treatment history and patients with previously history of taking anti-tuberculosis drugs were more likely to harbor drug-resistant bacilli because of previous exposure of bacilli to TB agents.…”

Section: Associated Factors Of Tuberculosis Infections Among Tb Presumptivesupporting

confidence: 92%

“…The prevalence of M. tuberculosis was 17% in males and 13.2% in females but no statistically signi cant association was observed. This study is in agreement with WHO 2020 report (23), India (12), Nigeria (21), St. Peter Tuberculosis Specialized Hospital (24), and Felege Hiwot and Debre Tabor (11). This Variation could be due to difference in community cultural expectations on attempt to get healthcare services, having habit of smoking and alcoholism, high level exposure of males to surrounding.…”

Section: Associated Factors Of Tuberculosis Infections Among Tb Presumptivesupporting

confidence: 91%

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Rifampicin-resistance Pattern of Mycobacterium Tuberculosis and Associated Risk Factors Among Presumptive Pulmonary and Extra Pulmonary Tuberculosis Patients at Madda Walabu University Goba Referral Hospital, Southeast Ethiopia

Wt¹,

Sg²,

Mm³

2021

Preprint

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Background: Drug resistant M.tuberculosis is one of the serious public health trouble that intimidating progress made in tuberculosis cases and control in several countries. Early detection of drug-resistant tuberculosis is crucial for patient management and infection control. Methods: Hospital based cross-sectional study design was conducted from October 2020 to February 2021. Detection of Mycobacterium tuberculosis and resistance to Rifampicin pattern was determined by using GeneXpert MTB/RIF assay. Data were entered and analyzed by SPSS version 23.0. Bivariate and multivariate analyses were used to examine the relationship between dependent and independent variables. Less than 0.05 P-value was used to show significance.Results: A total of 301 presumptive tuberculosis patients were included in the study; of these, 46 (15.3%) of them were identified as having Mycobacterium tuberculosis, 2/46 (4.35%) were resistant to Rifampicin and 4/46 (14.8%) patients were TB/HIV co-infected. From the total of M. tuberculosis detected 40 (16.7%) were identified in pulmonary and 6 (9.8%) were in extra-pulmonary presumptive patients. Rifampicin-resistant M. tuberculosis was detected in 2 patients who had a history of taking Anti-tuberculosis drugs. Conclusion: Previous history of tuberculosis treatment and having close contact history with tuberculosis patients were found as important associated factors that enhance the prevalence of tuberculosis among presumptive tuberculosis patients. This indicates the mandate to make better and oversee the treatment protocol to control the burden of drug resistant M.tuberculosis.

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Section: Associated Factors Of Tuberculosis Infections Among Tb Presumptivesupporting

confidence: 92%

Section: Associated Factors Of Tuberculosis Infections Among Tb Presumptivesupporting

confidence: 91%

Rifampicin-resistance Pattern of Mycobacterium Tuberculosis and Associated Risk Factors Among Presumptive Pulmonary and Extra Pulmonary Tuberculosis Patients at Madda Walabu University Goba Referral Hospital, Southeast Ethiopia

Wt¹,

Sg²,

Mm³

2021

Preprint

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“…This result is in agreement with previous studies conducted in Ethiopia. 15 , 23 , 40 Enhanced frequency of MTB in patients having a history of previous treatment indicates high transmission of TB infection in the community. So, serious emphasis should be given for the prevention and control to limit its transmission.…”

Section: Discussionmentioning

confidence: 99%

The Magnitude of MTB and Rifampicin Resistance MTB Using Xpert-MTB/RIF Assay Among Tuberculosis Suspected Patients in Gedeo Zone, Southern Ethiopia

Diriba¹,

Awulachew²,

Churiso³

2021

IDR

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Background Tuberculosis (TB) remains a major global health problem causing death among millions of people each year. The new barrier that challenges the control of tuberculosis is the emerging and the increasing number of drug-resistant TB that becomes a world concern. This study aimed to determine the magnitude of rifampicin-resistant Mycobacterium tuberculosis (RR-MTB) among presumptive TB patients attending Dilla University Referral Hospital, Gedeo Zone, Ethiopia. Methods A retrospective cross-sectional study was conducted at Dilla University Referral Hospital from January 2014 to December 2020. Sputum results were done using Xpert MTB/RIF assay and other necessary data were collected from the registration logbooks using a standardized data extraction format and analyzed using SPSS version 23 statistical software. Results A total of 17,745 presumptive TB patients were included, of which 62.2% were males. The overall prevalence of Mycobacterium tuberculosis (MTB) was 11.8%, of which 5.1% were confirmed to have RR-MTB. Extra-pulmonary TB was reported in 1.5% of the study participants. The highest prevalence of MTB and RR-MTB was recorded in 2017 with a prevalence of 20.1% and 8.5%, respectively. All age groups were significantly associated with a higher prevalence of MTB ( p < 0.036). TB patients with a history of previous treatment and HIV positive were significantly associated with MTB ( P < 0.021), while RR-MTB was only significantly associated with patients with a history of previous treatment ( P < 0.018). Conclusion A high magnitude of MTB and RR-MTB was reported among TB patients with HIV and a history of previous treatment. Therefore, coordinated efforts should be applied to the improvement of treatment adherence of known TB cases, and appropriate control and prevention methods to reduce the emergence and increase of MTB and RR-MTB cases.

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“…Other study conducted in Addis Ababa also showed that M. tuberculosis was detected in 1714 participants (13.5%) among a total of 12,685 presumptive tuberculosis patients. Of these MTB cases, 169 cases (9.8%) were confirmed to have rifampicin resistant tuberculosis [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Prevalence of active tuberculosis and associated factors among people with chronic psychotic disorders at St. Amanuel Mental Specialized Hospital and Gergesenon Mental Rehabilitation center, Addis Ababa, Ethiopia

Temesgen¹,

Belete

Haile³

et al. 2021

BMC Infect Dis

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Background Tuberculosis (TB) is an airborne chronic infectious disease mainly caused by Mycobacterium tuberculosis complex bacteria. Currently, about 1.7 billion (26%) of the world’s population are considered to be infected with M. tuberculosis. The risk of acquiring tuberculosis is higher on some segments of societies including people with severe mental illness. As a result, World health organization (WHO) strongly recommends screening for tuberculosis in such risk groups and setting. Methods A cross-sectional study was conducted to assess the prevalence of active tuberculosis and associated factors among patients with chronic psychotic disorders admitted at St. Amanuel Mental Specialized Hospital and Gergesenon Mental rehabilitation center from February to June, 2020. All admitted patients were screened for any sign of TB as recommended by WHO. Presumptive TB cases were identified. Sputum samples were collected and tested by Xpert MTB/RIF assay. Data analysis was performed using SPSS version 25.0 statistical software and Chi square analysis was used to test the statistical association. Results From a total 3600 pschotic patients screened for TB, 250 (6.94%) presumptive tuberculosis cases were detected. From these, 27 (10.8%) were positive by Xpert MTB/RIF assay. Most of the patients were males (68.4%). The mean ± SD age of the participant was 36.5 ± 9.7 years. The overall prevalence of tuberculosis was found to be 750 per 100,000 population. The number of patients per room (p = 0.039) was associated with Xpert MTB/RIF positive active tuberculosis. Conclusion The prevalence of active tuberculosis among chronic psychotic patients was high. Number of admitted patients per room was identified as risk factors for Xpert MTB/RIF positive active tuberculosis. Therefore, to control TB transmission in chronic mental health treatment facilities, efforts should be directed to periodic screening for early case detection and improving the number of patients per room.

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<p>Rifampicin-Resistant <em>Mycobacterium tuberculosis</em> Among Patients with Presumptive Tuberculosis in Addis Ababa, Ethiopia</p>

Cited by 22 publications

References 40 publications

Rifampicin-resistance Pattern of Mycobacterium Tuberculosis and Associated Risk Factors Among Presumptive Pulmonary and Extra Pulmonary Tuberculosis Patients at Madda Walabu University Goba Referral Hospital, Southeast Ethiopia

Rifampicin-resistance Pattern of Mycobacterium Tuberculosis and Associated Risk Factors Among Presumptive Pulmonary and Extra Pulmonary Tuberculosis Patients at Madda Walabu University Goba Referral Hospital, Southeast Ethiopia

The Magnitude of MTB and Rifampicin Resistance MTB Using Xpert-MTB/RIF Assay Among Tuberculosis Suspected Patients in Gedeo Zone, Southern Ethiopia

Prevalence of active tuberculosis and associated factors among people with chronic psychotic disorders at St. Amanuel Mental Specialized Hospital and Gergesenon Mental Rehabilitation center, Addis Ababa, Ethiopia

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