&lt;p&gt;Risk Assessment of Recurrence and Autoimmune Disorders in Kikuchi Disease&lt;/p&gt;

Jung, Hyun Joo; Lee, Il Jae; Sh, Yoon

doi:10.2147/rmhp.s271283

Cited by 11 publications

(15 citation statements)

References 23 publications

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“…In a risk assessment study on KFD recurrence, patients with recurrent KFD had significantly more extranodal symptoms, higher prevalence of lymphopenia, and longer durations of lymphocyte count recovery. 28 Another study revealed that extranodal involvement and a long duration of symptoms were significant predictors of KFD recurrence. ANA positivity was more prevalent in the recurrent KFD group in that study, which is also consistent with our observations.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Clinical Characteristics and Risk Factors for Recurrence of Kikuchi–Fujimoto Disease Between Children and Adult

Baek¹,

Kang²,

Lee³

et al. 2022

JIR

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Purpose Kikuchi–Fujimoto disease (KFD) is a rare, benign, and self-limited disease, characterized by cervical lymphadenopathy and fever. Herein, we analyzed the differences in its clinical manifestations and risk factors for recurrence between children and adults. Patients and Methods We retrospectively reviewed the medical records of patients diagnosed with KFD at a tertiary referral hospital between 2005 and 2019. Patients were divided into two groups based on their age: children (<19 years) and adults (≥19 years). Results During the 14-year study period, 127 patients were diagnosed with KFD. Among these, 34 (26.8%) were children and 93 (73.2%) were adults. The fever duration was longer and the frequency of myalgia was higher in adults than in children; however, no other significant symptomatic differences were noted between the two groups. Lymph node evaluation was mainly performed using ultrasound in children (61.8%) and computed tomography in adults (78.5%). Moreover, the frequency of antibiotic use was higher in children than in adults (76.5% vs 54.8%, P = 0.027). In adults, multivariable logistic regression analysis revealed anti-nuclear antibody (ANA) positivity (titer ≥1:80) as a risk factor for recurrence (odds ratio: 7.813; 95% confidence interval = 1.818–33.333; P = 0.006). Conclusion The clinical features of KFD in children and adults were similar; however, the preferred imaging study and frequency of antibiotic use differed significantly between the two groups. Furthermore, in adults, ANA positivity was associated with KFD recurrence. Thus, patients with KFD who present with ANA positivity at diagnosis will benefit from a regular follow-up for monitoring KFD recurrence.

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Section: Discussionmentioning

confidence: 99%

Comparison of Clinical Characteristics and Risk Factors for Recurrence of Kikuchi–Fujimoto Disease Between Children and Adult

Baek¹,

Kang²,

Lee³

et al. 2022

JIR

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“…9 Patients with KD showing progression to autoimmune diseases were more likely to have fever, common extranodal symptoms, a higher recurrence rate, and a higher ANA positivity rate at KD diagnosis. 3 Hepatosplenomegaly was present in 18% of patients of KD 9 with few cases having clinically diagnosed AIH. Our case had biopsy proven AIH without clinical and laboratory findings of SLE.…”

Section: Discussionmentioning

confidence: 99%

“…The extranodal symptoms of KD are uncommon and diverse including skin rash, night sweats, weight loss, headache, cough, and abdominal pain. 3 The disease resolves spontaneously in weeks to months, but in some cases, it may have systemic involvement or evolve to SLE. 1 , 2 , 4 , 5 , 6 A definite diagnosis of KD is based on characteristic pathologic findings on biopsy that differentiate this disease from others such as lymphoma, and infectious lymphadenopathy.…”

Section: Discussionmentioning

confidence: 99%

Case of recurring Kikuchi disease and autoimmune hepatitis

Dhamrah

Ireifej

Ummar

et al. 2022

Clinical Case Reports

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We present a case of a 47‐year‐old female patient with a history of diagnosed Kikuchi disease and autoimmune hepatitis 13 years ago who presented with recurrent fevers and a desquamative rash on the lower extremities. Computed tomography neck showed enlarged lymph nodes, and with her daily fevers and skin rashes the presentation was concerning for recurrence of her Kikuchi disease. The patient was also found to have an elevated anti‐smooth muscle antibody titer, and subsequent liver biopsy confirmed the diagnosis of autoimmune hepatitis. She was started on methylprednisolone with improvement. Our case emphasizes the association of Kikuchi disease with autoimmune conditions other than systemic lupus erythematosus. Given the recurrence of the disease after a decade of quiescence, long‐term follow‐up of patients with Kikuchi disease should be implemented.

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“…Anti-DFS 70 autoantibodies were reported to be more prevalent in healthy individuals than those with autoimmune diseases such as systemic lupus erythematosus (SLE). In a long-term analysis of KFD patients, Hyun et al found that patients who developed autoimmune diseases after KFD were more likely to have extranodal symptoms, KFD recurrence, and anti-nuclear antibody positivity [27]. There is no current literature illustrating how best to follow KFD patients regarding long-term complications and disease associations such as SLE.…”

Section: Discussionmentioning

confidence: 99%

Self-limiting COVID‐19-associated Kikuchi‐Fujimoto disease with heart involvement: case-based review

et al. 2022

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Background The association between COVID-19 infection and the development of autoimmune diseases is currently unknown, but there are already reports presenting induction of different autoantibodies by SARS-CoV-2 infection. Kikuchi-Fuimoto disease (KFD) as a form of histiocytic necrotizing lymphadenitis of unknown origin. Objective Here we present a rare case of KFD with heart involvement after COVID-19 infection. To our best knowledge only a few cases of COVID-19-associated KFD were published so far. Based on presented case, we summarize the clinical course of KFD and its association with autoimmune diseases, as well we discuss the potential causes of perimyocarditis in this case. Methods We reviewed the literature regarding cases of “Kikuchi-Fujimoto disease (KFD)” and “COVID-19” and then “KFD” and “heart” or “myocarditis” by searching medical journal databases written in English in PubMed and Google Scholar. Results Only two cases of KFD after COVID infection have been described so far. Conclusion SARS-CoV-2 infection can also be a new, potential causative agent of developing KFD.

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<p>Risk Assessment of Recurrence and Autoimmune Disorders in Kikuchi Disease</p>

Cited by 11 publications

References 23 publications

Comparison of Clinical Characteristics and Risk Factors for Recurrence of Kikuchi–Fujimoto Disease Between Children and Adult

Comparison of Clinical Characteristics and Risk Factors for Recurrence of Kikuchi–Fujimoto Disease Between Children and Adult

Case of recurring Kikuchi disease and autoimmune hepatitis

Self-limiting COVID‐19-associated Kikuchi‐Fujimoto disease with heart involvement: case-based review

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