&lt;p&gt;Role of maternal serum interleukin 17 in preeclampsia: diagnosis and prognosis&lt;/p&gt;

Shahaway, Alia A. El; Elhady, Rasha R. Abd; Abdelrhman, Amr Ahmed; Yahia, Shymaa

doi:10.2147/jir.s206800

Cited by 29 publications

(14 citation statements)

References 12 publications

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“…At the same time, lower than normal levels of transferrin (Chauhan et al, 2004) or the defects in its saturation ( 20 ) are commonly seen in children with ASD diagnosis ( 21 ). Similarly, levels of IL6, TNF-alpha, and IL17 are repeatedly reported as elevated in both PE and ASD [Kara et al, 2019; ( 22 – 27 )].…”

Section: Discussionmentioning

confidence: 99%

Preeclampsia Drives Molecular Networks to Shift Toward Greater Vulnerability to the Development of Autism Spectrum Disorder

Xie

Wang

et al. 2020

Front. Neurol.

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Preeclampsia (PE) confers a significant risk for subsequent diagnosis with autism spectrum disorder (ASD), with the mechanisms underlying this observation being largely unknown. To identify molecular networks affected by both PE and ASD, we conducted a large-scale literature data mining and a gene set enrichment analysis (GSEA), followed by an expression mega-analysis in 13 independently profiled ASD datasets. Sets of genes implicated in ASD and in PE significantly overlap (156 common genes; p = 3.14E −67), with many biological pathways shared (94 pathways; p < 1.00E −21). A set of PE-driven molecular triggers possibly contributing to worsening the risk of subsequent ASD was identified, possibly representing a regulatory shift toward greater vulnerability to the development of ASD. Mega-analysis of expression highlighted RPS4Y1, an inhibitor of STAT3 that is expressed in a sexually dimorphic manner, as a contributor to both PE and ASD, which should be evaluated as a possible contributor to male predominance in ASD. A set of PE-driven molecular triggers may shift the developing brain toward a greater risk of ASD. One of these triggers, chromosome Y encoded gene RPS4Y1, an inhibitor of STAT3 signaling, warrants evaluation as a possible contributor to male predominance in ASD.

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Section: Discussionmentioning

confidence: 99%

Preeclampsia Drives Molecular Networks to Shift Toward Greater Vulnerability to the Development of Autism Spectrum Disorder

Xie

Wang

et al. 2020

Front. Neurol.

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“…The 14-plex consisted of granulocyte-macrophage colony-stimulating factor (GM-CSF), IFN-γ, IL-1β, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12 (p70), IL-13, IL-17A, IL-23, and TNFα. This panel was selected because it contains cytokines that have been identified as part of the cytokine storm in response to severe SARS-CoV-2 infection [9], as well as cytokines that have been related to adverse pregnancy outcomes [26,27,28]. The assay sensitivities of these markers range from 0.11 -3.25 pg/mL.…”

Section: Multiplex Analysis Of Cytokinesmentioning

confidence: 99%

Maternal cytokine response after SARS-CoV-2 infection during pregnancy

Gigase

Molenaar

Missall

et al. 2022

Preprint

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Objective: Dysregulation of the immune system during pregnancy is associated with adverse pregnancy outcomes. Recent studies report cytokine changes during the acute phase of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We examine whether there is a lasting association between SARS-CoV-2 infection during pregnancy and peripheral blood cytokine levels. Study design: We conducted a case-control study at the Mount Sinai health system in NYC including 100 SARS-CoV-2 IgG antibody positive people matched to 100 SARS-CoV-2 IgG antibody negative people on age, race/ethnicity, parity, and insurance status. Blood samples were collected at a median gestational age of 34 weeks. Levels of 14 cytokines were measured. Results: Individual cytokine levels and cytokine cluster Eigenvalues did not differ significantly between groups, indicating no persisting maternal cytokine changes after SARS-CoV-2 infection during pregnancy. Conclusion: Our findings suggest that the acute inflammatory response after SARS-CoV-2 infection may be restored to normal values during pregnancy.

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“…The clinical features of PE re ect widespread systemic in ammation [4]. A series of studies have found that the in ammatory cytokines increase because of trophoblast cells during the rst trimester of pregnancy, indicating that in ammatory cytokines play an important role in the development of PE [5,6,7,8,9,10,11,12,13].…”

Section: Introductionmentioning

confidence: 99%

NLRP3 inflammasome in peripheral blood monocytes as a risk factor for early onset pre-eclampsia

Guo

et al. 2022

Preprint

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Introduction As a leading cause of pregnancy and fetal mortality, pre-eclampsia impacts about 5–8% of pregnancies globally. To date, few studies have focused on the role played by NLRP3 in peripheral blood in early onset PE. In this study, we investigated whether NLRP3 expression in monocytes before 20 weeks of gestation was associated with an increased risk of early onset PE. Methodology During the study period from 2019 to 2021, women with singleton pregnancies were enrolled in this prospective study at the General Hospital of Northern Theater Command. A generalized additive model (GAM) and logistic regression models were applied to determine any association between NLRP3 and the risk of early onset PE. Results In total, 571 and 48 subjects were included in the control and pre-eclampsia groups, respectively. The GAM and logistic regression models showed that NLRP3 was a significant factor for PE occurrence. The area under the curve, accuracy, specificity, sensitivity, positive likelihood ratio, negative likelihood ratio, and diagnostic odds ratio were 0.86, 0.82, 0.95, 0.72, 15.17, 0.29, and 52.0, respectively. Conclusion The monitoring for NLRP3 in peripheral blood may be a potential, prospectively identifying risk factor for preeclampsia.

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<p>Role of maternal serum interleukin 17 in preeclampsia: diagnosis and prognosis</p>

Cited by 29 publications

References 12 publications

Preeclampsia Drives Molecular Networks to Shift Toward Greater Vulnerability to the Development of Autism Spectrum Disorder

Preeclampsia Drives Molecular Networks to Shift Toward Greater Vulnerability to the Development of Autism Spectrum Disorder

Maternal cytokine response after SARS-CoV-2 infection during pregnancy

NLRP3 inflammasome in peripheral blood monocytes as a risk factor for early onset pre-eclampsia

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