&lt;p&gt;Role of radiotherapy in the treatment of metastatic head and neck cancer&lt;/p&gt;

Ordóñez, Rafael; Otero, A.; Jerez, Inmaculada; Medina, J. A.; Lupiáñez-Pérez, Yolanda; Gómez-Millán, Jaime

doi:10.2147/ott.s181697

Cited by 24 publications

(13 citation statements)

References 44 publications

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“…Head and neck cancer (HNC) remain the primary cause of cancer-related mortality in the world. Oral squamous cell carcinoma (OSCC) is the most important type of HNC, accounting for about 90%, characterized by advanced diagnosis (1), poor prognosis (2), low overall survival (3), and high recurrence (4). Head and neck cancer (HNC) are regarded as the tenth most common cancer in the world and the seventh most common cause of cancer deaths.…”

Section: Introductionmentioning

confidence: 99%

Patterns of Immune Infiltration in HNC and Their Clinical Implications: A Gene Expression-Based Study

Song

Deng

et al. 2019

Front. Oncol.

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Background: Immune infiltration of head and neck cancer (HNC) highly correlated with the patient's prognosis. However, previous studies failed to explain the diversity of different cell types that make up the function of the immune response system. The aim of the study was to uncover the differences in immune phenotypes of the tumor microenvironment (TME) between HNC adjacent tumor tissues and tumor tissues using CIBERSORT method and explore their therapeutic implications.Method: In current work, we employed the CIBERSORT method to evaluate the relative proportions of immune cell profiling in 11 paired HNC and adjacent samples, and analyzed the correlation between immune cell infiltration and clinical information. The tumor-infiltrating immune cells of TCGA HNC cohort was analyzed for the first time. The fractions of LM22 immune cells were imputed to determine the correlation between each immune cell subpopulation and survival and response to chemotherapy. Three types of molecular classification were identified via “CancerSubtypes” R-package. The functional enrichment was analyzed in each subtype.Results: The profiles of immune infiltration in TCGA HNC cohort significantly vary between paired cancer and para-cancerous tissue and the variation could reflect the individual difference. Total Macrophage, Macrophages M0 and NK cells resting were elevated in HNC tissues, while total T cells, total B cells, T cells CD8, B cell navie, T cell follicular helper, NK cells activated, Monocyte and Mast cells resting were decreased when compared to paracancerous tissues. Among each cell immune subtype, T cells regulatory Tregs, B cells naïve, T cells follicular helper, and T cells CD4 memory activated was significantly associated with HNC survival. Three clusters were observed via Cancer Subtypes R-package. Each cancer subtype has a specific molecular classification and subtype-specific immune cell characterization.Conclusions: Our data suggest a difference in immune response may be an important driver of HNC progression and response to treatment. The deconvolution algorithm of gene expression microarray data by CIBERSOFT provides useful information about the immune cell composition of HNC patients.

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Section: Introductionmentioning

confidence: 99%

Patterns of Immune Infiltration in HNC and Their Clinical Implications: A Gene Expression-Based Study

Song

Deng

et al. 2019

Front. Oncol.

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“…Radiotherapy as a usual treatment is also used for other skin cancers, such as nonmelanoma skin cancer [50] and malignancies [51,52]. However, almost all of them, acute and chronic side effects, e.g., dermatitis, erythema, ulceration, and fibrosis, will occur.…”

Section: Discussionmentioning

confidence: 99%

Comparison of the Effect of Alpha and Hydrocortisone Ointments on Prevention of Acute Skin Complications Due to Radiotherapy in Breast Cancer Patients

Rezaei

Khoshay

Amirifard

et al. 2021

Journal of Skin Cancer

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Background. Radiotherapy in breast cancer patients is associated with acute and delayed side effects. This study aimed to compare the effect of alpha and hydrocortisone 1% (H1%) ointments on prevention of acute skin complications due to radiotherapy in breast cancer patients. Methods. This clinical trial was conducted on 86 patients with breast cancer in the radiotherapy center of Imam Reza Hospital of Kermanshah, Iran. Using the records, the patients were selected and randomly divided into alpha and H1% groups after obtaining informed consent. The severity of dermatitis, complications, and patient complaints during treatment were evaluated weekly for up to 6 weeks by RTOG criteria. Data were analyzed using SPSS-16 software. Results. At the end of the third, fourth, fifth, and sixth weeks, 10 (11.7%), 25 (29.1%), 53 (61.6%), and 28 (32.6%) patients had skin complications, respectively. In weeks 5 and 6 in the H1 group, the incidence of complications was higher ( P = 0.001). The frequency of pain and burning complaints at the end of the third, fourth, fifth, and sixth weeks was 15 (17.4%), 37 (43.0%), 52 (60.5%), and 1(1.2%), respectively. Pain and burning intensity in the fourth and fifth weeks in the H1 group was lower than alpha ( P = 0010). Complaints of skin itching at the end of the third, fourth, and fifth weeks were 16 (18.6%), 25 (29.1%), and 28 (32.6), respectively. This complication was lower in the H1% group during these weeks ( P < 0.05). Conclusion. Alpha ointment is more effective than H1% in relieving pain and burning, preventing complications except itching. It seems using an alpha ointment or combining it with H1% is an appropriate strategy to reduce the rate of injuries and skin complications of radiotherapy.

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“…A comprehensive review about this setting and the published experience is available in the literature. 41 In this scenario, the choice of the best treatment for liver metastases from HNC should be discussed and shared within multidisciplinary teams.…”

Section: Discussionmentioning

confidence: 99%

Local therapies for liver metastases of rare head and neck cancers: a monoinstitutional case series

Bergamini

Cavalieri

Cascella

et al. 2020

Tumori

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Introduction: Transarterial chemoembolization (TACE) and radiofrequency ablation (RFA) are established procedures for treating hepatocellular cancer and selected malignancies with liver metastasis. The aim of this study is to describe a monoinstitutional case series of local approaches in patients with liver metastases from rare head and neck cancers (HNCs). Methods: This is a retrospective series of adult patients with HNC treated with liver locoregional approaches (TACE or RFA) at our institution from 2007 to 2018. In case of chemoembolization, the preferred chemotherapeutic drug was doxorubicin. Response according to RECIST (Response Evaluation Criteria in Solid Tumors) was assessed with contrast-enhanced computed tomography scans. Results: Thirty-four patients were treated (20 men, median age 58 years) with TACE (27), transarterial embolization (2), or RFA (7). Primary tumours were salivary gland (21), thyroid (6), nasopharyngeal (5), and sinonasal cancers (2). Seventeen patients (50%) had a single metastatic liver nodule; 70% of the remaining 17 patients had at least three liver metastases. The median diameter of the metastatic liver mass undergoing treatment was 39 mm (range 11–100 mm). Median follow-up was 27.6 months. Response rate was 35% (3% complete, 32% partial response). Median progression-free survival and overall survival were 6.9 and 19.6 months, respectively. Treatment-related adverse events occurred in 59% of patients (21% grade ⩾ 3; no grade 5). Discussion: This retrospective case series demonstrates that locoregional radiologic approaches for rare HNCs with liver metastases are feasible. These procedures deserve further prospective studies before being considered safe and active in these malignancies where the availability of effective systemic treatments is lacking.

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<p>Role of radiotherapy in the treatment of metastatic head and neck cancer</p>

Cited by 24 publications

References 44 publications

Patterns of Immune Infiltration in HNC and Their Clinical Implications: A Gene Expression-Based Study

Patterns of Immune Infiltration in HNC and Their Clinical Implications: A Gene Expression-Based Study

Comparison of the Effect of Alpha and Hydrocortisone Ointments on Prevention of Acute Skin Complications Due to Radiotherapy in Breast Cancer Patients

Local therapies for liver metastases of rare head and neck cancers: a monoinstitutional case series

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