<p>Role of the pretreatment neutrophil-to-lymphocyte ratio in the survival of primary parotid cancer patients</p>

Abstract

Background: To analyze the value of the pretreatment neutrophil-to-lymphocyte ratio (NLR) in the survival of patients with parotid cancer. Methods: In total, 249 patients were enrolled. Information including age, sex, pretreatment NLR, and pathologic variables such as, tumor stage, intraparotid node (IPN) metastasis, and follow-up findings was extracted and analyzed. Results: IPN metastasis was noted in 45 (18.1%) patients, and the mean NLR was 2.48, with a range from 1.5 to 6.1. The NLR was significantly associated with tumor stage, disease stage, and disease grade. A total of 73 patients died of the disease, and the 10-year disease-specific survival (DSS) rate was 62%. In patients with an NLR<2.48, the 10-year DSS rate was 68%; in patients with an NLR≥2.48, the 10-year DSS rate was 58%, and the difference was significant (P=0.006). Cox model analysis showed that the NLR was an independent prognostic factor for DSS. Conclusion: The long-term survival of primary parotid cancer patients is relatively favorable, and the pretreatment NLR is significantly associated with prognosis.

Significance of the Neutrophil-to-Lymphocyte Ratio in p16-Negative Squamous Cell Carcinoma of Unknown Primary in Head and Neck

“…The association between the NLR and clinical pathologic variables has been described by previous studies in head and neck cancer (19,20,23). Our previous studies reported that a high NLR was related to advanced disease stage, poor differentiation, and advanced lymph node stage in parotid cancer (19,20).…”

“…A recent meta-analysis concluded that an elevated NLR was predictive of poorer overall survival in patients with HNSCC (15). Our previous research also showed that a high NLR was associated with worse prognosis in locally advanced tongue SCC (20). However, none of the abovementioned studies evaluated the p16-negative SCC of unknown primary; thus, this study was the first to note that compared with patients in the other two subgroups, patients with an NLR > 6.0 had the worst prognosis.…”

Significance of Pretreatment Neutrophil-to-Lymphocyte Ratio in Mucoepidermoid Carcinoma of Pediatrics: A Multicenter Study

“…The NLR was calculated within 2 weeks before the initial treatment by the ratio of the absolute neutrophil count to the absolute lymphocyte count (14)(15)(16)(17)(18)(19)(20)(21). The previous reported cutoff values varied from 1.98 to 5 (14)(15)(16)(17)(18)(19)(20), and the standard cutoff value remains unknown. The cutoff value was defined as the mean value of the NLR in current study.…”

The Value of Inflammatory Parameters in the Differantial Diagnosis of “Benign” and “Malignant” Lesions in Parotid Gland Tumors

“…16 Damar ve ark., Cheng ve ark., Kawakita ve ark., Seng ve ark., ile Kuzucu ve ark.nın yaptıkları çalışmalarda, NLR ve PLR'yu malign lezyonlarda daha yüksek olarak saptanmıştır. 1,15,[17][18][19] Malign parotis tümörlü hastalarda, benign parotis tümörlü hastalara göre yüksek NLR, yüksek nötrofil yüzdesi, düşük lenfosit sayısı ve düşük lenfosit yüzdesi saptanmıştır. NLR ve lenfosit yüzdesi kombinasyonunun düşük ve yüksek gradeli tümörleri ayırt etmede bir belirteç olarak kullanılabileceği tespit edilmiştir.…”

“…Bu sonuçlar, NLR'nin parotis tümörlerinde hastalıksız sağkalım için bağımsız prognostik faktör olduğunu düşündürmektedir. 17 Çalışmamızda da NLR seviyesi benign tümörlerde 1,84, malign tümörlerde 2,68; PLR seviyesi benign tümörlerde 114,26, malign tümörlerde 153,44 olarak tespit edilmiştir. Kesim noktası NLR için 2,13, PLR için 126,75 tespit edilmiştir.…”