<p>Screening for Metabolic Syndrome Using an Integrated Continuous Index Consisting of Waist Circumference and Triglyceride: A Preliminary Cross-sectional Study</p>

Abstract

Background: It has been suggested that hypertriglyceridemic waist (HW) phenotype is strongly associated with metabolic syndrome (MetS); however, there are very limited studies integrating triglyceride (TG) and waist circumference (WC) into a continuous variable to investigate the predictive power of this phenotype. Inspired from the triglyceride glucose index (TyG), we developed an integrated continuous index termed waist-triglyceride index (WTI) which was calculated as Ln [TG (mg/dl) WC (cm)/2]. Objective: We aimed to examine the potential of WTI in screening for MetS by comparing this quantitative index with the qualitative HW phenotype and other frequently used indices. Methods: A cross-sectional study was conducted in a total of 3460 non-diabetic adults who participated in an annual health checkup. MetS was defined by the update National Cholesterol Education Program/Adult Treatment Panel ш criteria for Asian Americans. Receiving operating characteristic (ROC) curve and areas under the curve (AUC) were employed to evaluate the performance of the involved indices in screening for MetS. Statistical differences among the AUC values of the indices were compared. Results: In both genders, the AUC value of WTI, TyG or HW phenotype was markedly larger than that of each anthropometric index alone. In men, there were no statistical differences in the AUC values among WTI, TyG and HW phenotype, whereas in women, the AUC value of WTI was significantly larger than that of HW phenotype [difference between area (DBA): 0.042, 95% CI: 0.0224-0.0617, P < 0.0001] and was nominally and significantly smaller than that of TyG (DBA: 0.00646, 95% CI: 0.000903-0.012, P = 0.0227). Conclusion: Our results suggest that there are discriminatory performance between the WTI and HW phenotype in the detection of MetS in women rather than in men. Appropriate markers for screening MetS in population study should be considered according to the genders.

Association Between Four Anthropometric Indexes and Metabolic Syndrome in US Adults

“…Inspired by the TyG, WTI was first proposed by Liu et al. ( 20 ). Their study showed that WTI and MetS risk in the Chinese population was associated, the AUC of WTI predicting MetS is 0.881 in women and 0.830 in men.…”

“…Recently, inspired by the formula of the TyG index, Liu et al. combined WC with TG to develop a new index called waist-triglyceride index (WTI), which showed a strong ability to distinguish MetS ( 20 ).…”

The hypertriglyceridemic waist phenotype is associated with fatty liver and glycometabolic profiles in overweight and obese adults: a cross-sectional study

“…The concept of the hypertriglyceridemic waist phenotype was first proposed by Lemieux et al based on the evidence that high TG or WC alone were inadequate to identify the metabolic triad 9 . This phenotype has been widely accepted in risk assessment or prediction of high visceral fat 25 , diabetes 26 , hypertension 27 , metabolic syndrome 28 , atherosclerosis 29 , cardiovascular diseases 30 , and renal dysfunction 31 . All these results support that the hypertriglyceridemic waist phenotype is a cost-effective screening tool that can be used in clinical practice and is an efficient and effective phenotype that can be used for health management.…”

The Association Between Hypertriglyceridemic-Waist Phenotype and Chronic Kidney Disease in Patients with Type 2 Diabetes: A Cross-Sectional METAL Study

“…The HTGW phenotype has also been widely accepted in risk assessment or prediction of high visceral fat, 14 metabolic syndrome, 54 and fatty liver. 55 All these results support that the HTGW phenotype is a cost-effective screening tool that can be used in clinical practice and an efficient and effective phenotype that can be used in health management.…”