&lt;p&gt;Sex disparities in the epidemic of type 2 diabetes in Mexico: national and state level results based on the Global Burden of Disease Study, 1990–2017&lt;/p&gt;

Dávila-Cervantes, Claudio Alberto; Agudelo-Botero, Marcela

doi:10.2147/dmso.s205198

Cited by 18 publications

(12 citation statements)

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“…This coincides with the fact that mortality due to T2D in people aged 15 years or older in Mexico has increased by around 50% for men and 10% in women between 1990 and 2017. 32 The data also indicate that Mexican men receive less information regarding this disease than women, in addition to that, in general, people with T2D do not take controls to avoid or delay their complications, such as physical activity or modify the diet. 33 The differences by sex have been under-analysed, and little is known about the role that gender has regarding the progression and outcome of the various chronic diseases, 8 29 31 therefore, it is necessary that future research explores this subject in depth.…”

Section: Discussionmentioning

confidence: 95%

Overview of the burden of chronic kidney disease in Mexico: secondary data analysis based on the Global Burden of Disease Study 2017

et al. 2020

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ObjectiveTo describe the evolution of the burden of chronic kidney disease (CKD) in Mexico by states, sex and subtypes from 1990 to 2017.DesignSecondary data analysis based on the Global Burden of Disease Study (GBD) 2017.ParticipantsMexico and its 32 states. Data were publicly available and de-identified and individuals were not involved.MethodsWe analysed age-standardised mortality rates, years of life lost (YLL) due to premature death, years lived with disability (YLD) and disability-adjusted life years (DALY), as well as the percentage of change of these indicators between 1990 and 2017.ResultsFrom 1990 to 2017, the number of deaths, YLL, YLD and DALY due to CKD increased from 12 395 to 65 033, from 330 717 to 1 544 212, from 86 416 to 210 924 and from 417 133 to 1 755 136, respectively. Age-standardised rates went from 28.7 to 58.1 for deaths (% of change 102.3), from 601.2 to 1296.7 for YLL (% of change 115.7), from 158.3 to 175.4 for YLD (% of change 10.9) and from 759.4 to 1472.2 for DALY (% of change 93.8). The highest burden of CKD was for Puebla and the lowest for Sinaloa. It was also greater for men than women. By subtypes of CKD, diabetes and hypertension were the causes that contributed most to the loss of years of healthy life in the Mexican population.ConclusionsMexico has experienced exponential and unprecedented growth in the burden of CKD with significant differences by states, sex and subtypes. Data from the GBD are key inputs to guide decision-making and focus efforts towards the reduction of inequities in CKD. These results should be considered a valuable resource that can help guide the epidemiological monitoring of this disease and prioritise the most appropriate health interventions.

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Section: Discussionmentioning

confidence: 95%

Overview of the burden of chronic kidney disease in Mexico: secondary data analysis based on the Global Burden of Disease Study 2017

et al. 2020

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“…T2DM is the result of combined effects of genetic background, gender, aging, lifestyle, obesity and other factors [21]. Age and gender differences in risk, onset and progress of T2DM was found in previous studies [22,23]. Strati ed by gender and age, rs3825199, rs11107116 and rs10492321 conferred to the increased T2DM risk among males not females, and among the subjects aged at ≤ 60 years.…”

Section: Discussionmentioning

confidence: 83%

The Effect of SOCS2 Polymorphisms on Type 2 Diabetes Mellitus Susceptibility and Diabetic Complications in the Chinese Han Population

Pan

Tong

Deng

et al. 2020

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Abstract Propose: We explored the effect of SOCS2 polymorphisms on the development of type 2 diabetes mellitus (T2DM) and diabetic complications.Methods: The subjects consisted of 500 T2DM patients and 501 healthy volunteers. Five variants in SOCS2 were genotyped by Agena MassARRAY system. Logistic regression analysis was utilized to calculate the odds ratio (OR) and 95% confidence intervals (95% CI).Results: Rs3825199 (OR = 1.44, p = 0.007), rs11107116 (OR = 1.39, p = 0.014) and rs10492321 (OR = 1.48, p = 0.004) had the increased T2DM risk. Moreover, the contribution of SOCS2 polymorphisms to T2DM risk was associated with age, gender, smoking and drinking and BMI. SOCS2 variants also had the reduced risk for T2DM patients with diabetic nephropathy, diabetic retinopathy and coronary heart disease.Conclusions: This study firstly reported that rs3825199, rs11107116 and rs10492321 in SOCS2 conferred to the increased risk for T2DM occurrence in the Chinese Han population.

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“… 6 , 7 , 26 Age and gender differences in the risk, onset, and progress of T2DM were found in previous studies. 27 , 28 When stratified by gender and age, rs3825199, rs11107116, and rs10492321 were conferred to an increased T2DM risk among males, and among the subjects aged ≤60 years ( Suppl_Table 3 ). Haplotype analysis revealed that GTA and AGT haplotypes had the higher T2DM susceptibility among males ( Table 5 ).…”

Section: Discussionmentioning

confidence: 99%

The Effect of SOCS2 Polymorphisms on Type 2 Diabetes Mellitus Susceptibility and Diabetic Complications in the Chinese Han Population

Pan¹,

Tong²,

Deng³

et al. 2022

PGPM

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Background SOCS2 is downregulated in diabetes, which might be related to diabetes. We explored the effect of SOCS2 polymorphisms on the development of type 2 diabetes mellitus (T2DM) and diabetic complications. Methods The subjects consisted of 500 patients with T2DM and 501 healthy controls. Five variants in SOCS2 were genotyped by Agena MassARRAY system. RT-qPCR profiling was performed to detect the expression of SOCS2 mRNA. Logistic regression analysis was utilized to calculate odds ratio (OR) and 95% confidence intervals (95% CIs). Results Rs3825199 (OR = 1.44, p = 0.007), rs11107116 (OR = 1.39, p = 0.014) and rs10492321 (OR = 1.48, p = 0.004) had an increased T2DM risk of T2DM. Moreover, the contribution of SOCS2 polymorphisms to T2DM risk was associated with age, gender, smoking, drinking, and BMI. SOCS2 variants also had a reduced risk for T2DM patients with diabetic nephropathy, diabetic retinopathy and coronary heart disease. SOCS2 rs10492321 was the best single locus model. SOCS2 mRNA was downregulated in patients with T2DM compared to healthy controls ( p = 0.029). Conclusion This study firstly reported that rs3825199, rs11107116 and rs10492321 in SOCS2 conferred to an increased risk for the occurrence of T2DM in the Chinese Han population. Moreover, SOCS2 mRNA was downregulated in patients with T2DM, suggesting that SOCS2 might have an important role in the occurrence of T2DM.

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<p>Sex disparities in the epidemic of type 2 diabetes in Mexico: national and state level results based on the Global Burden of Disease Study, 1990–2017</p>

Cited by 18 publications

References 32 publications

Overview of the burden of chronic kidney disease in Mexico: secondary data analysis based on the Global Burden of Disease Study 2017

Overview of the burden of chronic kidney disease in Mexico: secondary data analysis based on the Global Burden of Disease Study 2017

The Effect of SOCS2 Polymorphisms on Type 2 Diabetes Mellitus Susceptibility and Diabetic Complications in the Chinese Han Population

The Effect of SOCS2 Polymorphisms on Type 2 Diabetes Mellitus Susceptibility and Diabetic Complications in the Chinese Han Population

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